2JO1
Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| A | 0005901 | cellular_component | caveola |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006936 | biological_process | muscle contraction |
| A | 0008016 | biological_process | regulation of heart contraction |
| A | 0010734 | biological_process | negative regulation of protein glutathionylation |
| A | 0014704 | cellular_component | intercalated disc |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0017080 | molecular_function | sodium channel regulator activity |
| A | 0030315 | cellular_component | T-tubule |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0043269 | biological_process | regulation of monoatomic ion transport |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0086036 | biological_process | regulation of cardiac muscle cell membrane potential |
| A | 0099106 | molecular_function | ion channel regulator activity |
| A | 1902305 | biological_process | regulation of sodium ion transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1903278 | biological_process | positive regulation of sodium ion export across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01310 |
| Number of Residues | 14 |
| Details | FXYD FXYD family signature. DpFtYDyqSLQigG |
| Chain | Residue | Details |
| A | ASP7-GLY20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-glutathionyl cysteine; alternate","evidences":[{"source":"UniProtKB","id":"P56513","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9Z239","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Z239","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA and PKC","evidences":[{"source":"UniProtKB","id":"P56513","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"21868384","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"UniProtKB","id":"P56513","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21868384","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine; alternate","evidences":[{"source":"PubMed","id":"21868384","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
