Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JLP

Crystal structure of human extracellular copper-zinc superoxide dismutase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005794	cellular_component	Golgi apparatus
A	0005796	cellular_component	Golgi lumen
A	0006801	biological_process	superoxide metabolic process
A	0008201	molecular_function	heparin binding
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0046872	molecular_function	metal ion binding
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
B	0004784	molecular_function	superoxide dismutase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0005796	cellular_component	Golgi lumen
B	0006801	biological_process	superoxide metabolic process
B	0008201	molecular_function	heparin binding
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0046872	molecular_function	metal ion binding
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
C	0004784	molecular_function	superoxide dismutase activity
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005794	cellular_component	Golgi apparatus
C	0005796	cellular_component	Golgi lumen
C	0006801	biological_process	superoxide metabolic process
C	0008201	molecular_function	heparin binding
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0046872	molecular_function	metal ion binding
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
D	0004784	molecular_function	superoxide dismutase activity
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0005796	cellular_component	Golgi lumen
D	0006801	biological_process	superoxide metabolic process
D	0008201	molecular_function	heparin binding
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 225

Chain	Residue
A	HIS96
A	HIS98
A	HIS113
A	HIS163
A	HOH2128

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 226

Chain	Residue
A	HIS113
A	HIS121
A	HIS124
A	ASP127

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 225

Chain	Residue
B	HIS96
B	HIS98
B	HIS113
B	HIS163
B	SCN227

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 226

Chain	Residue
B	HIS113
B	HIS121
B	HIS124
B	ASP127

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SCN B 227

Chain	Residue
B	HIS98
B	PRO112
B	HIS113
B	HIS163
B	ASN180
B	ARG186
B	CU225
B	HOH2195
B	HOH2208
B	HOH2223

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU C 225

Chain	Residue
C	HIS96
C	HIS98
C	HIS113
C	HIS163
C	SCN227

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 226

Chain	Residue
C	HIS113
C	HIS121
C	HIS124
C	ASP127

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SCN C 227

Chain	Residue
C	HIS98
C	PRO112
C	HIS113
C	HIS163
C	ASN180
C	ARG186
C	CU225
C	HOH2193
C	HOH2197
C	HOH2203
C	HOH2214
C	HOH2215

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 225

Chain	Residue
D	HIS96
D	HIS98
D	HIS113
D	HIS163
D	HOH2114

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 226

Chain	Residue
D	HIS113
D	HIS121
D	HIS124
D	ASP127

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. AIHVHQfGDlS

Chain	Residue	Details
A	ALA94-SER104

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGrRlACcvV

Chain	Residue	Details
A	GLY181-VAL192

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Not glycated"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
A	HIS113
A	ARG186

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
B	HIS113
B	ARG186

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
C	HIS113
C	ARG186

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
D	HIS113
D	ARG186

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
A	HIS113

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
B	HIS113

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
C	HIS113

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
D	HIS113

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)