2JLE

Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003824	molecular_function	catalytic activity
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
A	0006310	biological_process	DNA recombination
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0035613	molecular_function	RNA stem-loop binding
A	0042802	molecular_function	identical protein binding
A	0044174	cellular_component	host cell endosome
A	0046872	molecular_function	metal ion binding
A	0055036	cellular_component	virion membrane
A	0072494	cellular_component	host multivesicular body
B	0003676	molecular_function	nucleic acid binding
B	0003824	molecular_function	catalytic activity
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0006310	biological_process	DNA recombination
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0035613	molecular_function	RNA stem-loop binding
B	0042802	molecular_function	identical protein binding
B	0044174	cellular_component	host cell endosome
B	0046872	molecular_function	metal ion binding
B	0055036	cellular_component	virion membrane
B	0072494	cellular_component	host multivesicular body

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE I15 A 1546

Chain	Residue
A	PRO95
A	TYR318
A	LEU100
A	LYS101
A	LYS103
A	TYR181
A	TYR188
A	PHE227
A	TRP229
A	LEU234

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