2JKY
SACCHAROMYCES CEREVISIAE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH GMP (GUANOSINE 5'- MONOPHOSPHATE) (TETRAGONAL CRYSTAL FORM)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0032265 | biological_process | XMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0032265 | biological_process | XMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 5GP A 300 |
| Chain | Residue |
| A | TYR69 |
| A | THR118 |
| A | LYS159 |
| A | LYS187 |
| A | TRP188 |
| A | TYR189 |
| A | TYR191 |
| A | GLU194 |
| A | MG302 |
| A | HOH2029 |
| A | HOH2067 |
| A | LYS85 |
| A | ASP110 |
| A | GLU111 |
| A | VAL112 |
| A | ASP114 |
| A | THR115 |
| A | ARG116 |
| A | THR117 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLY38 |
| A | GLU70 |
| A | ASP71 |
| A | ARG88 |
| A | HOH2068 |
| A | HOH2069 |
| B | ARG48 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | 5GP300 |
| A | HOH2029 |
| A | HOH2038 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 5GP B 300 |
| Chain | Residue |
| B | ASP110 |
| B | GLU111 |
| B | VAL112 |
| B | ASP114 |
| B | THR115 |
| B | ARG116 |
| B | THR117 |
| B | THR118 |
| B | LYS159 |
| B | TRP188 |
| B | TYR189 |
| B | TYR191 |
| B | GLU194 |
| B | HOH2026 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| A | ARG48 |
| B | GLY37 |
| B | GLY38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP114 | |
| B | ASP114 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18245832 |
| Chain | Residue | Details |
| A | LYS85 | |
| A | ASP110 | |
| A | LYS159 | |
| A | TRP188 | |
| B | LYS85 | |
| B | ASP110 | |
| B | LYS159 | |
| B | TRP188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bzy |
| Chain | Residue | Details |
| A | GLU111 | |
| A | ASP114 | |
| A | ASP110 | |
| A | LYS159 | |
| A | LYS163 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bzy |
| Chain | Residue | Details |
| B | GLU111 | |
| B | ASP114 | |
| B | ASP110 | |
| B | LYS159 | |
| B | LYS163 |
