Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JKR

AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
E	0006886	biological_process	intracellular protein transport
E	0015031	biological_process	protein transport
E	0016192	biological_process	vesicle-mediated transport
E	0030117	cellular_component	membrane coat
E	0030276	molecular_function	clathrin binding
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006886	biological_process	intracellular protein transport
I	0008021	cellular_component	synaptic vesicle
I	0009898	cellular_component	cytoplasmic side of plasma membrane
I	0015031	biological_process	protein transport
I	0016020	cellular_component	membrane
I	0016192	biological_process	vesicle-mediated transport
I	0030117	cellular_component	membrane coat
I	0030122	cellular_component	AP-2 adaptor complex
I	0035615	molecular_function	clathrin-cargo adaptor activity
I	0045202	cellular_component	synapse
I	0048488	biological_process	synaptic vesicle endocytosis
I	0072583	biological_process	clathrin-dependent endocytosis
I	0098794	cellular_component	postsynapse
I	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
I	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
I	0098978	cellular_component	glutamatergic synapse
L	0005794	cellular_component	Golgi apparatus
L	0006886	biological_process	intracellular protein transport
L	0016192	biological_process	vesicle-mediated transport
L	0030117	cellular_component	membrane coat
L	0030121	cellular_component	AP-1 adaptor complex
M	0002092	biological_process	positive regulation of receptor internalization
M	0005048	molecular_function	signal sequence binding
M	0005515	molecular_function	protein binding
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005905	cellular_component	clathrin-coated pit
M	0006886	biological_process	intracellular protein transport
M	0006896	biological_process	Golgi to vacuole transport
M	0006900	biological_process	vesicle budding from membrane
M	0008021	cellular_component	synaptic vesicle
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030122	cellular_component	AP-2 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0031623	biological_process	receptor internalization
M	0035615	molecular_function	clathrin-cargo adaptor activity
M	0043195	cellular_component	terminal bouton
M	0044325	molecular_function	transmembrane transporter binding
M	0048488	biological_process	synaptic vesicle endocytosis
M	0050750	molecular_function	low-density lipoprotein particle receptor binding
M	0065003	biological_process	protein-containing complex assembly
M	0072583	biological_process	clathrin-dependent endocytosis
M	0097494	biological_process	regulation of vesicle size
M	0098794	cellular_component	postsynapse
M	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
M	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
M	0098978	cellular_component	glutamatergic synapse
M	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
M	1903077	biological_process	negative regulation of protein localization to plasma membrane
S	0005515	molecular_function	protein binding
S	0005886	cellular_component	plasma membrane
S	0006886	biological_process	intracellular protein transport
S	0008021	cellular_component	synaptic vesicle
S	0009898	cellular_component	cytoplasmic side of plasma membrane
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030122	cellular_component	AP-2 adaptor complex
S	0035615	molecular_function	clathrin-cargo adaptor activity
S	0045202	cellular_component	synapse
S	0048488	biological_process	synaptic vesicle endocytosis
S	0072583	biological_process	clathrin-dependent endocytosis
S	0098794	cellular_component	postsynapse
S	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
S	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
S	0098978	cellular_component	glutamatergic synapse
U	0002092	biological_process	positive regulation of receptor internalization
U	0005048	molecular_function	signal sequence binding
U	0005515	molecular_function	protein binding
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0005905	cellular_component	clathrin-coated pit
U	0006886	biological_process	intracellular protein transport
U	0006896	biological_process	Golgi to vacuole transport
U	0006900	biological_process	vesicle budding from membrane
U	0008021	cellular_component	synaptic vesicle
U	0016020	cellular_component	membrane
U	0016192	biological_process	vesicle-mediated transport
U	0030122	cellular_component	AP-2 adaptor complex
U	0030131	cellular_component	clathrin adaptor complex
U	0031623	biological_process	receptor internalization
U	0035615	molecular_function	clathrin-cargo adaptor activity
U	0043195	cellular_component	terminal bouton
U	0044325	molecular_function	transmembrane transporter binding
U	0048488	biological_process	synaptic vesicle endocytosis
U	0050750	molecular_function	low-density lipoprotein particle receptor binding
U	0065003	biological_process	protein-containing complex assembly
U	0072583	biological_process	clathrin-dependent endocytosis
U	0097494	biological_process	regulation of vesicle size
U	0098794	cellular_component	postsynapse
U	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
U	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
U	0098978	cellular_component	glutamatergic synapse
U	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
U	1903077	biological_process	negative regulation of protein localization to plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 M 1436

Chain	Residue
M	GLN42
M	ARG44
M	ASN217
M	ARG402

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 U 1436

Chain	Residue
U	GLN42
U	ARG44
U	ASN217
U	ARG402

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1624

Chain	Residue
A	HIS531
A	SER565
A	GLN568
A	HIS527

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 1624

Chain	Residue
L	HIS527
L	HIS531
L	VAL562
L	SER565
L	GLN568

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 1583

Chain	Residue
E	ARG304
E	HIS575

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1583

Chain	Residue
B	ARG304
B	HIS575

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 1625

Chain	Residue
L	GLY12
L	GLU36
L	ASN39
L	LYS57
L	TYR58
L	LYS61

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 1626

Chain	Residue
I	ASP75
I	TYR80
L	VAL259
L	LYS260
L	ARG263

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1584

Chain	Residue
B	LYS312
B	ARG313

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1585

Chain	Residue
B	LYS372
B	ARG375

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 1584

Chain	Residue
E	ARG445
U	ARG357

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1625

Chain	Residue
A	ARG11
A	GLY12
A	TYR53
A	LYS57
B	ALA352

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1626

Chain	Residue
A	GLY12
A	GLU36
A	ASN39
A	LYS57
A	TYR58
A	LYS61

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 U 1437

Chain	Residue
E	ARG371
E	LYS372
E	ARG375
U	LYS312
U	SER314

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1586

Chain	Residue
B	ARG371
B	LYS372
B	ARG375
M	LYS312
M	SER314

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 1627

Chain	Residue
E	ASN350
E	ALA352
E	GLN353
L	ARG11
L	TYR53
L	LYS57

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1627

Chain	Residue
A	LYS618
A	LYS619

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 M 1437

Chain	Residue
M	ARG40
M	GLN41
M	GLN42

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 U 1438

Chain	Residue
U	ARG40
U	GLN41
U	GLN42

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 1585

Chain	Residue
E	LYS372
E	ARG375

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1586

Chain	Residue
E	TYR328
U	LYS405
U	HIS416

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 L 1628

Chain	Residue
L	LYS617
L	SO41629

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 1629

Chain	Residue
L	LYS617
L	LYS618
L	GLY622
L	SO41628

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 1630

Chain	Residue
B	GLU471
L	LYS618
L	LYS619

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1628

Chain	Residue
A	LYS617
A	SO41629

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1629

Chain	Residue
A	LYS617
A	LYS618
A	GLY622
A	SO41628

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 U 1439

Chain	Residue
B	SER531
U	THR375
U	ASN376

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 M 1438

Chain	Residue
E	GLN504
M	THR375
M	ASN376

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 1587

Chain	Residue
E	MET74
E	LYS78
E	ARG108
E	CYS112
E	LYS147
U	ARG18
U	TYR20
U	ASP117
U	PHE118

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 1631

Chain	Residue
L	ASP51
L	GLY52
L	ARG87

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1630

Chain	Residue
A	ARG177
A	THR213
A	GLN216

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF

Chain	Residue	Details
I	ILE57-PHE67

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
M	ILE159-GLU179

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
M	ILE263-TYR277

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P18484","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P53680","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12086608","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25061211","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UQI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q96CW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)