2JKC

Crystal Structure of E346D of Tryptophan 7-Halogenase (PrnA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	37
Details	BINDING SITE FOR RESIDUE FAD A 1518

Chain	Residue
A	GLY12
A	VAL47
A	GLY48
A	ALA50
A	ASP185
A	GLU186
A	VAL187
A	CYS217
A	SER218
A	GLY219
A	ARG221
A	GLY13
A	GLY336
A	LEU337
A	PHE341
A	PRO344
A	GLY349
A	ILE350
A	CL1521
A	HOH2006
A	HOH2021
A	HOH2258
A	GLY14
A	HOH2388
A	HOH2389
A	HOH2390
A	HOH2391
A	HOH2392
A	HOH2393
A	HOH2394
A	HOH2395
A	THR15
A	ALA16
A	SER39
A	ILE42
A	ARG44
A	ILE45

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1519

Chain	Residue
A	VAL106
A	GLY458
A	HOH2344
A	HOH2346

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TRP A 1520

Chain	Residue
A	ILE52
A	PRO53
A	HIS101
A	PHE103
A	ASP346
A	TYR443
A	TYR444
A	GLU450
A	PHE454
A	TRP455
A	ASN459
A	HOH2338
A	HOH2396

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL A 1521

Chain	Residue
A	PRO344
A	SER347
A	THR348
A	GLY349
A	FAD1518
A	HOH2254
A	HOH2259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Role in guiding and activating HOCl"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---