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2JJZ

Crystal Structure of Human Iba2, orthorhombic crystal form

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0005509molecular_functioncalcium ion binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0032587cellular_componentruffle membrane
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0051015molecular_functionactin filament binding
A0051017biological_processactin filament bundle assembly
A0070062cellular_componentextracellular exosome
A0097178biological_processruffle assembly
B0003779molecular_functionactin binding
B0005509molecular_functioncalcium ion binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0032587cellular_componentruffle membrane
B0042995cellular_componentcell projection
B0046872molecular_functionmetal ion binding
B0051015molecular_functionactin filament binding
B0051017biological_processactin filament bundle assembly
B0070062cellular_componentextracellular exosome
B0097178biological_processruffle assembly
C0003779molecular_functionactin binding
C0005509molecular_functioncalcium ion binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0032587cellular_componentruffle membrane
C0042995cellular_componentcell projection
C0046872molecular_functionmetal ion binding
C0051015molecular_functionactin filament binding
C0051017biological_processactin filament bundle assembly
C0070062cellular_componentextracellular exosome
C0097178biological_processruffle assembly
D0003779molecular_functionactin binding
D0005509molecular_functioncalcium ion binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0032587cellular_componentruffle membrane
D0042995cellular_componentcell projection
D0046872molecular_functionmetal ion binding
D0051015molecular_functionactin filament binding
D0051017biological_processactin filament bundle assembly
D0070062cellular_componentextracellular exosome
D0097178biological_processruffle assembly
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1126
ChainResidue
AGLU28
AACT1127
BGLU43
BHIS85

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ACT A 1127
ChainResidue
BASN44
BPRO46
BHIS85
BHOH2037
AARG24
AGLU28
AARG31
AZN1126
BGLU43

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN B 1128
ChainResidue
BASP107
BHOH2092
CGLU64

site_idAC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1129
ChainResidue
BGLU54

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 1128
ChainResidue
AHIS85
CGLU28
CACT1129
DGLU43

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT C 1129
ChainResidue
AHIS85
CARG24
CGLU28
CARG31
CZN1128
DGLU43
DASN44
DPRO46

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA C 1130
ChainResidue
CASP41
CASP41

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL C 1131
ChainResidue
CHIS85
CHOH2045
CHOH2046
CHOH2047

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN D 1123
ChainResidue
DGLU32
DGLU32

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
BASP60
DASN62
DGLU64
DGLU66
BASN62
BGLU64
BGLU66
CASP60
CASN62
CGLU64
CGLU66
DASP60

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER2
CSER2
DSER2

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER134
CSER134
DSER134

237735

PDB entries from 2025-06-18

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