Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JJZ

Crystal Structure of Human Iba2, orthorhombic crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0005925	cellular_component	focal adhesion
A	0015629	cellular_component	actin cytoskeleton
A	0032587	cellular_component	ruffle membrane
A	0046872	molecular_function	metal ion binding
A	0051015	molecular_function	actin filament binding
A	0051017	biological_process	actin filament bundle assembly
A	0070062	cellular_component	extracellular exosome
A	0097178	biological_process	ruffle assembly
B	0003779	molecular_function	actin binding
B	0005509	molecular_function	calcium ion binding
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0005925	cellular_component	focal adhesion
B	0015629	cellular_component	actin cytoskeleton
B	0032587	cellular_component	ruffle membrane
B	0046872	molecular_function	metal ion binding
B	0051015	molecular_function	actin filament binding
B	0051017	biological_process	actin filament bundle assembly
B	0070062	cellular_component	extracellular exosome
B	0097178	biological_process	ruffle assembly
C	0003779	molecular_function	actin binding
C	0005509	molecular_function	calcium ion binding
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0005925	cellular_component	focal adhesion
C	0015629	cellular_component	actin cytoskeleton
C	0032587	cellular_component	ruffle membrane
C	0046872	molecular_function	metal ion binding
C	0051015	molecular_function	actin filament binding
C	0051017	biological_process	actin filament bundle assembly
C	0070062	cellular_component	extracellular exosome
C	0097178	biological_process	ruffle assembly
D	0003779	molecular_function	actin binding
D	0005509	molecular_function	calcium ion binding
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0005925	cellular_component	focal adhesion
D	0015629	cellular_component	actin cytoskeleton
D	0032587	cellular_component	ruffle membrane
D	0046872	molecular_function	metal ion binding
D	0051015	molecular_function	actin filament binding
D	0051017	biological_process	actin filament bundle assembly
D	0070062	cellular_component	extracellular exosome
D	0097178	biological_process	ruffle assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1126

Chain	Residue
A	GLU28
A	ACT1127
B	GLU43
B	HIS85

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 1127

Chain	Residue
B	ASN44
B	PRO46
B	HIS85
B	HOH2037
A	ARG24
A	GLU28
A	ARG31
A	ZN1126
B	GLU43

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1128

Chain	Residue
B	ASP107
B	HOH2092
C	GLU64

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1129

Chain	Residue
B	GLU54

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1128

Chain	Residue
A	HIS85
C	GLU28
C	ACT1129
D	GLU43

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT C 1129

Chain	Residue
A	HIS85
C	ARG24
C	GLU28
C	ARG31
C	ZN1128
D	GLU43
D	ASN44
D	PRO46

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 1130

Chain	Residue
C	ASP41
C	ASP41

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1131

Chain	Residue
C	HIS85
C	HOH2045
C	HOH2046
C	HOH2047

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 1123

Chain	Residue
D	GLU32
D	GLU32

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	105
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details