2JJN

Structure of closed cytochrome P450 EryK

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Functional Information from GO Data

ChainGOidnamespacecontents
A0020037molecular_functionheme binding
A0005506molecular_functioniron ion binding
A0004497molecular_functionmonooxygenase activity
A0050661molecular_functionNADP binding
A0016709molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
A0033068biological_processmacrolide biosynthetic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC125BINDING SITE FOR RESIDUE HEM A 412
ChainResidue
AILE87
AHIS88
AHIS95
AARG99
APHE106
ALEU238
AALA241
AGLY242
ATHR245
ATHR246
ALEU249
AMET291
AARG293
ASER345
APHE346
AGLY347
AHIS351
ACYS353
AGLY355
ALEU358
AALA359
AHOH2131
AHOH2537
AHOH2538
AHOH2539

AC26BINDING SITE FOR RESIDUE SO4 A 413
ChainResidue
AARG381
AARG385
ALEU386
AHIS388
AHOH2540
AHOH2541

AC36BINDING SITE FOR RESIDUE SO4 A 414
ChainResidue
AHIS326
AASP327
AARG336
ASER338
AHOH2542
AHOH2543

AC44BINDING SITE FOR RESIDUE SO4 A 415
ChainResidue
AARG55
AHOH2424
AHOH2544
AHOH2545

AC55BINDING SITE FOR RESIDUE SO4 A 416
ChainResidue
AARG99
ASER103
ALEU354
AHOH2546
AHOH2547

AC610BINDING SITE FOR RESIDUE SO4 A 417
ChainResidue
AHIS56
AHIS326
AALA342
ALEU344
AHOH2434
AHOH2464
AHOH2548
AHOH2549
AHOH2550
AHOH2551

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
HEM_2jjn_A_41237PROTOPORPHYRIN IX CONTAINING FE binding site
ChainResidueligand
ALEU63HEM: PROTOPORPHYRIN IX CONTAINING FE
ASER71HEM: PROTOPORPHYRIN IX CONTAINING FE
AILE87-HIS88HEM: PROTOPORPHYRIN IX CONTAINING FE
AHIS95HEM: PROTOPORPHYRIN IX CONTAINING FE
AARG99HEM: PROTOPORPHYRIN IX CONTAINING FE
APHE106HEM: PROTOPORPHYRIN IX CONTAINING FE
AVAL148HEM: PROTOPORPHYRIN IX CONTAINING FE
APHE234HEM: PROTOPORPHYRIN IX CONTAINING FE
AALA237-LEU238HEM: PROTOPORPHYRIN IX CONTAINING FE
AALA241-GLY242HEM: PROTOPORPHYRIN IX CONTAINING FE
ATHR245-THR246HEM: PROTOPORPHYRIN IX CONTAINING FE
ALEU249HEM: PROTOPORPHYRIN IX CONTAINING FE
ALEU282HEM: PROTOPORPHYRIN IX CONTAINING FE
APRO287-PHE288HEM: PROTOPORPHYRIN IX CONTAINING FE
AMET291-ARG293HEM: PROTOPORPHYRIN IX CONTAINING FE
ALEU344-GLY347HEM: PROTOPORPHYRIN IX CONTAINING FE
AVAL350-ALA356HEM: PROTOPORPHYRIN IX CONTAINING FE
ALEU358-ALA359HEM: PROTOPORPHYRIN IX CONTAINING FE
AGLU362-ASN363HEM: PROTOPORPHYRIN IX CONTAINING FE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0008610Cytochrome P450 cysteine heme-iron ligand signature. [FW]-[SGNH]-x-[GD]-{F}-[RKHPT]-{P}-C-[LIVMFAP]-[GAD]
ChainResidueDetails
APHE346-GLY355

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Iron (heme axial ligand) (By similarity)
ChainResidueDetails
ACYS353

CSA12Annotated By Reference To The Literature 1akd
ChainResidueDetails
ATHR245
AILE244

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA12Annotated By Reference To The Literature 1akd
ChainResidueDetails
ATHR245
AILE244