2JJG

Crystal structure of the M. tuberculosis Lysine-epsilon aminotransferase (Rv3290c) complexed to an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009450	biological_process	gamma-aminobutyric acid catabolic process
A	0017000	biological_process	antibiotic biosynthetic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0045484	molecular_function	L-lysine 6-transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP A 600

Chain	Residue
A	GLY128
A	SER329
A	THR330
A	L18601
A	HOH2106
A	HOH2107
A	HOH2108
A	ALA129
A	PHE167
A	HIS168
A	GLU238
A	ASP271
A	VAL273
A	GLN274
A	LYS300

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE L18 A 601

Chain	Residue
A	ALA129
A	PHE167
A	GLY169
A	ARG170
A	LYS181
A	ILE184
A	SER325
A	ASN328
A	SER329
A	THR330
A	PLP600

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Functional Information from PROSITE/UniProt

site_id	PS00600
Number of Residues	38
Details	AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. LIfDEVqt.GCgLtGtawayqqldvap....DIVafGKktqVC

Chain	Residue	Details
A	LEU268-CYS305

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16950391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26003725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CIN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16950391","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16950391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26003725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"16950391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26003725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CIN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d7r

Chain	Residue	Details
A	LYS300
A	PHE167
A	ASP271

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1d7r

Chain	Residue	Details
A	ASP97

---