2JJD
Protein Tyrosine Phosphatase, Receptor Type, E isoform
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| C | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0016311 | biological_process | dephosphorylation |
| D | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| D | 0006470 | biological_process | protein dephosphorylation |
| D | 0016311 | biological_process | dephosphorylation |
| E | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| E | 0006470 | biological_process | protein dephosphorylation |
| E | 0016311 | biological_process | dephosphorylation |
| F | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| F | 0006470 | biological_process | protein dephosphorylation |
| F | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1692 |
| Chain | Residue |
| B | ARG341 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 1693 |
| Chain | Residue |
| D | GLN383 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1692 |
| Chain | Residue |
| A | LEU236 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1693 |
| Chain | Residue |
| B | LEU236 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 1692 |
| Chain | Residue |
| D | LEU236 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 1692 |
| Chain | Residue |
| E | LEU236 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 1692 |
| Chain | Residue |
| F | LEU236 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG |
| Chain | Residue | Details |
| A | VAL333-GLY343 | |
| A | VAL628-GLY638 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS335 | |
| E | CYS630 | |
| F | CYS335 | |
| F | CYS630 | |
| A | CYS630 | |
| B | CYS335 | |
| B | CYS630 | |
| C | CYS335 | |
| C | CYS630 | |
| D | CYS335 | |
| D | CYS630 | |
| E | CYS335 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP303 | |
| D | ASP303 | |
| D | CYS335 | |
| D | GLN379 | |
| E | ASP303 | |
| E | CYS335 | |
| E | GLN379 | |
| F | ASP303 | |
| F | CYS335 | |
| F | GLN379 | |
| A | CYS335 | |
| A | GLN379 | |
| B | ASP303 | |
| B | CYS335 | |
| B | GLN379 | |
| C | ASP303 | |
| C | CYS335 | |
| C | GLN379 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR696 | |
| B | TYR696 | |
| C | TYR696 | |
| D | TYR696 | |
| E | TYR696 | |
| F | TYR696 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | HIS334 | |
| A | THR342 | |
| A | CYS335 | |
| A | GLU238 | |
| A | ASP303 | |
| A | ARG341 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | GLU597 | |
| B | ARG636 | |
| B | CYS630 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| C | CYS335 | |
| C | ASP303 | |
| C | ARG341 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| C | GLU597 | |
| C | ARG636 | |
| C | CYS630 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| D | CYS335 | |
| D | ASP303 | |
| D | ARG341 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| D | GLU597 | |
| D | ARG636 | |
| D | CYS630 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| E | CYS335 | |
| E | ASP303 | |
| E | ARG341 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| E | GLU597 | |
| E | ARG636 | |
| E | CYS630 |
| site_id | CSA17 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| F | CYS335 | |
| F | ASP303 | |
| F | ARG341 |
| site_id | CSA18 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| F | GLU597 | |
| F | ARG636 | |
| F | CYS630 |
| site_id | CSA19 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | THR342 | |
| A | CYS335 | |
| A | ASP303 | |
| A | ARG341 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | HIS334 | |
| B | THR342 | |
| B | CYS335 | |
| B | GLU238 | |
| B | ASP303 | |
| B | ARG341 |
| site_id | CSA20 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | GLU597 | |
| A | THR637 | |
| A | ARG636 | |
| A | CYS630 |
| site_id | CSA21 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | THR342 | |
| B | CYS335 | |
| B | ASP303 | |
| B | ARG341 |
| site_id | CSA22 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | GLU597 | |
| B | THR637 | |
| B | ARG636 | |
| B | CYS630 |
| site_id | CSA23 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| C | THR342 | |
| C | CYS335 | |
| C | ASP303 | |
| C | ARG341 |
| site_id | CSA24 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| C | GLU597 | |
| C | THR637 | |
| C | ARG636 | |
| C | CYS630 |
| site_id | CSA25 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| D | THR342 | |
| D | CYS335 | |
| D | ASP303 | |
| D | ARG341 |
| site_id | CSA26 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| D | GLU597 | |
| D | THR637 | |
| D | ARG636 | |
| D | CYS630 |
| site_id | CSA27 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| E | THR342 | |
| E | CYS335 | |
| E | ASP303 | |
| E | ARG341 |
| site_id | CSA28 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| E | GLU597 | |
| E | THR637 | |
| E | ARG636 | |
| E | CYS630 |
| site_id | CSA29 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| F | THR342 | |
| F | CYS335 | |
| F | ASP303 | |
| F | ARG341 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| C | HIS334 | |
| C | THR342 | |
| C | CYS335 | |
| C | GLU238 | |
| C | ASP303 | |
| C | ARG341 |
| site_id | CSA30 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| F | GLU597 | |
| F | THR637 | |
| F | ARG636 | |
| F | CYS630 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| D | HIS334 | |
| D | THR342 | |
| D | CYS335 | |
| D | GLU238 | |
| D | ASP303 | |
| D | ARG341 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| E | HIS334 | |
| E | THR342 | |
| E | CYS335 | |
| E | GLU238 | |
| E | ASP303 | |
| E | ARG341 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| F | HIS334 | |
| F | THR342 | |
| F | CYS335 | |
| F | GLU238 | |
| F | ASP303 | |
| F | ARG341 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | CYS335 | |
| A | ASP303 | |
| A | ARG341 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | GLU597 | |
| A | ARG636 | |
| A | CYS630 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| B | CYS335 | |
| B | ASP303 | |
| B | ARG341 |
