2JIS
Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004068 | molecular_function | aspartate 1-decarboxylase activity |
| A | 0004782 | molecular_function | sulfinoalanine decarboxylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019449 | biological_process | L-cysteine catabolic process to hypotaurine |
| A | 0019452 | biological_process | L-cysteine catabolic process to taurine |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042412 | biological_process | taurine biosynthetic process |
| B | 0004068 | molecular_function | aspartate 1-decarboxylase activity |
| B | 0004782 | molecular_function | sulfinoalanine decarboxylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019449 | biological_process | L-cysteine catabolic process to hypotaurine |
| B | 0019452 | biological_process | L-cysteine catabolic process to taurine |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042412 | biological_process | taurine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PLP A1494 |
| Chain | Residue |
| A | LEU93 |
| A | TRP276 |
| A | ASN302 |
| A | HIS304 |
| A | LYS305 |
| A | HOH2469 |
| A | HOH2470 |
| A | HOH2471 |
| A | HOH2472 |
| B | CYS356 |
| B | GLY357 |
| A | GLY151 |
| A | GLY152 |
| A | SER153 |
| A | HIS191 |
| A | GLY246 |
| A | THR248 |
| A | ASP273 |
| A | ALA275 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PLP B1494 |
| Chain | Residue |
| A | CYS356 |
| A | GLY357 |
| B | LEU93 |
| B | GLY151 |
| B | GLY152 |
| B | SER153 |
| B | HIS191 |
| B | GLY246 |
| B | THR248 |
| B | ASP273 |
| B | ALA275 |
| B | TRP276 |
| B | ASN302 |
| B | HIS304 |
| B | LYS305 |
| B | HOH2474 |
| B | HOH2475 |
| B | HOH2476 |
| B | HOH2477 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 A1495 |
| Chain | Residue |
| A | TRP415 |
| A | HIS431 |
| A | LEU434 |
| A | SER435 |
| A | ARG461 |
| A | GLY462 |
| A | ASN463 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 B1495 |
| Chain | Residue |
| B | TRP415 |
| B | HIS431 |
| B | LEU434 |
| B | SER435 |
| B | ARG461 |
| B | GLY462 |
| B | ASN463 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ord |
| Chain | Residue | Details |
| A | ASP273 | |
| A | LYS305 | |
| A | HIS191 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ord |
| Chain | Residue | Details |
| B | ASP273 | |
| B | LYS305 | |
| B | HIS191 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ord |
| Chain | Residue | Details |
| A | TYR192 | |
| A | ASP273 | |
| A | LYS305 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ord |
| Chain | Residue | Details |
| B | TYR192 | |
| B | ASP273 | |
| B | LYS305 |
