Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0007596 | biological_process | blood coagulation |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 701 D 1247 |
| Chain | Residue |
| D | HIS57 |
| D | GLY216 |
| D | GLY219 |
| D | CYS220 |
| D | GLY226 |
| D | PHE227 |
| D | TYR228 |
| D | HOH2158 |
| D | HOH2173 |
| D | HOH2174 |
| D | TYR60 |
| D | TRP60 |
| D | ASP189 |
| D | ALA190 |
| D | CYS191 |
| D | GLU192 |
| D | VAL213 |
| D | TRP215 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 1248 |
| Chain | Residue |
| D | LYS169 |
| D | THR172 |
| D | PHE204 |
| D | HOH2123 |
| D | HOH2128 |
| D | HOH2152 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 1249 |
| Chain | Residue |
| D | ARG221 |
| D | LYS224 |
| D | HOH2133 |
| D | HOH2136 |
| D | HOH2143 |
| D | HOH2164 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN H OF HIRUDIN IIIA |
| Chain | Residue |
| D | PHE34 |
| D | GLN38 |
| D | LEU40 |
| D | LEU65 |
| D | ARG67 |
| D | ARG73 |
| D | THR74 |
| D | ARG75 |
| D | ARG75 |
| D | TYR76 |
| D | GLU80 |
| D | LYS81 |
| D | ILE82 |
| D | GLN151 |
| D | HOH2047 |
| D | HOH2050 |
| D | HOH2111 |
| H | HOH2003 |
| H | HOH2004 |
| H | HOH2005 |
| H | HOH2006 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| D | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| D | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
| Chain | Residue | Details |
| H | TYS63 | |
| D | ASP102 | |
| D | SER195 | |
| Chain | Residue | Details |
| D | ASN60 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER195 | |
| D | GLY196 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER195 | |
| D | GLY193 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | GLY193 | |
| D | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | HIS57 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP102 | |
| D | SER195 | |
| D | HIS57 | |
| D | GLY196 | |
