2JGY

The crystal structure of human orotidine-5'-decarboxylase domain of human uridine monophosphate synthetase (UMPS)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV

Chain	Residue	Details
A	ILE309-VAL322

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: For OMPdecase activity => ECO:0000269|PubMed:18184586

Chain	Residue	Details
A	ASP312
A	LYS314
A	ASP317
B	ASP312
B	LYS314
B	ASP317

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD

Chain	Residue	Details
A	SER257
A	ASP317
A	THR321
B	SER257
B	ASP317
B	THR321

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH

Chain	Residue	Details
A	ASP259
A	SER372
A	GLN430
A	GLY450
B	ASP259
B	SER372
B	GLN430
B	GLY450

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL

Chain	Residue	Details
A	LYS281
A	LYS314
B	LYS281
B	LYS314

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS314
A	ASP312

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	LYS314
B	ASP312

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS281
A	ASP317
A	LYS314
A	ASP312

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site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
B	LYS281
B	ASP317
B	LYS314
B	ASP312

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