2JEW

Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A1308

Chain	Residue
A	GLU85
A	ASP159
A	ASP162
A	GLU291
A	HOH2302

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1309

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
A	7201310

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 720 A1310

Chain	Residue
A	HIS69
A	GLU72
A	ASN144
A	ARG145
A	HIS196
A	SER197
A	TYR198
A	SER207
A	ASP255
A	GLU270
A	ZN1309
A	HOH2257
A	HOH2271
A	HOH2303
A	HOH2304

---

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIfMdcGfHArEwISHafcqwF

Chain	Residue	Details
A	PRO60-PHE82

---

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQMIlYPY

Chain	Residue	Details
A	HIS196-TYR206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	GLU270

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	HIS69
A	GLU72
A	HIS196

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00730

Chain	Residue	Details
A	ARG127
A	ASN144
A	SER197
A	TYR248

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG127
A	GLU270

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1cbx

Chain	Residue	Details
A	ARG71
A	GLU270
A	ARG127

---