2JEI

The Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase IV: Steady-state and Pre-steady-state Kinetics and X- Ray Crystallography of Correct and Incorrect Pairing

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0034061	molecular_function	DNA polymerase activity
A	0042276	biological_process	error-prone translesion synthesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A1000

Chain	Residue
A	HOH2085
A	DGT2475
P	DT14
P	HOH2015

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A1001

Chain	Residue
A	ASP7
A	PHE8
A	ASP105
A	CA1002
A	DGT2475

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A1002

Chain	Residue
A	ASP7
A	ASP105
A	GLU106
A	CA1001
A	HOH2088
A	DGT2475
P	DT14

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A1003

Chain	Residue
A	ALA181
A	ILE186
A	HOH2011
A	HOH2054
P	HOH2014

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE DGT A2475

Chain	Residue
A	TYR10
A	PHE11
A	TYR12
A	ALA44
A	THR45
A	TYR48
A	ARG51
A	ASP105
A	LYS159
A	CA1000
A	CA1001
A	CA1002
A	HOH2084
A	HOH2085
A	HOH2086
A	HOH2087
A	HOH2088
P	DT14
T	DC4
T	BZG5

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	Domain: {"description":"UmuC"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Substrate discrimination"}

Chain

Residue

Details

---