2JD2
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with manganese
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050897 | molecular_function | cobalt ion binding |
| A | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050897 | molecular_function | cobalt ion binding |
| B | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A1390 |
| Chain | Residue |
| A | ASP151 |
| A | GLU153 |
| A | GLU222 |
| A | HOH2158 |
| A | HOH2159 |
| A | HOH2160 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A1391 |
| Chain | Residue |
| A | SER213 |
| A | ASN218 |
| A | LYS219 |
| A | HOH2158 |
| A | HOH2161 |
| A | HOH2162 |
| A | ALA176 |
| A | SER177 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1392 |
| Chain | Residue |
| A | ARG162 |
| A | TRP277 |
| A | PRO278 |
| A | HOH2163 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B1390 |
| Chain | Residue |
| B | ASP151 |
| B | GLU153 |
| B | GLU222 |
| B | HOH2221 |
| B | HOH2222 |
| B | HOH2223 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1391 |
| Chain | Residue |
| B | ALA176 |
| B | SER177 |
| B | SER213 |
| B | ASN218 |
| B | LYS219 |
| B | HOH2221 |
| B | HOH2224 |
| B | HOH2225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00183","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
