2JC9

Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000255	biological_process	allantoin metabolic process
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046037	biological_process	GMP metabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A1491

Chain	Residue
A	ASP52
A	ASP54
A	ASP351
A	HOH2410
A	HOH2487
A	HOH2488

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A1492

Chain	Residue
A	TYR457
A	ADN1497
A	HOH2415
A	HOH2456
A	HOH2483
A	HOH2484
A	HOH2485
A	ARG144
A	GLN453
A	ARG456

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A1493

Chain	Residue
A	ASN250
A	HOH2072
A	HOH2211
A	HOH2410
A	HOH2486
A	HOH2487
A	HOH2488
A	HOH2489
A	HOH2490
A	HOH2491

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A1494

Chain	Residue
A	ARG76
A	TRP207

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A1495

Chain	Residue
A	GLY130
A	PRO131
A	ARG134
A	LYS140

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1496

Chain	Residue
A	ASN117
A	LYS344
A	ARG446

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADN A1497

Chain	Residue
A	ARG144
A	ASP145
A	ILE152
A	ASN154
A	PHE354
A	GLN453
A	SO41492
A	HOH2492
A	HOH2493
A	HOH2494

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADN A1498

Chain	Residue
A	PHE127
A	ARG129
A	LYS424
A	HIS428
A	MET432
A	MET436
A	HOH2316
A	HOH2439

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A1489

Chain	Residue
A	PHE283
A	ASP284
A	ILE286
A	GLN322
A	HIS323
A	GLY324
A	ILE325
A	HOH2337
A	HOH2393
A	HOH2482

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A1490

Chain	Residue
A	ASP7
A	LYS61
A	SER62
A	GLU64
A	HOH2004
A	HOH2085

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XCV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21396942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17405878","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2JC9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---