Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JC2

The crystal structure of the natural F112L human sorcin mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0005102	molecular_function	signaling receptor binding
A	0005246	molecular_function	calcium channel regulator activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006816	biological_process	calcium ion transport
A	0007165	biological_process	signal transduction
A	0010459	biological_process	negative regulation of heart rate
A	0010468	biological_process	regulation of gene expression
A	0010649	biological_process	regulation of cell communication by electrical coupling
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0030018	cellular_component	Z disc
A	0030315	cellular_component	T-tubule
A	0031982	cellular_component	vesicle
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0042584	cellular_component	chromaffin granule membrane
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0051924	biological_process	regulation of calcium ion transport
A	0055118	biological_process	negative regulation of cardiac muscle contraction
A	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
A	0070062	cellular_component	extracellular exosome
A	0086004	biological_process	regulation of cardiac muscle cell contraction
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140311	molecular_function	protein sequestering activity
A	0140416	molecular_function	transcription regulator inhibitor activity
A	1901077	biological_process	regulation of relaxation of muscle
A	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	0002020	molecular_function	protease binding
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006816	biological_process	calcium ion transport
B	0007165	biological_process	signal transduction
B	0010459	biological_process	negative regulation of heart rate
B	0010468	biological_process	regulation of gene expression
B	0010649	biological_process	regulation of cell communication by electrical coupling
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0030018	cellular_component	Z disc
B	0030315	cellular_component	T-tubule
B	0031982	cellular_component	vesicle
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0042584	cellular_component	chromaffin granule membrane
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
B	0051924	biological_process	regulation of calcium ion transport
B	0055118	biological_process	negative regulation of cardiac muscle contraction
B	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
B	0070062	cellular_component	extracellular exosome
B	0086004	biological_process	regulation of cardiac muscle cell contraction
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140311	molecular_function	protein sequestering activity
B	0140416	molecular_function	transcription regulator inhibitor activity
B	1901077	biological_process	regulation of relaxation of muscle
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	0002020	molecular_function	protease binding
C	0005102	molecular_function	signaling receptor binding
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006816	biological_process	calcium ion transport
C	0007165	biological_process	signal transduction
C	0010459	biological_process	negative regulation of heart rate
C	0010468	biological_process	regulation of gene expression
C	0010649	biological_process	regulation of cell communication by electrical coupling
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0030018	cellular_component	Z disc
C	0030315	cellular_component	T-tubule
C	0031982	cellular_component	vesicle
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0042584	cellular_component	chromaffin granule membrane
C	0044325	molecular_function	transmembrane transporter binding
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
C	0051924	biological_process	regulation of calcium ion transport
C	0055118	biological_process	negative regulation of cardiac muscle contraction
C	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
C	0070062	cellular_component	extracellular exosome
C	0086004	biological_process	regulation of cardiac muscle cell contraction
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140311	molecular_function	protein sequestering activity
C	0140416	molecular_function	transcription regulator inhibitor activity
C	1901077	biological_process	regulation of relaxation of muscle
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
D	0002020	molecular_function	protease binding
D	0005102	molecular_function	signaling receptor binding
D	0005246	molecular_function	calcium channel regulator activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006816	biological_process	calcium ion transport
D	0007165	biological_process	signal transduction
D	0010459	biological_process	negative regulation of heart rate
D	0010468	biological_process	regulation of gene expression
D	0010649	biological_process	regulation of cell communication by electrical coupling
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0030018	cellular_component	Z disc
D	0030315	cellular_component	T-tubule
D	0031982	cellular_component	vesicle
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0042584	cellular_component	chromaffin granule membrane
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0046982	molecular_function	protein heterodimerization activity
D	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
D	0051924	biological_process	regulation of calcium ion transport
D	0055118	biological_process	negative regulation of cardiac muscle contraction
D	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
D	0070062	cellular_component	extracellular exosome
D	0086004	biological_process	regulation of cardiac muscle cell contraction
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140311	molecular_function	protein sequestering activity
D	0140416	molecular_function	transcription regulator inhibitor activity
D	1901077	biological_process	regulation of relaxation of muscle
D	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1199

Chain	Residue
A	SER172
A	ARG175
A	ARG176

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1200

Chain	Residue
A	GLY66
A	TYR67
A	HOH2023

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C1199

Chain	Residue
C	TYR67
C	ARG116
C	HOH2034
A	PHE156
C	ALA64
C	GLY66

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C1200

Chain	Residue
C	SER172
C	ARG175
C	ARG176

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B1199

Chain	Residue
B	ALA64
B	GLY66

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D1199

Chain	Residue
B	PHE156
D	ALA64
D	GLY66

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRDMSGTMGfnEF

Chain	Residue	Details
A	ASP83-PHE95
A	ASP113-LEU125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)