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2JC2

The crystal structure of the natural F112L human sorcin mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0002020molecular_functionprotease binding
A0005102molecular_functionsignaling receptor binding
A0005246molecular_functioncalcium channel regulator activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006816biological_processcalcium ion transport
A0006880biological_processintracellular sequestering of iron ion
A0006942biological_processregulation of striated muscle contraction
A0007165biological_processsignal transduction
A0007507biological_processheart development
A0007517biological_processmuscle organ development
A0008016biological_processregulation of heart contraction
A0010459biological_processnegative regulation of heart rate
A0010649biological_processregulation of cell communication by electrical coupling
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0030018cellular_componentZ disc
A0030315cellular_componentT-tubule
A0031982cellular_componentvesicle
A0033017cellular_componentsarcoplasmic reticulum membrane
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042584cellular_componentchromaffin granule membrane
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051924biological_processregulation of calcium ion transport
A0055118biological_processnegative regulation of cardiac muscle contraction
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0086004biological_processregulation of cardiac muscle cell contraction
A0140297molecular_functionDNA-binding transcription factor binding
A1901077biological_processregulation of relaxation of muscle
A1901841biological_processregulation of high voltage-gated calcium channel activity
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B0001508biological_processaction potential
B0002020molecular_functionprotease binding
B0005102molecular_functionsignaling receptor binding
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006816biological_processcalcium ion transport
B0006880biological_processintracellular sequestering of iron ion
B0006942biological_processregulation of striated muscle contraction
B0007165biological_processsignal transduction
B0007507biological_processheart development
B0007517biological_processmuscle organ development
B0008016biological_processregulation of heart contraction
B0010459biological_processnegative regulation of heart rate
B0010649biological_processregulation of cell communication by electrical coupling
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0030018cellular_componentZ disc
B0030315cellular_componentT-tubule
B0031982cellular_componentvesicle
B0033017cellular_componentsarcoplasmic reticulum membrane
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042584cellular_componentchromaffin granule membrane
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051924biological_processregulation of calcium ion transport
B0055118biological_processnegative regulation of cardiac muscle contraction
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0070062cellular_componentextracellular exosome
B0086004biological_processregulation of cardiac muscle cell contraction
B0140297molecular_functionDNA-binding transcription factor binding
B1901077biological_processregulation of relaxation of muscle
B1901841biological_processregulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C0001508biological_processaction potential
C0002020molecular_functionprotease binding
C0005102molecular_functionsignaling receptor binding
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006816biological_processcalcium ion transport
C0006880biological_processintracellular sequestering of iron ion
C0006942biological_processregulation of striated muscle contraction
C0007165biological_processsignal transduction
C0007507biological_processheart development
C0007517biological_processmuscle organ development
C0008016biological_processregulation of heart contraction
C0010459biological_processnegative regulation of heart rate
C0010649biological_processregulation of cell communication by electrical coupling
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0030018cellular_componentZ disc
C0030315cellular_componentT-tubule
C0031982cellular_componentvesicle
C0033017cellular_componentsarcoplasmic reticulum membrane
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042584cellular_componentchromaffin granule membrane
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051924biological_processregulation of calcium ion transport
C0055118biological_processnegative regulation of cardiac muscle contraction
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0086004biological_processregulation of cardiac muscle cell contraction
C0140297molecular_functionDNA-binding transcription factor binding
C1901077biological_processregulation of relaxation of muscle
C1901841biological_processregulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D0001508biological_processaction potential
D0002020molecular_functionprotease binding
D0005102molecular_functionsignaling receptor binding
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006816biological_processcalcium ion transport
D0006880biological_processintracellular sequestering of iron ion
D0006942biological_processregulation of striated muscle contraction
D0007165biological_processsignal transduction
D0007507biological_processheart development
D0007517biological_processmuscle organ development
D0008016biological_processregulation of heart contraction
D0010459biological_processnegative regulation of heart rate
D0010649biological_processregulation of cell communication by electrical coupling
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0030018cellular_componentZ disc
D0030315cellular_componentT-tubule
D0031982cellular_componentvesicle
D0033017cellular_componentsarcoplasmic reticulum membrane
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0042584cellular_componentchromaffin granule membrane
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0046982molecular_functionprotein heterodimerization activity
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051924biological_processregulation of calcium ion transport
D0055118biological_processnegative regulation of cardiac muscle contraction
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0070062cellular_componentextracellular exosome
D0086004biological_processregulation of cardiac muscle cell contraction
D0140297molecular_functionDNA-binding transcription factor binding
D1901077biological_processregulation of relaxation of muscle
D1901841biological_processregulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1199
ChainResidue
ASER172
AARG175
AARG176

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1200
ChainResidue
AGLY66
ATYR67
AHOH2023

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C1199
ChainResidue
CTYR67
CARG116
CHOH2034
APHE156
CALA64
CGLY66

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C1200
ChainResidue
CSER172
CARG175
CARG176

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B1199
ChainResidue
BALA64
BGLY66

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D1199
ChainResidue
BPHE156
DALA64
DGLY66

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DRDMSGTMGfnEF
ChainResidueDetails
AASP83-PHE95
AASP113-LEU125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP83
AGLU124
BASP83
BASP85
BSER87
BTHR89
BGLU94
BASP113
BASP115
BSER117
BTHR119
AASP85
BGLU124
CASP83
CASP85
CSER87
CTHR89
CGLU94
CASP113
CASP115
CSER117
CTHR119
ASER87
CGLU124
DASP83
DASP85
DSER87
DTHR89
DGLU94
DASP113
DASP115
DSER117
DTHR119
ATHR89
DGLU124
AGLU94
AASP113
AASP115
ASER117
ATHR119

227111

PDB entries from 2024-11-06

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