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2JC2

The crystal structure of the natural F112L human sorcin mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0005102molecular_functionsignaling receptor binding
A0005246molecular_functioncalcium channel regulator activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006816biological_processcalcium ion transport
A0007165biological_processsignal transduction
A0010459biological_processnegative regulation of heart rate
A0010468biological_processregulation of gene expression
A0010649biological_processregulation of cell communication by electrical coupling
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0030018cellular_componentZ disc
A0030315cellular_componentT-tubule
A0031982cellular_componentvesicle
A0033017cellular_componentsarcoplasmic reticulum membrane
A0042584cellular_componentchromaffin granule membrane
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051924biological_processregulation of calcium ion transport
A0055118biological_processnegative regulation of cardiac muscle contraction
A0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
A0070062cellular_componentextracellular exosome
A0086004biological_processregulation of cardiac muscle cell contraction
A0140297molecular_functionDNA-binding transcription factor binding
A0140311molecular_functionprotein sequestering activity
A0140416molecular_functiontranscription regulator inhibitor activity
A1901077biological_processregulation of relaxation of muscle
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B0002020molecular_functionprotease binding
B0005102molecular_functionsignaling receptor binding
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006816biological_processcalcium ion transport
B0007165biological_processsignal transduction
B0010459biological_processnegative regulation of heart rate
B0010468biological_processregulation of gene expression
B0010649biological_processregulation of cell communication by electrical coupling
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0030018cellular_componentZ disc
B0030315cellular_componentT-tubule
B0031982cellular_componentvesicle
B0033017cellular_componentsarcoplasmic reticulum membrane
B0042584cellular_componentchromaffin granule membrane
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051924biological_processregulation of calcium ion transport
B0055118biological_processnegative regulation of cardiac muscle contraction
B0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
B0070062cellular_componentextracellular exosome
B0086004biological_processregulation of cardiac muscle cell contraction
B0140297molecular_functionDNA-binding transcription factor binding
B0140311molecular_functionprotein sequestering activity
B0140416molecular_functiontranscription regulator inhibitor activity
B1901077biological_processregulation of relaxation of muscle
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C0002020molecular_functionprotease binding
C0005102molecular_functionsignaling receptor binding
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006816biological_processcalcium ion transport
C0007165biological_processsignal transduction
C0010459biological_processnegative regulation of heart rate
C0010468biological_processregulation of gene expression
C0010649biological_processregulation of cell communication by electrical coupling
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0030018cellular_componentZ disc
C0030315cellular_componentT-tubule
C0031982cellular_componentvesicle
C0033017cellular_componentsarcoplasmic reticulum membrane
C0042584cellular_componentchromaffin granule membrane
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051924biological_processregulation of calcium ion transport
C0055118biological_processnegative regulation of cardiac muscle contraction
C0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
C0070062cellular_componentextracellular exosome
C0086004biological_processregulation of cardiac muscle cell contraction
C0140297molecular_functionDNA-binding transcription factor binding
C0140311molecular_functionprotein sequestering activity
C0140416molecular_functiontranscription regulator inhibitor activity
C1901077biological_processregulation of relaxation of muscle
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D0002020molecular_functionprotease binding
D0005102molecular_functionsignaling receptor binding
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006816biological_processcalcium ion transport
D0007165biological_processsignal transduction
D0010459biological_processnegative regulation of heart rate
D0010468biological_processregulation of gene expression
D0010649biological_processregulation of cell communication by electrical coupling
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0030018cellular_componentZ disc
D0030315cellular_componentT-tubule
D0031982cellular_componentvesicle
D0033017cellular_componentsarcoplasmic reticulum membrane
D0042584cellular_componentchromaffin granule membrane
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0046982molecular_functionprotein heterodimerization activity
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051924biological_processregulation of calcium ion transport
D0055118biological_processnegative regulation of cardiac muscle contraction
D0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
D0070062cellular_componentextracellular exosome
D0086004biological_processregulation of cardiac muscle cell contraction
D0140297molecular_functionDNA-binding transcription factor binding
D0140311molecular_functionprotein sequestering activity
D0140416molecular_functiontranscription regulator inhibitor activity
D1901077biological_processregulation of relaxation of muscle
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1199
ChainResidue
ASER172
AARG175
AARG176

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1200
ChainResidue
AGLY66
ATYR67
AHOH2023

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C1199
ChainResidue
CTYR67
CARG116
CHOH2034
APHE156
CALA64
CGLY66

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C1200
ChainResidue
CSER172
CARG175
CARG176

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B1199
ChainResidue
BALA64
BGLY66

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D1199
ChainResidue
BPHE156
DALA64
DGLY66

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DRDMSGTMGfnEF
ChainResidueDetails
AASP83-PHE95
AASP113-LEU125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues140
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues140
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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