2JBM
QPRTASE STRUCTURE FROM HUMAN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0034213 | biological_process | quinolinate catabolic process |
| A | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0034213 | biological_process | quinolinate catabolic process |
| B | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1902494 | cellular_component | catalytic complex |
| C | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0009435 | biological_process | NAD+ biosynthetic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0034213 | biological_process | quinolinate catabolic process |
| C | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1902494 | cellular_component | catalytic complex |
| D | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0009435 | biological_process | NAD+ biosynthetic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0034213 | biological_process | quinolinate catabolic process |
| D | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1902494 | cellular_component | catalytic complex |
| E | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005829 | cellular_component | cytosol |
| E | 0009435 | biological_process | NAD+ biosynthetic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0034213 | biological_process | quinolinate catabolic process |
| E | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 1902494 | cellular_component | catalytic complex |
| F | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005829 | cellular_component | cytosol |
| F | 0009435 | biological_process | NAD+ biosynthetic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0034213 | biological_process | quinolinate catabolic process |
| F | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 1902494 | cellular_component | catalytic complex |
| G | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005829 | cellular_component | cytosol |
| G | 0009435 | biological_process | NAD+ biosynthetic process |
| G | 0016763 | molecular_function | pentosyltransferase activity |
| G | 0034213 | biological_process | quinolinate catabolic process |
| G | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 1902494 | cellular_component | catalytic complex |
| H | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005829 | cellular_component | cytosol |
| H | 0009435 | biological_process | NAD+ biosynthetic process |
| H | 0016763 | molecular_function | pentosyltransferase activity |
| H | 0034213 | biological_process | quinolinate catabolic process |
| H | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 1902494 | cellular_component | catalytic complex |
| I | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005829 | cellular_component | cytosol |
| I | 0009435 | biological_process | NAD+ biosynthetic process |
| I | 0016763 | molecular_function | pentosyltransferase activity |
| I | 0034213 | biological_process | quinolinate catabolic process |
| I | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0070062 | cellular_component | extracellular exosome |
| I | 1902494 | cellular_component | catalytic complex |
| J | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005829 | cellular_component | cytosol |
| J | 0009435 | biological_process | NAD+ biosynthetic process |
| J | 0016763 | molecular_function | pentosyltransferase activity |
| J | 0034213 | biological_process | quinolinate catabolic process |
| J | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0070062 | cellular_component | extracellular exosome |
| J | 1902494 | cellular_component | catalytic complex |
| K | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005829 | cellular_component | cytosol |
| K | 0009435 | biological_process | NAD+ biosynthetic process |
| K | 0016763 | molecular_function | pentosyltransferase activity |
| K | 0034213 | biological_process | quinolinate catabolic process |
| K | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0070062 | cellular_component | extracellular exosome |
| K | 1902494 | cellular_component | catalytic complex |
| L | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005829 | cellular_component | cytosol |
| L | 0009435 | biological_process | NAD+ biosynthetic process |
| L | 0016763 | molecular_function | pentosyltransferase activity |
| L | 0034213 | biological_process | quinolinate catabolic process |
| L | 0034354 | biological_process | 'de novo' NAD+ biosynthetic process from L-tryptophan |
| L | 0042802 | molecular_function | identical protein binding |
| L | 0070062 | cellular_component | extracellular exosome |
| L | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT A 401 |
| Chain | Residue |
| A | THR139 |
| A | ARG140 |
| A | ARG163 |
| A | LYS173 |
| A | HOH2216 |
| A | HOH2374 |
| A | HOH2375 |
| B | ARG104 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT B 401 |
| Chain | Residue |
| B | THR139 |
| B | ARG140 |
| B | ARG163 |
| B | LYS173 |
| B | HOH2321 |
| B | HOH2322 |
| B | HOH2323 |
| A | ARG104 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SRT C 401 |
| Chain | Residue |
| C | THR139 |
| C | ARG140 |
| C | ARG163 |
| C | LYS173 |
| C | HOH2168 |
| C | HOH2280 |
| D | ARG104 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SRT D 401 |
| Chain | Residue |
| C | ARG104 |
| D | THR139 |
| D | ARG140 |
| D | ARG163 |
| D | LYS173 |
| D | HOH2172 |
| D | HOH2290 |
| D | HOH2291 |
| D | HOH2292 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SRT E 401 |
| Chain | Residue |
| E | THR139 |
| E | ARG140 |
| E | ARG163 |
| E | LYS173 |
| E | HOH2155 |
| E | HOH2266 |
| F | ARG104 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT F 401 |
| Chain | Residue |
| E | ARG104 |
| F | THR139 |
| F | ARG140 |
| F | LYS141 |
| F | ARG163 |
| F | LYS173 |
| F | HOH2314 |
| F | HOH2315 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SRT G 401 |
| Chain | Residue |
| G | THR139 |
| G | ARG140 |
| G | ARG163 |
| G | LYS173 |
| G | HOH2106 |
| G | HOH2179 |
| G | HOH2180 |
| G | HOH2181 |
| H | ARG104 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SRT H 401 |
| Chain | Residue |
| G | ARG104 |
| H | THR139 |
| H | ARG140 |
| H | LYS141 |
| H | ARG163 |
| H | LYS173 |
| H | HOH2125 |
| H | HOH2126 |
| H | HOH2127 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT I 401 |
| Chain | Residue |
| I | THR139 |
| I | ARG140 |
| I | LYS141 |
| I | ARG163 |
| I | LYS173 |
| I | HOH2268 |
| I | HOH2269 |
| J | ARG104 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT J 401 |
| Chain | Residue |
| I | ARG104 |
| J | THR139 |
| J | ARG140 |
| J | ARG163 |
| J | LYS173 |
| J | HOH2254 |
| J | HOH2255 |
| J | HOH2256 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SRT K 401 |
| Chain | Residue |
| K | THR139 |
| K | ARG140 |
| K | LYS141 |
| K | ARG163 |
| K | LYS173 |
| K | HOH2124 |
| K | HOH2206 |
| L | ARG104 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SRT L 401 |
| Chain | Residue |
| K | ARG104 |
| L | THR139 |
| L | ARG140 |
| L | ARG163 |
| L | LYS173 |
| L | HOH2148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Region: {"description":"Important for hexamer formation","evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17868694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24038671","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2JBM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26805589","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AYZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| A | ASP224 | |
| A | LYS141 | |
| A | GLU203 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| J | ASP224 | |
| J | LYS141 | |
| J | GLU203 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| K | ASP224 | |
| K | LYS141 | |
| K | GLU203 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| L | ASP224 | |
| L | LYS141 | |
| L | GLU203 |
| site_id | CSA13 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| A | ARG104 |
| site_id | CSA14 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| B | ARG104 |
| site_id | CSA15 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| C | ARG104 |
| site_id | CSA16 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| D | ARG104 |
| site_id | CSA17 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| E | ARG104 |
| site_id | CSA18 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| F | ARG104 |
| site_id | CSA19 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| G | ARG104 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| B | ASP224 | |
| B | LYS141 | |
| B | GLU203 |
| site_id | CSA20 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| H | ARG104 |
| site_id | CSA21 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| I | ARG104 |
| site_id | CSA22 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| J | ARG104 |
| site_id | CSA23 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| K | ARG104 |
| site_id | CSA24 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| L | ARG104 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| C | ASP224 | |
| C | LYS141 | |
| C | GLU203 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| D | ASP224 | |
| D | LYS141 | |
| D | GLU203 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| E | ASP224 | |
| E | LYS141 | |
| E | GLU203 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| F | ASP224 | |
| F | LYS141 | |
| F | GLU203 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| G | ASP224 | |
| G | LYS141 | |
| G | GLU203 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| H | ASP224 | |
| H | LYS141 | |
| H | GLU203 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| I | ASP224 | |
| I | LYS141 | |
| I | GLU203 |
