Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JBM

QPRTASE STRUCTURE FROM HUMAN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009435	biological_process	NAD biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD metabolic process
A	0034213	biological_process	quinolinate catabolic process
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	1902494	cellular_component	catalytic complex
B	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009435	biological_process	NAD biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0019674	biological_process	NAD metabolic process
B	0034213	biological_process	quinolinate catabolic process
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	1902494	cellular_component	catalytic complex
C	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009435	biological_process	NAD biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0019674	biological_process	NAD metabolic process
C	0034213	biological_process	quinolinate catabolic process
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	1902494	cellular_component	catalytic complex
D	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009435	biological_process	NAD biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0019674	biological_process	NAD metabolic process
D	0034213	biological_process	quinolinate catabolic process
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	1902494	cellular_component	catalytic complex
E	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009435	biological_process	NAD biosynthetic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0019674	biological_process	NAD metabolic process
E	0034213	biological_process	quinolinate catabolic process
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
E	1902494	cellular_component	catalytic complex
F	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009435	biological_process	NAD biosynthetic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0019674	biological_process	NAD metabolic process
F	0034213	biological_process	quinolinate catabolic process
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
F	1902494	cellular_component	catalytic complex
G	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009435	biological_process	NAD biosynthetic process
G	0016757	molecular_function	glycosyltransferase activity
G	0016763	molecular_function	pentosyltransferase activity
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0019674	biological_process	NAD metabolic process
G	0034213	biological_process	quinolinate catabolic process
G	0042802	molecular_function	identical protein binding
G	0070062	cellular_component	extracellular exosome
G	1902494	cellular_component	catalytic complex
H	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009435	biological_process	NAD biosynthetic process
H	0016757	molecular_function	glycosyltransferase activity
H	0016763	molecular_function	pentosyltransferase activity
H	0019363	biological_process	pyridine nucleotide biosynthetic process
H	0019674	biological_process	NAD metabolic process
H	0034213	biological_process	quinolinate catabolic process
H	0042802	molecular_function	identical protein binding
H	0070062	cellular_component	extracellular exosome
H	1902494	cellular_component	catalytic complex
I	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009435	biological_process	NAD biosynthetic process
I	0016757	molecular_function	glycosyltransferase activity
I	0016763	molecular_function	pentosyltransferase activity
I	0019363	biological_process	pyridine nucleotide biosynthetic process
I	0019674	biological_process	NAD metabolic process
I	0034213	biological_process	quinolinate catabolic process
I	0042802	molecular_function	identical protein binding
I	0070062	cellular_component	extracellular exosome
I	1902494	cellular_component	catalytic complex
J	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0009435	biological_process	NAD biosynthetic process
J	0016757	molecular_function	glycosyltransferase activity
J	0016763	molecular_function	pentosyltransferase activity
J	0019363	biological_process	pyridine nucleotide biosynthetic process
J	0019674	biological_process	NAD metabolic process
J	0034213	biological_process	quinolinate catabolic process
J	0042802	molecular_function	identical protein binding
J	0070062	cellular_component	extracellular exosome
J	1902494	cellular_component	catalytic complex
K	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009435	biological_process	NAD biosynthetic process
K	0016757	molecular_function	glycosyltransferase activity
K	0016763	molecular_function	pentosyltransferase activity
K	0019363	biological_process	pyridine nucleotide biosynthetic process
K	0019674	biological_process	NAD metabolic process
K	0034213	biological_process	quinolinate catabolic process
K	0042802	molecular_function	identical protein binding
K	0070062	cellular_component	extracellular exosome
K	1902494	cellular_component	catalytic complex
L	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009435	biological_process	NAD biosynthetic process
L	0016757	molecular_function	glycosyltransferase activity
L	0016763	molecular_function	pentosyltransferase activity
L	0019363	biological_process	pyridine nucleotide biosynthetic process
L	0019674	biological_process	NAD metabolic process
L	0034213	biological_process	quinolinate catabolic process
L	0042802	molecular_function	identical protein binding
L	0070062	cellular_component	extracellular exosome
L	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT A 401

Chain	Residue
A	THR139
A	ARG140
A	ARG163
A	LYS173
A	HOH2216
A	HOH2374
A	HOH2375
B	ARG104

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT B 401

Chain	Residue
B	THR139
B	ARG140
B	ARG163
B	LYS173
B	HOH2321
B	HOH2322
B	HOH2323
A	ARG104

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SRT C 401

Chain	Residue
C	THR139
C	ARG140
C	ARG163
C	LYS173
C	HOH2168
C	HOH2280
D	ARG104

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SRT D 401

Chain	Residue
C	ARG104
D	THR139
D	ARG140
D	ARG163
D	LYS173
D	HOH2172
D	HOH2290
D	HOH2291
D	HOH2292

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SRT E 401

Chain	Residue
E	THR139
E	ARG140
E	ARG163
E	LYS173
E	HOH2155
E	HOH2266
F	ARG104

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT F 401

Chain	Residue
E	ARG104
F	THR139
F	ARG140
F	LYS141
F	ARG163
F	LYS173
F	HOH2314
F	HOH2315

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SRT G 401

Chain	Residue
G	THR139
G	ARG140
G	ARG163
G	LYS173
G	HOH2106
G	HOH2179
G	HOH2180
G	HOH2181
H	ARG104

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SRT H 401

Chain	Residue
G	ARG104
H	THR139
H	ARG140
H	LYS141
H	ARG163
H	LYS173
H	HOH2125
H	HOH2126
H	HOH2127

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT I 401

Chain	Residue
I	THR139
I	ARG140
I	LYS141
I	ARG163
I	LYS173
I	HOH2268
I	HOH2269
J	ARG104

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT J 401

Chain	Residue
I	ARG104
J	THR139
J	ARG140
J	ARG163
J	LYS173
J	HOH2254
J	HOH2255
J	HOH2256

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SRT K 401

Chain	Residue
K	THR139
K	ARG140
K	LYS141
K	ARG163
K	LYS173
K	HOH2124
K	HOH2206
L	ARG104

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SRT L 401

Chain	Residue
K	ARG104
L	THR139
L	ARG140
L	ARG163
L	LYS173
L	HOH2148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:17868694, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY

Chain	Residue	Details
A	ARG104
J	ARG104
K	ARG104
L	ARG104
B	ARG104
C	ARG104
D	ARG104
E	ARG104
F	ARG104
G	ARG104
H	ARG104
I	ARG104

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:17868694, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	ARG140
E	HIS162
F	ARG140
F	HIS162
G	ARG140
G	HIS162
H	ARG140
H	HIS162
I	ARG140
I	HIS162
J	ARG140
A	HIS162
J	HIS162
K	ARG140
K	HIS162
L	ARG140
L	HIS162
B	ARG140
B	HIS162
C	ARG140
C	HIS162
D	ARG140
D	HIS162
E	ARG140

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0000305\|PubMed:24038671, ECO:0007744\|PDB:2JBM, ECO:0007744\|PDB:4KWW, ECO:0007744\|PDB:5AYY, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	LYS173
J	LYS173
K	LYS173
L	LYS173
B	LYS173
C	LYS173
D	LYS173
E	LYS173
F	LYS173
G	LYS173
H	LYS173
I	LYS173

site_id	SWS_FT_FI4
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:26805589, ECO:0007744\|PDB:5AYZ

Chain	Residue	Details
A	GLU203
C	ASP224
C	SER250
C	GLY272
D	GLU203
D	ASP224
D	SER250
D	GLY272
E	GLU203
E	ASP224
E	SER250
A	ASP224
E	GLY272
F	GLU203
F	ASP224
F	SER250
F	GLY272
G	GLU203
G	ASP224
G	SER250
G	GLY272
H	GLU203
A	SER250
H	ASP224
H	SER250
H	GLY272
I	GLU203
I	ASP224
I	SER250
I	GLY272
J	GLU203
J	ASP224
J	SER250
A	GLY272
J	GLY272
K	GLU203
K	ASP224
K	SER250
K	GLY272
L	GLU203
L	ASP224
L	SER250
L	GLY272
B	GLU203
B	ASP224
B	SER250
B	GLY272
C	GLU203

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
A	ASP224
A	LYS141
A	GLU203

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
J	ASP224
J	LYS141
J	GLU203

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
K	ASP224
K	LYS141
K	GLU203

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
L	ASP224
L	LYS141
L	GLU203

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
A	ARG104

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
B	ARG104

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
C	ARG104

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
D	ARG104

site_id	CSA17
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
E	ARG104

site_id	CSA18
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
F	ARG104

site_id	CSA19
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
G	ARG104

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
B	ASP224
B	LYS141
B	GLU203

site_id	CSA20
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
H	ARG104

site_id	CSA21
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
I	ARG104

site_id	CSA22
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
J	ARG104

site_id	CSA23
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
K	ARG104

site_id	CSA24
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
L	ARG104

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
C	ASP224
C	LYS141
C	GLU203

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
D	ASP224
D	LYS141
D	GLU203

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
E	ASP224
E	LYS141
E	GLU203

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
F	ASP224
F	LYS141
F	GLU203

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
G	ASP224
G	LYS141
G	GLU203

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
H	ASP224
H	LYS141
H	GLU203

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
I	ASP224
I	LYS141
I	GLU203

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)