2JAH
Biochemical and structural analysis of the Clavulanic acid dehydeogenase (CAD) from Streptomyces clavuligerus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP A 1248 |
| Chain | Residue |
| A | GLY14 |
| A | ASP64 |
| A | VAL65 |
| A | ASN91 |
| A | ALA92 |
| A | GLY93 |
| A | THR114 |
| A | MSE140 |
| A | SER141 |
| A | SER142 |
| A | TYR155 |
| A | SER16 |
| A | LYS159 |
| A | PRO185 |
| A | GLY186 |
| A | THR187 |
| A | THR188 |
| A | THR190 |
| A | GLU191 |
| A | LEU192 |
| A | HOH2045 |
| A | HOH2048 |
| A | SER17 |
| A | HOH2137 |
| A | HOH2138 |
| A | HOH2139 |
| A | HOH2140 |
| A | HOH2141 |
| A | GLY18 |
| A | ILE19 |
| A | ALA38 |
| A | ARG39 |
| A | ARG40 |
| A | LEU63 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP B 1248 |
| Chain | Residue |
| A | GLN69 |
| A | HOH2028 |
| B | GLY14 |
| B | SER16 |
| B | SER17 |
| B | GLY18 |
| B | ILE19 |
| B | ALA38 |
| B | ARG39 |
| B | ARG40 |
| B | LEU63 |
| B | ASP64 |
| B | VAL65 |
| B | ASN91 |
| B | ALA92 |
| B | GLY93 |
| B | THR114 |
| B | MSE140 |
| B | SER141 |
| B | SER142 |
| B | TYR155 |
| B | LYS159 |
| B | PRO185 |
| B | GLY186 |
| B | THR187 |
| B | THR188 |
| B | THR190 |
| B | GLU191 |
| B | LEU192 |
| B | HOH2021 |
| B | HOH2023 |
| B | HOH2049 |
| B | HOH2078 |
| B | HOH2104 |
| B | HOH2105 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP C 1248 |
| Chain | Residue |
| C | HOH2094 |
| C | HOH2103 |
| C | HOH2129 |
| C | HOH2130 |
| C | HOH2131 |
| C | GLY14 |
| C | SER16 |
| C | SER17 |
| C | GLY18 |
| C | ILE19 |
| C | ALA38 |
| C | ARG39 |
| C | ARG40 |
| C | LEU63 |
| C | ASP64 |
| C | VAL65 |
| C | ASN91 |
| C | ALA92 |
| C | GLY93 |
| C | THR114 |
| C | MSE140 |
| C | SER141 |
| C | SER142 |
| C | TYR155 |
| C | LYS159 |
| C | PRO185 |
| C | GLY186 |
| C | THR187 |
| C | THR188 |
| C | THR190 |
| C | GLU191 |
| C | LEU192 |
| C | HOH2004 |
| C | HOH2057 |
| C | HOH2080 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NDP D 1248 |
| Chain | Residue |
| D | GLY14 |
| D | SER16 |
| D | SER17 |
| D | GLY18 |
| D | ILE19 |
| D | ALA38 |
| D | ARG39 |
| D | ARG40 |
| D | LEU63 |
| D | ASP64 |
| D | VAL65 |
| D | ASN91 |
| D | ALA92 |
| D | GLY93 |
| D | THR114 |
| D | MSE140 |
| D | SER141 |
| D | SER142 |
| D | TYR155 |
| D | LYS159 |
| D | PRO185 |
| D | GLY186 |
| D | THR187 |
| D | THR188 |
| D | THR190 |
| D | GLU191 |
| D | LEU192 |
| D | HOH2003 |
| D | HOH2084 |
| D | HOH2088 |
| D | HOH2116 |
| D | HOH2117 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER142 | |
| A | TYR155 | |
| A | LYS159 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | TYR155 | |
| B | LYS159 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | TYR155 | |
| C | LYS159 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | TYR155 | |
| D | LYS159 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER142 | |
| B | TYR155 | |
| B | LYS159 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | SER142 | |
| C | TYR155 | |
| C | LYS159 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | SER142 | |
| D | TYR155 | |
| D | LYS159 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | ALA152 | |
| A | LYS159 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | ALA152 | |
| B | LYS159 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | ALA152 | |
| C | LYS159 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | ALA152 | |
| D | LYS159 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | TYR155 | |
| A | LYS159 |
