2JA3
Cytoplasmic Domain of the Human Chloride Transporter ClC-5 in complex with ADP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADP A1752 |
| Chain | Residue |
| A | LYS587 |
| A | ASP727 |
| A | LEU595 |
| A | THR596 |
| A | THR616 |
| A | TYR617 |
| A | SER618 |
| A | GLY619 |
| A | THR724 |
| A | LYS726 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADP B1754 |
| Chain | Residue |
| B | LYS587 |
| B | LEU595 |
| B | THR596 |
| B | TYR617 |
| B | SER618 |
| B | GLY619 |
| B | THR724 |
| B | LYS726 |
| B | ASP727 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ADP C1755 |
| Chain | Residue |
| C | LYS587 |
| C | LEU595 |
| C | THR596 |
| C | TYR617 |
| C | SER618 |
| C | GLY619 |
| C | PHE620 |
| C | ILE722 |
| C | THR724 |
| C | ASP727 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ADP D1753 |
| Chain | Residue |
| D | LYS587 |
| D | LEU595 |
| D | THR596 |
| D | THR616 |
| D | TYR617 |
| D | THR724 |
| D | LYS726 |
| D | ASP727 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ADP E1752 |
| Chain | Residue |
| E | LYS587 |
| E | LEU595 |
| E | THR596 |
| E | TYR617 |
| E | THR724 |
| E | LYS726 |
| E | ASP727 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ADP F1750 |
| Chain | Residue |
| F | LYS587 |
| F | THR596 |
| F | TYR617 |
| F | SER618 |
| F | THR724 |
| F | LYS726 |
| F | ASP727 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | INTRAMEM: Note=Loop between two helices => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL585-LYS587 | |
| E | GLN600-THR604 | |
| F | VAL585-LYS587 | |
| F | GLN600-THR604 | |
| A | GLN600-THR604 | |
| B | VAL585-LYS587 | |
| B | GLN600-THR604 | |
| C | VAL585-LYS587 | |
| C | GLN600-THR604 | |
| D | VAL585-LYS587 | |
| D | GLN600-THR604 | |
| E | VAL585-LYS587 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | INTRAMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| A | PRO588-THR599 | |
| B | PRO588-THR599 | |
| C | PRO588-THR599 | |
| D | PRO588-THR599 | |
| E | PRO588-THR599 | |
| F | PRO588-THR599 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL605-VAL622 | |
| B | VAL605-VAL622 | |
| C | VAL605-VAL622 | |
| D | VAL605-VAL622 | |
| E | VAL605-VAL622 | |
| F | VAL605-VAL622 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER628 | |
| B | SER628 | |
| C | SER628 | |
| D | SER628 | |
| E | SER628 | |
| F | SER628 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17195847, ECO:0007744|PDB:2J9L |
| Chain | Residue | Details |
| A | SER666 | |
| D | SER666 | |
| D | PRO687 | |
| D | THR724 | |
| E | SER666 | |
| E | PRO687 | |
| E | THR724 | |
| F | SER666 | |
| F | PRO687 | |
| F | THR724 | |
| A | PRO687 | |
| A | THR724 | |
| B | SER666 | |
| B | PRO687 | |
| B | THR724 | |
| C | SER666 | |
| C | PRO687 | |
| C | THR724 |
