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2JA1

Thymidine kinase from B. cereus with TTP bound as phosphate donor.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004797molecular_functionthymidine kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006259biological_processDNA metabolic process
A0008270molecular_functionzinc ion binding
A0009157biological_processdeoxyribonucleoside monophosphate biosynthetic process
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0046104biological_processthymidine metabolic process
A0046872molecular_functionmetal ion binding
A0071897biological_processDNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1192
ChainResidue
ACYS145
ACYS148
ACYS183
ACYS186

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE TTP A1193
ChainResidue
ASER22
AGLU23
APHE34
AVAL56
ASER57
AHIS58
AASN59
AASP88
AGLU89
AVAL144
AHOH2009
AHOH2020
ASER16
APHE18
ASER19
AGLY20
ALYS21

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MPD A1194
ChainResidue
APHE92
ALEU116
AASP119
APHE120
APHE125
AILE170
ATYR179

Functional Information from PROSITE/UniProt
site_idPS00603
Number of Residues14
DetailsTK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GasEsYePrCRhCH
ChainResidueDetails
AGLY174-HIS187

226707

PDB entries from 2024-10-30

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