2J9A

blLAP in Complex with Microginin FR1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0004180	molecular_function	carboxypeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016805	molecular_function	dipeptidase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
A	0097718	molecular_function	disordered domain specific binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1486

Chain	Residue
A	ALA333
A	ARG336
A	LEU360
D	HOH2001

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1493

Chain	Residue
A	ASP255
A	ASP332
A	GLU334
A	ZN1494
D	AHY1

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1494

Chain	Residue
A	LYS250
A	ASP255
A	ASP273
A	GLU334
A	ZN1493
D	AHY1

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMS A 1491

Chain	Residue
A	GLN79
A	ASN81
A	THR377
A	ARG399
A	MET400
A	PRO401
A	LEU402
A	PHE403
A	HOH2501

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 1492

Chain	Residue
A	GLU177
A	VAL317
A	ARG319

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AHY D 1

Chain	Residue
A	LYS250
A	ASP255
A	LYS262
A	ASP273
A	ASP332
A	GLU334
A	THR359
A	LEU360
A	ARG425
A	ALA451
A	ZN1493
A	ZN1494
D	ALA2
D	MLE3
D	HOH2001

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 1487

Chain	Residue
A	ALA48
A	TRP82
A	ASN88
A	PRO461
A	HOH2027
A	HOH2431
A	HOH2498
A	HOH2499

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1488

Chain	Residue
A	HIS233
A	TYR234
A	PRO244
A	ASN295
A	VAL297
A	HOH2322
A	HOH2381

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1489

Chain	Residue
A	PRO44
A	LEU46
A	THR51
A	ARG52
A	GLN99
A	ASP102
A	HOH2070

---

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN330-LEU337

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P28838","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
A	LYS262
A	ARG336
A	ASP255

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 587

Chain	Residue	Details
A	LYS262	electrostatic stabiliser
A	ARG336	electrostatic stabiliser

---