2J92
3C PROTEASE FROM TYPE A10(61) FOOT-AND-MOUTH DISEASE VIRUS - Crystal packing mutant (K51Q)
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease 3C activity; Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15654079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease 3C activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15654079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PDB","id":"2BHG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| A | SER182 | |
| A | HIS46 | |
| A | ALA163 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| B | SER182 | |
| B | HIS46 | |
| B | ALA163 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| A | HIS46 | proton shuttle (general acid/base) |
| A | ASP84 | electrostatic stabiliser |
| A | ALA163 | covalent catalysis |
| A | SER182 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| B | HIS46 | proton shuttle (general acid/base) |
| B | ASP84 | electrostatic stabiliser |
| B | ALA163 | covalent catalysis |
| B | SER182 | electrostatic stabiliser |
