2J8Y
Structure of PBP-A acyl-enzyme complex with penicillin-G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PNM A 1275 |
| Chain | Residue |
| A | ALA60 |
| A | THR220 |
| A | GLY221 |
| A | ASP222 |
| A | HOH2182 |
| A | SER61 |
| A | GLU96 |
| A | ALA97 |
| A | SER122 |
| A | ASN124 |
| A | MET161 |
| A | THR202 |
| A | LYS219 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PNM B 1275 |
| Chain | Residue |
| B | ALA60 |
| B | SER61 |
| B | GLU96 |
| B | ALA97 |
| B | SER122 |
| B | ASN124 |
| B | MET161 |
| B | THR202 |
| B | LYS219 |
| B | THR220 |
| B | GLY221 |
| B | ASP222 |
| B | HOH2207 |
| B | HOH2208 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PNM C 1275 |
| Chain | Residue |
| C | ALA60 |
| C | SER61 |
| C | GLU96 |
| C | ALA97 |
| C | SER122 |
| C | ASN124 |
| C | MET161 |
| C | THR202 |
| C | LYS219 |
| C | THR220 |
| C | GLY221 |
| C | ASP222 |
| C | HOH2205 |
| C | HOH2217 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PNM D 1275 |
| Chain | Residue |
| C | ARG30 |
| D | ALA60 |
| D | SER61 |
| D | GLU96 |
| D | ALA97 |
| D | SER122 |
| D | ASN124 |
| D | PRO159 |
| D | MET161 |
| D | LYS219 |
| D | THR220 |
| D | GLY221 |
| D | ASP222 |
| D | ILE223 |
| D | GLY224 |
| D | HOH2196 |
| D | HOH2205 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FNLDSGASLNVG |
| Chain | Residue | Details |
| A | PHE41-GLY52 |
