2J6L
Structure of aminoadipate-semialdehyde dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006081 | biological_process | cellular aldehyde metabolic process |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| A | 0042426 | biological_process | choline catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006081 | biological_process | cellular aldehyde metabolic process |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| B | 0042426 | biological_process | choline catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005829 | cellular_component | cytosol |
| C | 0006081 | biological_process | cellular aldehyde metabolic process |
| C | 0007605 | biological_process | sensory perception of sound |
| C | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| C | 0042426 | biological_process | choline catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005829 | cellular_component | cytosol |
| D | 0006081 | biological_process | cellular aldehyde metabolic process |
| D | 0007605 | biological_process | sensory perception of sound |
| D | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| D | 0042426 | biological_process | choline catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| E | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0005829 | cellular_component | cytosol |
| E | 0006081 | biological_process | cellular aldehyde metabolic process |
| E | 0007605 | biological_process | sensory perception of sound |
| E | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| E | 0042426 | biological_process | choline catabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| F | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005759 | cellular_component | mitochondrial matrix |
| F | 0005829 | cellular_component | cytosol |
| F | 0006081 | biological_process | cellular aldehyde metabolic process |
| F | 0007605 | biological_process | sensory perception of sound |
| F | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| F | 0042426 | biological_process | choline catabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| F | 0070062 | cellular_component | extracellular exosome |
| G | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| G | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005759 | cellular_component | mitochondrial matrix |
| G | 0005829 | cellular_component | cytosol |
| G | 0006081 | biological_process | cellular aldehyde metabolic process |
| G | 0007605 | biological_process | sensory perception of sound |
| G | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| G | 0042426 | biological_process | choline catabolic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| G | 0070062 | cellular_component | extracellular exosome |
| H | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| H | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005759 | cellular_component | mitochondrial matrix |
| H | 0005829 | cellular_component | cytosol |
| H | 0006081 | biological_process | cellular aldehyde metabolic process |
| H | 0007605 | biological_process | sensory perception of sound |
| H | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| H | 0042426 | biological_process | choline catabolic process |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| H | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR A 1502 |
| Chain | Residue |
| A | GLN349 |
| A | SER352 |
| F | MET353 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR A 1503 |
| Chain | Residue |
| A | PRO459 |
| A | GLY462 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1504 |
| Chain | Residue |
| A | HOH2502 |
| A | HOH2505 |
| A | ARG377 |
| A | GLY379 |
| A | HOH2466 |
| A | HOH2498 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR B 1502 |
| Chain | Residue |
| B | SER57 |
| B | ALA59 |
| B | BR1506 |
| B | HOH2070 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR B 1503 |
| Chain | Residue |
| E | GLN349 |
| E | SER352 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR B 1504 |
| Chain | Residue |
| A | HOH2281 |
| B | PHE293 |
| B | GLY462 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1505 |
| Chain | Residue |
| B | ARG377 |
| B | GLY379 |
| B | HOH2477 |
| B | HOH2478 |
| B | HOH2492 |
| B | HOH2493 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BR B 1506 |
| Chain | Residue |
| B | SER57 |
| B | VAL58 |
| B | ALA59 |
| B | BR1502 |
| B | HOH2125 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR C 1502 |
| Chain | Residue |
| C | PRO459 |
| C | SER461 |
| C | GLY462 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 1503 |
| Chain | Residue |
| C | ARG377 |
| C | GLY379 |
| C | HOH2441 |
| C | HOH2445 |
| C | HOH2448 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR C 1504 |
| Chain | Residue |
| E | HOH2436 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BR D 1502 |
| Chain | Residue |
| D | PRO459 |
| D | GLY462 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 1503 |
| Chain | Residue |
| D | ARG377 |
| D | GLY379 |
| D | HOH2498 |
| D | HOH2499 |
| D | HOH2500 |
| D | HOH2502 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR E 1502 |
| Chain | Residue |
| E | GLY462 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BR E 1503 |
| Chain | Residue |
| B | LYS348 |
| E | GLU359 |
| E | LYS362 |
| E | HOH2464 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BR E 1504 |
| Chain | Residue |
| C | ARG331 |
| E | PRO217 |
| E | GLY218 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA E 1505 |
| Chain | Residue |
| E | ARG377 |
| E | GLY379 |
| E | HOH2490 |
| E | HOH2491 |
| E | HOH2500 |
| E | HOH2501 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA F 1503 |
| Chain | Residue |
| F | ARG377 |
| F | GLY379 |
| F | HOH2490 |
| F | HOH2491 |
| F | HOH2498 |
| F | HOH2499 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR G 1502 |
| Chain | Residue |
| G | GLY462 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA G 1503 |
| Chain | Residue |
| G | ARG377 |
| G | GLY379 |
| G | HOH2516 |
| G | HOH2517 |
| G | HOH2522 |
| G | HOH2525 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BR H 1502 |
| Chain | Residue |
| H | GLY462 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 1503 |
| Chain | Residue |
| H | ARG377 |
| H | GLY379 |
| H | HOH2498 |
| H | HOH2504 |
| H | HOH2505 |
| site_id | CC5 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAI A 1501 |
| Chain | Residue |
| A | LEU270 |
| A | GLY271 |
| A | CYS303 |
| A | GLU400 |
| A | PHE402 |
| A | PHE469 |
| A | HOH2611 |
| A | HOH2636 |
| A | HOH2637 |
| A | HOH2638 |
| A | HOH2639 |
| A | HOH2640 |
| A | HOH2641 |
| A | HOH2643 |
| A | HOH2644 |
| A | HOH2645 |
| A | ILE164 |
| A | THR165 |
| A | ALA166 |
| A | PHE167 |
| A | ASN168 |
| A | LYS191 |
| A | GLY192 |
| A | ALA193 |
| A | PRO194 |
| A | ALA228 |
| A | GLY231 |
| A | THR232 |
| A | PHE245 |
| A | THR246 |
| A | GLY247 |
| A | SER248 |
| A | VAL251 |
| A | GLU269 |
| site_id | CC6 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAI B 1501 |
| Chain | Residue |
| B | ILE164 |
| B | THR165 |
| B | ALA166 |
| B | PHE167 |
| B | ASN168 |
| B | LYS191 |
| B | GLY192 |
| B | ALA193 |
| B | PRO194 |
| B | ALA228 |
| B | GLY231 |
| B | THR232 |
| B | PHE245 |
| B | THR246 |
| B | GLY247 |
| B | SER248 |
| B | VAL251 |
| B | GLU269 |
| B | LEU270 |
| B | GLY271 |
| B | CYS303 |
| B | GLU400 |
| B | PHE402 |
| B | PHE469 |
| B | HOH2582 |
| B | HOH2604 |
| B | HOH2605 |
| B | HOH2606 |
| B | HOH2608 |
| B | HOH2609 |
| B | HOH2610 |
| B | HOH2611 |
| B | HOH2612 |
| site_id | CC7 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAI C 1501 |
| Chain | Residue |
| C | ILE164 |
| C | THR165 |
| C | ALA166 |
| C | PHE167 |
| C | ASN168 |
| C | LYS191 |
| C | GLY192 |
| C | ALA193 |
| C | PRO194 |
| C | ALA228 |
| C | GLY231 |
| C | THR232 |
| C | PHE245 |
| C | THR246 |
| C | GLY247 |
| C | SER248 |
| C | VAL251 |
| C | VAL255 |
| C | GLU269 |
| C | LEU270 |
| C | GLY271 |
| C | CYS303 |
| C | GLU400 |
| C | PHE402 |
| C | PHE469 |
| C | HOH2545 |
| C | HOH2573 |
| C | HOH2574 |
| C | HOH2576 |
| C | HOH2578 |
| C | HOH2579 |
| C | HOH2580 |
| C | HOH2581 |
| site_id | CC8 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAI D 1501 |
| Chain | Residue |
| D | ILE164 |
| D | THR165 |
| D | ALA166 |
| D | PHE167 |
| D | ASN168 |
| D | LYS191 |
| D | GLY192 |
| D | ALA193 |
| D | PRO194 |
| D | ALA228 |
| D | GLY231 |
| D | THR232 |
| D | PHE245 |
| D | THR246 |
| D | GLY247 |
| D | SER248 |
| D | VAL251 |
| D | VAL255 |
| D | GLU269 |
| D | LEU270 |
| D | GLY271 |
| D | CYS303 |
| D | GLU400 |
| D | PHE402 |
| D | PHE469 |
| D | HOH2596 |
| D | HOH2620 |
| D | HOH2621 |
| D | HOH2622 |
| D | HOH2623 |
| D | HOH2624 |
| D | HOH2625 |
| D | HOH2626 |
| site_id | CC9 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAI E 1501 |
| Chain | Residue |
| E | ILE164 |
| E | THR165 |
| E | ALA166 |
| E | PHE167 |
| E | ASN168 |
| E | LYS191 |
| E | GLY192 |
| E | ALA193 |
| E | PRO194 |
| E | ALA228 |
| E | GLY231 |
| E | THR232 |
| E | PHE245 |
| E | THR246 |
| E | GLY247 |
| E | SER248 |
| E | VAL251 |
| E | GLU269 |
| E | LEU270 |
| E | GLY271 |
| E | CYS303 |
| E | GLU400 |
| E | PHE402 |
| E | PHE469 |
| E | HOH2605 |
| E | HOH2633 |
| E | HOH2635 |
| E | HOH2636 |
| E | HOH2637 |
| E | HOH2638 |
| E | HOH2639 |
| E | HOH2641 |
| site_id | DC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAI F 1501 |
| Chain | Residue |
| F | ILE164 |
| F | THR165 |
| F | ALA166 |
| F | PHE167 |
| F | ASN168 |
| F | LYS191 |
| F | GLY192 |
| F | ALA193 |
| F | PRO194 |
| F | ALA228 |
| F | GLY231 |
| F | THR232 |
| F | PHE245 |
| F | THR246 |
| F | GLY247 |
| F | SER248 |
| F | VAL251 |
| F | GLU269 |
| F | LEU270 |
| F | GLY271 |
| F | CYS303 |
| F | GLU400 |
| F | PHE402 |
| F | PHE469 |
| F | HOH2601 |
| F | HOH2626 |
| F | HOH2627 |
| F | HOH2628 |
| F | HOH2629 |
| F | HOH2630 |
| F | HOH2631 |
| site_id | DC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAI G 1501 |
| Chain | Residue |
| G | ILE164 |
| G | THR165 |
| G | ALA166 |
| G | PHE167 |
| G | ASN168 |
| G | LYS191 |
| G | GLY192 |
| G | ALA193 |
| G | PRO194 |
| G | ALA228 |
| G | GLY231 |
| G | THR232 |
| G | PHE245 |
| G | THR246 |
| G | GLY247 |
| G | SER248 |
| G | VAL251 |
| G | VAL255 |
| G | GLU269 |
| G | LEU270 |
| G | GLY271 |
| G | CYS303 |
| G | GLU400 |
| G | PHE402 |
| G | PHE469 |
| G | HOH2429 |
| G | HOH2617 |
| G | HOH2646 |
| G | HOH2647 |
| G | HOH2648 |
| G | HOH2649 |
| G | HOH2651 |
| G | HOH2653 |
| site_id | DC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAI H 1501 |
| Chain | Residue |
| H | ILE164 |
| H | THR165 |
| H | ALA166 |
| H | PHE167 |
| H | ASN168 |
| H | LYS191 |
| H | GLY192 |
| H | ALA193 |
| H | PRO194 |
| H | ALA228 |
| H | GLY231 |
| H | THR232 |
| H | PHE245 |
| H | THR246 |
| H | GLY247 |
| H | SER248 |
| H | VAL251 |
| H | VAL255 |
| H | GLU269 |
| H | LEU270 |
| H | GLY271 |
| H | CYS303 |
| H | GLU400 |
| H | PHE402 |
| H | PHE469 |
| H | HOH2607 |
| H | HOH2632 |
| H | HOH2633 |
| H | HOH2634 |
| H | HOH2635 |
| H | HOH2636 |
| H | HOH2637 |
| H | HOH2638 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA |
| Chain | Residue | Details |
| A | LEU268-ALA275 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007 |
| Chain | Residue | Details |
| A | THR298 | |
| B | THR298 | |
| C | THR298 | |
| D | THR298 | |
| E | THR298 | |
| F | THR298 | |
| G | THR298 | |
| H | THR298 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:26260980 |
| Chain | Residue | Details |
| A | VAL332 | |
| B | VAL332 | |
| C | VAL332 | |
| D | VAL332 | |
| E | VAL332 | |
| F | VAL332 | |
| G | VAL332 | |
| H | VAL332 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:26260980, ECO:0007744|PDB:2J6L, ECO:0007744|PDB:4X0T, ECO:0007744|PDB:4ZUK, ECO:0007744|PDB:4ZVY |
| Chain | Residue | Details |
| A | PRO194 | |
| C | ILE220 | |
| C | GLN260 | |
| C | ILE276 | |
| D | PRO194 | |
| D | ILE220 | |
| D | GLN260 | |
| D | ILE276 | |
| E | PRO194 | |
| E | ILE220 | |
| E | GLN260 | |
| A | ILE220 | |
| E | ILE276 | |
| F | PRO194 | |
| F | ILE220 | |
| F | GLN260 | |
| F | ILE276 | |
| G | PRO194 | |
| G | ILE220 | |
| G | GLN260 | |
| G | ILE276 | |
| H | PRO194 | |
| A | GLN260 | |
| H | ILE220 | |
| H | GLN260 | |
| H | ILE276 | |
| A | ILE276 | |
| B | PRO194 | |
| B | ILE220 | |
| B | GLN260 | |
| B | ILE276 | |
| C | PRO194 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:26260980, ECO:0007744|PDB:2J6L, ECO:0007744|PDB:4X0T |
| Chain | Residue | Details |
| A | THR298 | |
| E | SER429 | |
| F | THR298 | |
| F | SER429 | |
| G | THR298 | |
| G | SER429 | |
| H | THR298 | |
| H | SER429 | |
| A | SER429 | |
| B | THR298 | |
| B | SER429 | |
| C | THR298 | |
| C | SER429 | |
| D | THR298 | |
| D | SER429 | |
| E | THR298 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4ZUL |
| Chain | Residue | Details |
| A | GLY333 | |
| D | GLY333 | |
| D | ARG491 | |
| D | ARG492 | |
| E | GLY333 | |
| E | ARG491 | |
| E | ARG492 | |
| F | GLY333 | |
| F | ARG491 | |
| F | ARG492 | |
| G | GLY333 | |
| A | ARG491 | |
| G | ARG491 | |
| G | ARG492 | |
| H | GLY333 | |
| H | ARG491 | |
| H | ARG492 | |
| A | ARG492 | |
| B | GLY333 | |
| B | ARG491 | |
| B | ARG492 | |
| C | GLY333 | |
| C | ARG491 | |
| C | ARG492 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | SER197 | |
| B | SER197 | |
| C | SER197 | |
| D | SER197 | |
| E | SER197 | |
| F | SER197 | |
| G | SER197 | |
| H | SER197 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBF1 |
| Chain | Residue | Details |
| A | GLU96 | |
| B | GLU96 | |
| C | GLU96 | |
| D | GLU96 | |
| E | GLU96 | |
| F | GLU96 | |
| G | GLU96 | |
| H | GLU96 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBF1 |
| Chain | Residue | Details |
| A | GLU464 | |
| E | LYS473 | |
| F | GLU464 | |
| F | LYS473 | |
| G | GLU464 | |
| G | LYS473 | |
| H | GLU464 | |
| H | LYS473 | |
| A | LYS473 | |
| B | GLU464 | |
| B | LYS473 | |
| C | GLU464 | |
| C | LYS473 | |
| D | GLU464 | |
| D | LYS473 | |
| E | GLU464 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | GLU269 | |
| A | CYS303 | |
| A | ASN168 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | GLU269 | |
| B | CYS303 | |
| B | ASN168 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | GLU269 | |
| C | CYS303 | |
| C | ASN168 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | GLU269 | |
| D | CYS303 | |
| D | ASN168 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| E | GLU269 | |
| E | CYS303 | |
| E | ASN168 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| F | GLU269 | |
| F | CYS303 | |
| F | ASN168 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| G | GLU269 | |
| G | CYS303 | |
| G | ASN168 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| H | GLU269 | |
| H | CYS303 | |
| H | ASN168 |
