2J6L

Structure of aminoadipate-semialdehyde dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006081	biological_process	aldehyde metabolic process
A	0006554	biological_process	lysine catabolic process
A	0007605	biological_process	sensory perception of sound
A	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019285	biological_process	glycine betaine biosynthetic process from choline
A	0019477	biological_process	L-lysine catabolic process
A	0042426	biological_process	choline catabolic process
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006081	biological_process	aldehyde metabolic process
B	0006554	biological_process	lysine catabolic process
B	0007605	biological_process	sensory perception of sound
B	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019285	biological_process	glycine betaine biosynthetic process from choline
B	0019477	biological_process	L-lysine catabolic process
B	0042426	biological_process	choline catabolic process
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006081	biological_process	aldehyde metabolic process
C	0006554	biological_process	lysine catabolic process
C	0007605	biological_process	sensory perception of sound
C	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019285	biological_process	glycine betaine biosynthetic process from choline
C	0019477	biological_process	L-lysine catabolic process
C	0042426	biological_process	choline catabolic process
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006081	biological_process	aldehyde metabolic process
D	0006554	biological_process	lysine catabolic process
D	0007605	biological_process	sensory perception of sound
D	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019285	biological_process	glycine betaine biosynthetic process from choline
D	0019477	biological_process	L-lysine catabolic process
D	0042426	biological_process	choline catabolic process
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006081	biological_process	aldehyde metabolic process
E	0006554	biological_process	lysine catabolic process
E	0007605	biological_process	sensory perception of sound
E	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0019285	biological_process	glycine betaine biosynthetic process from choline
E	0019477	biological_process	L-lysine catabolic process
E	0042426	biological_process	choline catabolic process
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006081	biological_process	aldehyde metabolic process
F	0006554	biological_process	lysine catabolic process
F	0007605	biological_process	sensory perception of sound
F	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0019285	biological_process	glycine betaine biosynthetic process from choline
F	0019477	biological_process	L-lysine catabolic process
F	0042426	biological_process	choline catabolic process
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006081	biological_process	aldehyde metabolic process
G	0006554	biological_process	lysine catabolic process
G	0007605	biological_process	sensory perception of sound
G	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0019285	biological_process	glycine betaine biosynthetic process from choline
G	0019477	biological_process	L-lysine catabolic process
G	0042426	biological_process	choline catabolic process
G	0042802	molecular_function	identical protein binding
G	0070062	cellular_component	extracellular exosome
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006081	biological_process	aldehyde metabolic process
H	0006554	biological_process	lysine catabolic process
H	0007605	biological_process	sensory perception of sound
H	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0019285	biological_process	glycine betaine biosynthetic process from choline
H	0019477	biological_process	L-lysine catabolic process
H	0042426	biological_process	choline catabolic process
H	0042802	molecular_function	identical protein binding
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 1502

Chain	Residue
A	GLN349
A	SER352
F	MET353

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 1503

Chain	Residue
A	PRO459
A	GLY462

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1504

Chain	Residue
A	HOH2502
A	HOH2505
A	ARG377
A	GLY379
A	HOH2466
A	HOH2498

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR B 1502

Chain	Residue
B	SER57
B	ALA59
B	BR1506
B	HOH2070

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 1503

Chain	Residue
E	GLN349
E	SER352

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 1504

Chain	Residue
A	HOH2281
B	PHE293
B	GLY462

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 1505

Chain	Residue
B	ARG377
B	GLY379
B	HOH2477
B	HOH2478
B	HOH2492
B	HOH2493

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR B 1506

Chain	Residue
B	SER57
B	VAL58
B	ALA59
B	BR1502
B	HOH2125

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR C 1502

Chain	Residue
C	PRO459
C	SER461
C	GLY462

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 1503

Chain	Residue
C	ARG377
C	GLY379
C	HOH2441
C	HOH2445
C	HOH2448

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 1504

Chain	Residue
E	HOH2436

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR D 1502

Chain	Residue
D	PRO459
D	GLY462

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 1503

Chain	Residue
D	ARG377
D	GLY379
D	HOH2498
D	HOH2499
D	HOH2500
D	HOH2502

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR E 1502

Chain	Residue
E	GLY462

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR E 1503

Chain	Residue
B	LYS348
E	GLU359
E	LYS362
E	HOH2464

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR E 1504

Chain	Residue
C	ARG331
E	PRO217
E	GLY218

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 1505

Chain	Residue
E	ARG377
E	GLY379
E	HOH2490
E	HOH2491
E	HOH2500
E	HOH2501

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 1503

Chain	Residue
F	ARG377
F	GLY379
F	HOH2490
F	HOH2491
F	HOH2498
F	HOH2499

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR G 1502

Chain	Residue
G	GLY462

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA G 1503

Chain	Residue
G	ARG377
G	GLY379
G	HOH2516
G	HOH2517
G	HOH2522
G	HOH2525

---

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR H 1502

Chain	Residue
H	GLY462

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA H 1503

Chain	Residue
H	ARG377
H	GLY379
H	HOH2498
H	HOH2504
H	HOH2505

---

site_id	CC5
Number of Residues	34
Details	BINDING SITE FOR RESIDUE NAI A 1501

Chain	Residue
A	LEU270
A	GLY271
A	CYS303
A	GLU400
A	PHE402
A	PHE469
A	HOH2611
A	HOH2636
A	HOH2637
A	HOH2638
A	HOH2639
A	HOH2640
A	HOH2641
A	HOH2643
A	HOH2644
A	HOH2645
A	ILE164
A	THR165
A	ALA166
A	PHE167
A	ASN168
A	LYS191
A	GLY192
A	ALA193
A	PRO194
A	ALA228
A	GLY231
A	THR232
A	PHE245
A	THR246
A	GLY247
A	SER248
A	VAL251
A	GLU269

---

site_id	CC6
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAI B 1501

Chain	Residue
B	ILE164
B	THR165
B	ALA166
B	PHE167
B	ASN168
B	LYS191
B	GLY192
B	ALA193
B	PRO194
B	ALA228
B	GLY231
B	THR232
B	PHE245
B	THR246
B	GLY247
B	SER248
B	VAL251
B	GLU269
B	LEU270
B	GLY271
B	CYS303
B	GLU400
B	PHE402
B	PHE469
B	HOH2582
B	HOH2604
B	HOH2605
B	HOH2606
B	HOH2608
B	HOH2609
B	HOH2610
B	HOH2611
B	HOH2612

---

site_id	CC7
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAI C 1501

Chain	Residue
C	ILE164
C	THR165
C	ALA166
C	PHE167
C	ASN168
C	LYS191
C	GLY192
C	ALA193
C	PRO194
C	ALA228
C	GLY231
C	THR232
C	PHE245
C	THR246
C	GLY247
C	SER248
C	VAL251
C	VAL255
C	GLU269
C	LEU270
C	GLY271
C	CYS303
C	GLU400
C	PHE402
C	PHE469
C	HOH2545
C	HOH2573
C	HOH2574
C	HOH2576
C	HOH2578
C	HOH2579
C	HOH2580
C	HOH2581

---

site_id	CC8
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAI D 1501

Chain	Residue
D	ILE164
D	THR165
D	ALA166
D	PHE167
D	ASN168
D	LYS191
D	GLY192
D	ALA193
D	PRO194
D	ALA228
D	GLY231
D	THR232
D	PHE245
D	THR246
D	GLY247
D	SER248
D	VAL251
D	VAL255
D	GLU269
D	LEU270
D	GLY271
D	CYS303
D	GLU400
D	PHE402
D	PHE469
D	HOH2596
D	HOH2620
D	HOH2621
D	HOH2622
D	HOH2623
D	HOH2624
D	HOH2625
D	HOH2626

---

site_id	CC9
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAI E 1501

Chain	Residue
E	ILE164
E	THR165
E	ALA166
E	PHE167
E	ASN168
E	LYS191
E	GLY192
E	ALA193
E	PRO194
E	ALA228
E	GLY231
E	THR232
E	PHE245
E	THR246
E	GLY247
E	SER248
E	VAL251
E	GLU269
E	LEU270
E	GLY271
E	CYS303
E	GLU400
E	PHE402
E	PHE469
E	HOH2605
E	HOH2633
E	HOH2635
E	HOH2636
E	HOH2637
E	HOH2638
E	HOH2639
E	HOH2641

---

site_id	DC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAI F 1501

Chain	Residue
F	ILE164
F	THR165
F	ALA166
F	PHE167
F	ASN168
F	LYS191
F	GLY192
F	ALA193
F	PRO194
F	ALA228
F	GLY231
F	THR232
F	PHE245
F	THR246
F	GLY247
F	SER248
F	VAL251
F	GLU269
F	LEU270
F	GLY271
F	CYS303
F	GLU400
F	PHE402
F	PHE469
F	HOH2601
F	HOH2626
F	HOH2627
F	HOH2628
F	HOH2629
F	HOH2630
F	HOH2631

---

site_id	DC2
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAI G 1501

Chain	Residue
G	ILE164
G	THR165
G	ALA166
G	PHE167
G	ASN168
G	LYS191
G	GLY192
G	ALA193
G	PRO194
G	ALA228
G	GLY231
G	THR232
G	PHE245
G	THR246
G	GLY247
G	SER248
G	VAL251
G	VAL255
G	GLU269
G	LEU270
G	GLY271
G	CYS303
G	GLU400
G	PHE402
G	PHE469
G	HOH2429
G	HOH2617
G	HOH2646
G	HOH2647
G	HOH2648
G	HOH2649
G	HOH2651
G	HOH2653

---

site_id	DC3
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAI H 1501

Chain	Residue
H	ILE164
H	THR165
H	ALA166
H	PHE167
H	ASN168
H	LYS191
H	GLY192
H	ALA193
H	PRO194
H	ALA228
H	GLY231
H	THR232
H	PHE245
H	THR246
H	GLY247
H	SER248
H	VAL251
H	VAL255
H	GLU269
H	LEU270
H	GLY271
H	CYS303
H	GLU400
H	PHE402
H	PHE469
H	HOH2607
H	HOH2632
H	HOH2633
H	HOH2634
H	HOH2635
H	HOH2636
H	HOH2637
H	HOH2638

---

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA

Chain	Residue	Details
A	LEU268-ALA275

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20207735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZVY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20207735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X0T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PDB","id":"4ZUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DBF1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBF1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	GLU269
A	CYS303
A	ASN168

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	GLU269
B	CYS303
B	ASN168

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	GLU269
C	CYS303
C	ASN168

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	GLU269
D	CYS303
D	ASN168

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
E	GLU269
E	CYS303
E	ASN168

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
F	GLU269
F	CYS303
F	ASN168

---

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
G	GLU269
G	CYS303
G	ASN168

---

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
H	GLU269
H	CYS303
H	ASN168

---