2J65
Structure of LpxC from Aquifex aeolicus in complex with UDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006796 | biological_process | phosphate-containing compound metabolic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019637 | biological_process | organophosphate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS74 |
| A | THR179 |
| A | HIS226 |
| A | ASP230 |
| A | ZN302 |
| A | HOH2238 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | MYR401 |
| A | HOH2238 |
| A | GLU73 |
| A | HIS253 |
| A | ZN301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | HIS58 |
| A | HIS188 |
| A | CL305 |
| A | HOH2239 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 304 |
| Chain | Residue |
| A | GLY2 |
| A | GLU120 |
| B | HIS29 |
| B | GLU90 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | ASN57 |
| A | HIS58 |
| A | PHE158 |
| A | ZN303 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS74 |
| B | HIS226 |
| B | ASP230 |
| B | ZN302 |
| B | HOH2238 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | GLU73 |
| B | HIS253 |
| B | ZN301 |
| B | HOH2238 |
| B | HOH2239 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 303 |
| Chain | Residue |
| B | HIS58 |
| B | HIS188 |
| B | CL304 |
| B | HOH2240 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 304 |
| Chain | Residue |
| B | ASN57 |
| B | HIS58 |
| B | PHE158 |
| B | HIS188 |
| B | ZN303 |
| B | HOH2207 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MYR A 401 |
| Chain | Residue |
| A | HIS58 |
| A | SER59 |
| A | GLU73 |
| A | GLY198 |
| A | HIS253 |
| A | ZN302 |
| A | HOH2238 |
| A | HOH2241 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE UDP A 402 |
| Chain | Residue |
| A | ARG137 |
| A | TYR151 |
| A | GLY153 |
| A | GLU154 |
| A | PHE155 |
| A | LYS156 |
| A | GLU185 |
| A | LYS227 |
| A | ARG250 |
| A | GLY251 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MYR B 401 |
| Chain | Residue |
| A | ILE186 |
| A | TYR212 |
| B | ILE186 |
| B | GLY195 |
| B | HOH2241 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UDP B 402 |
| Chain | Residue |
| B | ARG137 |
| B | TYR151 |
| B | GLY153 |
| B | GLU154 |
| B | PHE155 |
| B | LYS156 |
| B | GLU185 |
| B | LYS227 |
| B | ARG250 |
| B | HOH2242 |
| B | HOH2243 |
| B | HOH2244 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MYR B 403 |
| Chain | Residue |
| A | SER199 |
| A | HOH2177 |
| B | THR179 |
| B | ILE186 |
| B | GLY198 |
| B | SER199 |
| B | LEU200 |
| B | HOH2245 |
| B | HOH2246 |
| B | HOH2247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15705580","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00388","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12819349","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15705580","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
