2J5W
Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00079 |
| Number of Residues | 21 |
| Details | MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GeWmLsCqNLnhLkAGLqafF |
| Chain | Residue | Details |
| A | GLY313-PHE333 | |
| A | GLY674-TYR694 | |
| A | GLY1015-TYR1035 |
| site_id | PS00080 |
| Number of Residues | 12 |
| Details | MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHvtdHihaGM |
| Chain | Residue | Details |
| A | HIS1020-MET1031 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for glutathione peroxidase activity => ECO:0000269|PubMed:10508415 |
| Chain | Residue | Details |
| A | CYS680 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:23843990, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | TYR36 | |
| A | SER237 | |
| A | HIS978 | |
| A | HIS1022 | |
| A | GLY45 | |
| A | TYR48 | |
| A | HIS101 | |
| A | LYS109 | |
| A | GLN124 | |
| A | ASP127 | |
| A | ASP128 | |
| A | HIS161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: type 3 copper site => ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:23843990, ECO:0000269|Ref.29, ECO:0007744|PDB:1KCW, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4EJX, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | HIS103 | |
| A | HIS163 | |
| A | HIS1020 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | BINDING: type 1 copper site => ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:23843990, ECO:0000269|Ref.29, ECO:0007744|PDB:1KCW, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | HIS276 | |
| A | CYS319 | |
| A | HIS324 | |
| A | HIS637 | |
| A | CYS680 | |
| A | HIS685 | |
| A | MET690 | |
| A | HIS1026 | |
| A | MET1031 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17242517, ECO:0007744|PDB:2J5W |
| Chain | Residue | Details |
| A | PHE389 | |
| A | GLY398 | |
| A | TYR401 | |
| A | SER598 | |
| A | PHE748 | |
| A | GLY757 | |
| A | TYR760 | |
| A | SER936 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: type 1 copper site => ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:23843990, ECO:0000269|Ref.29, ECO:0007744|PDB:1KCW, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4EJX, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | HIS975 | |
| A | CYS1021 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23843990, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | HIS980 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 |
| Chain | Residue | Details |
| A | SER703 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:23843990, ECO:0000269|Ref.29, ECO:0007744|PDB:1KCW, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4EJX, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | ASN119 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169 |
| Chain | Residue | Details |
| A | ASN339 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17242517, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:23843990, ECO:0007744|PDB:2J5W, ECO:0007744|PDB:4EJX, ECO:0007744|PDB:4ENZ |
| Chain | Residue | Details |
| A | ASN378 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN569 | |
| A | ASN907 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|Ref.29, ECO:0007744|PDB:1KCW |
| Chain | Residue | Details |
| A | ASN743 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a65 |
| Chain | Residue | Details |
| A | HIS1020 | |
| A | HIS1022 | |
| A | CYS1021 |
