2J5I
Crystal Structure of Hydroxycinnamoyl-CoA Hydratase-Lyase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008300 | biological_process | isoprenoid catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008300 | biological_process | isoprenoid catabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0008300 | biological_process | isoprenoid catabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008300 | biological_process | isoprenoid catabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0008300 | biological_process | isoprenoid catabolic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0008300 | biological_process | isoprenoid catabolic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0008300 | biological_process | isoprenoid catabolic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0008300 | biological_process | isoprenoid catabolic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0008300 | biological_process | isoprenoid catabolic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0008300 | biological_process | isoprenoid catabolic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0008300 | biological_process | isoprenoid catabolic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0008300 | biological_process | isoprenoid catabolic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0050547 | molecular_function | feruloyl-CoA hydratase/lyase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00166 |
| Number of Residues | 21 |
| Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAmVNGwcfGGGfsplVaCDL |
| Chain | Residue | Details |
| B | ILE110-LEU130 | |
| A | ILE110-LEU130 | |
| I | ILE110-LEU130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18479250","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VSS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VSU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18479250","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VSS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| B | GLY120 | |
| B | GLU143 | |
| B | SER123 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| L | GLY120 | |
| L | GLU143 | |
| L | SER123 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| I | GLY120 | |
| I | GLU143 | |
| I | SER123 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| A | GLY120 | |
| A | GLU143 | |
| A | SER123 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| A | GLU143 | |
| A | GLY151 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| B | GLU143 | |
| B | GLY151 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| C | GLU143 | |
| C | GLY151 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| D | GLU143 | |
| D | GLY151 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| E | GLU143 | |
| E | GLY151 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| F | GLU143 | |
| F | GLY151 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| G | GLU143 | |
| G | GLY151 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| C | GLY120 | |
| C | GLU143 | |
| C | SER123 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| H | GLU143 | |
| H | GLY151 |
| site_id | CSA21 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| J | GLU143 | |
| J | GLY151 |
| site_id | CSA22 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| K | GLU143 | |
| K | GLY151 |
| site_id | CSA23 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| L | GLU143 | |
| L | GLY151 |
| site_id | CSA24 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| I | GLU143 | |
| I | GLY151 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| D | GLY120 | |
| D | GLU143 | |
| D | SER123 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| E | GLY120 | |
| E | GLU143 | |
| E | SER123 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| F | GLY120 | |
| F | GLU143 | |
| F | SER123 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| G | GLY120 | |
| G | GLU143 | |
| G | SER123 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| H | GLY120 | |
| H | GLU143 | |
| H | SER123 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| J | GLY120 | |
| J | GLU143 | |
| J | SER123 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| K | GLY120 | |
| K | GLU143 | |
| K | SER123 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| I | MET70 | electrostatic stabiliser, hydrogen bond donor |
| I | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| I | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| I | GLU143 | activator, proton acceptor, proton donor |
| I | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA10 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| L | MET70 | electrostatic stabiliser, hydrogen bond donor |
| L | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| L | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| L | GLU143 | activator, proton acceptor, proton donor |
| L | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| C | MET70 | electrostatic stabiliser, hydrogen bond donor |
| C | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| C | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| C | GLU143 | activator, proton acceptor, proton donor |
| C | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| D | MET70 | electrostatic stabiliser, hydrogen bond donor |
| D | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| D | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| D | GLU143 | activator, proton acceptor, proton donor |
| D | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| E | MET70 | electrostatic stabiliser, hydrogen bond donor |
| E | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| E | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| E | GLU143 | activator, proton acceptor, proton donor |
| E | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| F | MET70 | electrostatic stabiliser, hydrogen bond donor |
| F | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| F | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| F | GLU143 | activator, proton acceptor, proton donor |
| F | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| G | MET70 | electrostatic stabiliser, hydrogen bond donor |
| G | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| G | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| G | GLU143 | activator, proton acceptor, proton donor |
| G | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA7 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| H | MET70 | electrostatic stabiliser, hydrogen bond donor |
| H | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| H | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| H | GLU143 | activator, proton acceptor, proton donor |
| H | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA8 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| J | MET70 | electrostatic stabiliser, hydrogen bond donor |
| J | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| J | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| J | GLU143 | activator, proton acceptor, proton donor |
| J | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
| site_id | MCSA9 |
| Number of Residues | 5 |
| Details | M-CSA 347 |
| Chain | Residue | Details |
| K | MET70 | electrostatic stabiliser, hydrogen bond donor |
| K | TYR75 | electrostatic stabiliser, hydrogen bond donor, steric role |
| K | GLY120 | electrostatic stabiliser, hydrogen bond donor |
| K | GLU143 | activator, proton acceptor, proton donor |
| K | TYR239 | electrostatic stabiliser, hydrogen bond donor, steric role |
