2J4L
Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UTP to 2.8 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006225 | biological_process | UDP biosynthetic process |
| A | 0009041 | molecular_function | UMP/dUMP kinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0033862 | molecular_function | UMP kinase activity |
| A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006225 | biological_process | UDP biosynthetic process |
| B | 0009041 | molecular_function | UMP/dUMP kinase activity |
| B | 0016301 | molecular_function | kinase activity |
| B | 0033862 | molecular_function | UMP kinase activity |
| B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006225 | biological_process | UDP biosynthetic process |
| C | 0009041 | molecular_function | UMP/dUMP kinase activity |
| C | 0016301 | molecular_function | kinase activity |
| C | 0033862 | molecular_function | UMP kinase activity |
| C | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| C | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006225 | biological_process | UDP biosynthetic process |
| D | 0009041 | molecular_function | UMP/dUMP kinase activity |
| D | 0016301 | molecular_function | kinase activity |
| D | 0033862 | molecular_function | UMP kinase activity |
| D | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| D | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0006225 | biological_process | UDP biosynthetic process |
| E | 0009041 | molecular_function | UMP/dUMP kinase activity |
| E | 0016301 | molecular_function | kinase activity |
| E | 0033862 | molecular_function | UMP kinase activity |
| E | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| E | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0006225 | biological_process | UDP biosynthetic process |
| F | 0009041 | molecular_function | UMP/dUMP kinase activity |
| F | 0016301 | molecular_function | kinase activity |
| F | 0033862 | molecular_function | UMP kinase activity |
| F | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| F | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| G | 0006225 | biological_process | UDP biosynthetic process |
| G | 0009041 | molecular_function | UMP/dUMP kinase activity |
| G | 0016301 | molecular_function | kinase activity |
| G | 0033862 | molecular_function | UMP kinase activity |
| G | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| G | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| H | 0006225 | biological_process | UDP biosynthetic process |
| H | 0009041 | molecular_function | UMP/dUMP kinase activity |
| H | 0016301 | molecular_function | kinase activity |
| H | 0033862 | molecular_function | UMP kinase activity |
| H | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| H | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| I | 0006225 | biological_process | UDP biosynthetic process |
| I | 0009041 | molecular_function | UMP/dUMP kinase activity |
| I | 0016301 | molecular_function | kinase activity |
| I | 0033862 | molecular_function | UMP kinase activity |
| I | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| I | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| J | 0006225 | biological_process | UDP biosynthetic process |
| J | 0009041 | molecular_function | UMP/dUMP kinase activity |
| J | 0016301 | molecular_function | kinase activity |
| J | 0033862 | molecular_function | UMP kinase activity |
| J | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| J | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| K | 0006225 | biological_process | UDP biosynthetic process |
| K | 0009041 | molecular_function | UMP/dUMP kinase activity |
| K | 0016301 | molecular_function | kinase activity |
| K | 0033862 | molecular_function | UMP kinase activity |
| K | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| K | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| L | 0006225 | biological_process | UDP biosynthetic process |
| L | 0009041 | molecular_function | UMP/dUMP kinase activity |
| L | 0016301 | molecular_function | kinase activity |
| L | 0033862 | molecular_function | UMP kinase activity |
| L | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| L | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG B1228 |
| Chain | Residue |
| B | UTP1227 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C1228 |
| Chain | Residue |
| C | ARG48 |
| C | UTP1227 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG D1228 |
| Chain | Residue |
| D | UTP1227 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E1228 |
| Chain | Residue |
| E | TYR181 |
| E | UTP1227 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG I1228 |
| Chain | Residue |
| I | UTP1227 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG J1228 |
| Chain | Residue |
| J | UTP1227 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG L1228 |
| Chain | Residue |
| L | UTP1227 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UTP A1227 |
| Chain | Residue |
| A | LYS6 |
| A | SER8 |
| A | GLY9 |
| A | GLY42 |
| A | GLY43 |
| A | ASP65 |
| A | GLY68 |
| A | ILE69 |
| A | GLY112 |
| A | PHE113 |
| A | GLN114 |
| A | PRO115 |
| A | GLN117 |
| A | SER118 |
| A | THR119 |
| A | VAL122 |
| A | LEU183 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UTP B1227 |
| Chain | Residue |
| B | LYS6 |
| B | SER8 |
| B | GLY9 |
| B | LYS10 |
| B | GLY42 |
| B | GLY43 |
| B | GLY44 |
| B | ASP65 |
| B | GLY68 |
| B | ILE69 |
| B | GLY112 |
| B | PHE113 |
| B | GLN114 |
| B | PRO115 |
| B | GLN117 |
| B | SER118 |
| B | THR119 |
| B | VAL122 |
| B | MG1228 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE UTP C1227 |
| Chain | Residue |
| C | LYS6 |
| C | SER8 |
| C | GLY9 |
| C | GLY42 |
| C | GLY43 |
| C | GLY44 |
| C | ARG48 |
| C | ILE51 |
| C | ASP65 |
| C | GLY68 |
| C | ILE69 |
| C | GLY112 |
| C | PHE113 |
| C | GLN114 |
| C | PRO115 |
| C | GLN117 |
| C | SER118 |
| C | THR119 |
| C | VAL122 |
| C | ALA178 |
| C | GLY179 |
| C | MG1228 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UTP D1227 |
| Chain | Residue |
| D | LYS6 |
| D | SER8 |
| D | GLY9 |
| D | GLY42 |
| D | GLY43 |
| D | GLY44 |
| D | ASP65 |
| D | GLY68 |
| D | ILE69 |
| D | GLY112 |
| D | PHE113 |
| D | GLN114 |
| D | PRO115 |
| D | GLY116 |
| D | GLN117 |
| D | SER118 |
| D | THR119 |
| D | VAL122 |
| D | MG1228 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE UTP E1227 |
| Chain | Residue |
| E | PRO115 |
| E | GLN117 |
| E | SER118 |
| E | THR119 |
| E | VAL122 |
| E | ALA178 |
| E | GLY179 |
| E | TYR181 |
| E | MG1228 |
| E | LYS6 |
| E | SER8 |
| E | GLY9 |
| E | GLY42 |
| E | GLY43 |
| E | GLY44 |
| E | ILE51 |
| E | ASP65 |
| E | GLY68 |
| E | ILE69 |
| E | GLY112 |
| E | PHE113 |
| E | GLN114 |
| site_id | BC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UTP F1227 |
| Chain | Residue |
| F | LYS6 |
| F | SER8 |
| F | GLY9 |
| F | GLY42 |
| F | GLY43 |
| F | GLY44 |
| F | ASP65 |
| F | GLY68 |
| F | ILE69 |
| F | GLY112 |
| F | PHE113 |
| F | GLN114 |
| F | PRO115 |
| F | GLN117 |
| F | SER118 |
| F | THR119 |
| F | VAL122 |
| F | GLY179 |
| F | TYR181 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UTP G1227 |
| Chain | Residue |
| G | LYS6 |
| G | SER8 |
| G | GLY9 |
| G | GLY42 |
| G | GLY43 |
| G | GLY44 |
| G | ILE51 |
| G | ASP65 |
| G | ILE69 |
| G | GLY112 |
| G | PHE113 |
| G | GLN114 |
| G | GLN117 |
| G | SER118 |
| G | THR119 |
| G | VAL122 |
| site_id | BC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UTP H1227 |
| Chain | Residue |
| H | LYS6 |
| H | SER8 |
| H | GLY9 |
| H | GLY42 |
| H | GLY43 |
| H | GLY44 |
| H | ARG48 |
| H | ILE51 |
| H | ASP65 |
| H | ILE69 |
| H | GLY112 |
| H | PHE113 |
| H | GLN114 |
| H | PRO115 |
| H | GLN117 |
| H | SER118 |
| H | THR119 |
| H | VAL122 |
| site_id | BC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UTP I1227 |
| Chain | Residue |
| I | LYS6 |
| I | SER8 |
| I | GLY9 |
| I | GLY42 |
| I | GLY43 |
| I | GLY44 |
| I | ASP65 |
| I | GLY68 |
| I | ILE69 |
| I | GLY112 |
| I | PHE113 |
| I | GLN114 |
| I | PRO115 |
| I | GLN117 |
| I | SER118 |
| I | THR119 |
| I | VAL122 |
| I | MG1228 |
| site_id | BC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UTP J1227 |
| Chain | Residue |
| J | LYS6 |
| J | SER8 |
| J | GLY9 |
| J | GLY43 |
| J | ILE51 |
| J | ASP65 |
| J | GLY68 |
| J | ILE69 |
| J | GLY112 |
| J | PHE113 |
| J | GLN114 |
| J | PRO115 |
| J | GLN117 |
| J | SER118 |
| J | THR119 |
| J | VAL122 |
| J | MG1228 |
| site_id | BC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UTP K1227 |
| Chain | Residue |
| K | GLY42 |
| K | GLY43 |
| K | ASP65 |
| K | GLY68 |
| K | ILE69 |
| K | GLY112 |
| K | PHE113 |
| K | GLN114 |
| K | PRO115 |
| K | GLN117 |
| K | SER118 |
| K | THR119 |
| K | VAL122 |
| site_id | CC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UTP L1227 |
| Chain | Residue |
| L | LYS6 |
| L | SER8 |
| L | GLY9 |
| L | GLY42 |
| L | GLY43 |
| L | GLY44 |
| L | ASP65 |
| L | GLY68 |
| L | ILE69 |
| L | GLY112 |
| L | PHE113 |
| L | GLN114 |
| L | PRO115 |
| L | GLN117 |
| L | SER118 |
| L | THR119 |
| L | VAL122 |
| L | MG1228 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS6 | |
| B | ARG48 | |
| B | THR139 | |
| B | ASN140 | |
| B | TYR145 | |
| B | ASP148 | |
| C | LYS6 | |
| C | GLY44 | |
| C | ARG48 | |
| C | THR139 | |
| C | ASN140 | |
| A | GLY44 | |
| C | TYR145 | |
| C | ASP148 | |
| D | LYS6 | |
| D | GLY44 | |
| D | ARG48 | |
| D | THR139 | |
| D | ASN140 | |
| D | TYR145 | |
| D | ASP148 | |
| E | LYS6 | |
| A | ARG48 | |
| E | GLY44 | |
| E | ARG48 | |
| E | THR139 | |
| E | ASN140 | |
| E | TYR145 | |
| E | ASP148 | |
| F | LYS6 | |
| F | GLY44 | |
| F | ARG48 | |
| F | THR139 | |
| A | THR139 | |
| F | ASN140 | |
| F | TYR145 | |
| F | ASP148 | |
| G | LYS6 | |
| G | GLY44 | |
| G | ARG48 | |
| G | THR139 | |
| G | ASN140 | |
| G | TYR145 | |
| G | ASP148 | |
| A | ASN140 | |
| H | LYS6 | |
| H | GLY44 | |
| H | ARG48 | |
| H | THR139 | |
| H | ASN140 | |
| H | TYR145 | |
| H | ASP148 | |
| I | LYS6 | |
| I | GLY44 | |
| I | ARG48 | |
| A | TYR145 | |
| I | THR139 | |
| I | ASN140 | |
| I | TYR145 | |
| I | ASP148 | |
| J | LYS6 | |
| J | GLY44 | |
| J | ARG48 | |
| J | THR139 | |
| J | ASN140 | |
| J | TYR145 | |
| A | ASP148 | |
| J | ASP148 | |
| K | LYS6 | |
| K | GLY44 | |
| K | ARG48 | |
| K | THR139 | |
| K | ASN140 | |
| K | TYR145 | |
| K | ASP148 | |
| L | LYS6 | |
| L | GLY44 | |
| B | LYS6 | |
| L | ARG48 | |
| L | THR139 | |
| L | ASN140 | |
| L | TYR145 | |
| L | ASP148 | |
| B | GLY44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17297917 |
| Chain | Residue | Details |
| A | GLY43 | |
| D | GLY43 | |
| D | ASP65 | |
| D | PHE113 | |
| E | GLY43 | |
| E | ASP65 | |
| E | PHE113 | |
| F | GLY43 | |
| F | ASP65 | |
| F | PHE113 | |
| G | GLY43 | |
| A | ASP65 | |
| G | ASP65 | |
| G | PHE113 | |
| H | GLY43 | |
| H | ASP65 | |
| H | PHE113 | |
| I | GLY43 | |
| I | ASP65 | |
| I | PHE113 | |
| J | GLY43 | |
| J | ASP65 | |
| A | PHE113 | |
| J | PHE113 | |
| K | GLY43 | |
| K | ASP65 | |
| K | PHE113 | |
| L | GLY43 | |
| L | ASP65 | |
| L | PHE113 | |
| B | GLY43 | |
| B | ASP65 | |
| B | PHE113 | |
| C | GLY43 | |
| C | ASP65 | |
| C | PHE113 |
