2J4K
Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP to 2.2 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006225 | biological_process | UDP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0033862 | molecular_function | UMP kinase activity |
| A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006225 | biological_process | UDP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0033862 | molecular_function | UMP kinase activity |
| B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006225 | biological_process | UDP biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0033862 | molecular_function | UMP kinase activity |
| C | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| C | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006225 | biological_process | UDP biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0033862 | molecular_function | UMP kinase activity |
| D | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| D | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0006225 | biological_process | UDP biosynthetic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0033862 | molecular_function | UMP kinase activity |
| E | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| E | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0006225 | biological_process | UDP biosynthetic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0033862 | molecular_function | UMP kinase activity |
| F | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
| F | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CD A 228 |
| Chain | Residue |
| A | TYR88 |
| A | HIS104 |
| C | TYR88 |
| C | HIS104 |
| F | TYR88 |
| F | HIS104 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 229 |
| Chain | Residue |
| A | HIS90 |
| A | HOH2020 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 230 |
| Chain | Residue |
| C | LYS147 |
| A | HIS160 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 231 |
| Chain | Residue |
| A | U5P227 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CD B 228 |
| Chain | Residue |
| B | TYR88 |
| B | HIS104 |
| D | TYR88 |
| D | HIS104 |
| D | HOH2021 |
| E | TYR88 |
| E | HIS104 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 229 |
| Chain | Residue |
| B | HIS90 |
| B | HOH2008 |
| B | HOH2020 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 230 |
| Chain | Residue |
| B | HIS160 |
| F | GLU29 |
| F | HOH2003 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 231 |
| Chain | Residue |
| B | GLU146 |
| B | HOH2036 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 232 |
| Chain | Residue |
| B | GLU224 |
| F | ASP212 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 233 |
| Chain | Residue |
| B | ASP18 |
| B | HOH2004 |
| B | HOH2005 |
| C | ASP18 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 234 |
| Chain | Residue |
| B | ASP15 |
| B | ASP18 |
| C | CD231 |
| C | HOH2001 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD C 228 |
| Chain | Residue |
| C | HIS90 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD C 229 |
| Chain | Residue |
| C | HIS160 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD C 231 |
| Chain | Residue |
| B | CD234 |
| C | ASP15 |
| C | ASP18 |
| C | HOH2001 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD D 228 |
| Chain | Residue |
| D | HIS90 |
| D | HOH2007 |
| D | HOH2024 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD E 228 |
| Chain | Residue |
| E | HIS90 |
| E | HOH2020 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD E 229 |
| Chain | Residue |
| E | HIS160 |
| F | ASP165 |
| F | HOH2037 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD F 228 |
| Chain | Residue |
| F | HIS90 |
| F | HOH2002 |
| F | HOH2017 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD F 229 |
| Chain | Residue |
| E | ASP165 |
| E | HOH2036 |
| F | HIS160 |
| F | HOH2035 |
| site_id | CC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE U5P A 227 |
| Chain | Residue |
| A | GLY42 |
| A | GLY43 |
| A | ASP65 |
| A | GLY68 |
| A | ILE69 |
| A | GLY112 |
| A | PHE113 |
| A | GLN114 |
| A | PRO115 |
| A | GLY116 |
| A | GLN117 |
| A | THR119 |
| A | VAL122 |
| A | MG231 |
| A | HOH2040 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE U5P B 227 |
| Chain | Residue |
| B | GLY43 |
| B | ASP65 |
| B | GLY68 |
| B | ILE69 |
| B | GLY112 |
| B | PHE113 |
| B | GLN114 |
| B | PRO115 |
| B | GLN117 |
| B | THR119 |
| B | VAL122 |
| B | HOH2003 |
| B | HOH2048 |
| B | HOH2049 |
| site_id | CC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE U5P C 227 |
| Chain | Residue |
| C | HOH2025 |
| C | GLY42 |
| C | GLY43 |
| C | ILE51 |
| C | ASP65 |
| C | GLY68 |
| C | ILE69 |
| C | GLY112 |
| C | PHE113 |
| C | GLN114 |
| C | PRO115 |
| C | GLN117 |
| C | THR119 |
| C | VAL122 |
| site_id | CC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE U5P D 227 |
| Chain | Residue |
| D | GLY42 |
| D | GLY43 |
| D | ASP65 |
| D | GLY68 |
| D | ILE69 |
| D | GLY112 |
| D | PHE113 |
| D | GLN114 |
| D | PRO115 |
| D | GLN117 |
| D | SER118 |
| D | THR119 |
| D | VAL122 |
| D | HOH2050 |
| D | HOH2051 |
| site_id | CC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE U5P E 227 |
| Chain | Residue |
| E | GLY42 |
| E | GLY43 |
| E | ASP65 |
| E | GLY68 |
| E | ILE69 |
| E | GLY112 |
| E | PHE113 |
| E | GLN114 |
| E | PRO115 |
| E | GLY116 |
| E | GLN117 |
| E | SER118 |
| E | THR119 |
| E | VAL122 |
| E | HOH2049 |
| E | HOH2050 |
| site_id | CC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE U5P F 227 |
| Chain | Residue |
| F | GLY42 |
| F | GLY43 |
| F | ASP65 |
| F | GLY68 |
| F | ILE69 |
| F | GLY112 |
| F | PHE113 |
| F | GLN114 |
| F | PRO115 |
| F | GLY116 |
| F | GLN117 |
| F | THR119 |
| F | VAL122 |
| F | HOH2007 |
| F | HOH2043 |
| F | HOH2044 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17297917","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
