Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2J4J

Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP and AMPPCP to 2.1 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0009041	molecular_function	UMP/dUMP kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0009041	molecular_function	UMP/dUMP kinase activity
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0009041	molecular_function	UMP/dUMP kinase activity
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006225	biological_process	UDP biosynthetic process
D	0009041	molecular_function	UMP/dUMP kinase activity
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0033862	molecular_function	UMP kinase activity
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006225	biological_process	UDP biosynthetic process
E	0009041	molecular_function	UMP/dUMP kinase activity
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016740	molecular_function	transferase activity
E	0033862	molecular_function	UMP kinase activity
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046940	biological_process	nucleoside monophosphate phosphorylation
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006225	biological_process	UDP biosynthetic process
F	0009041	molecular_function	UMP/dUMP kinase activity
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016740	molecular_function	transferase activity
F	0033862	molecular_function	UMP kinase activity
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 229

Chain	Residue
A	GLU182
A	U5P227
A	ACP228
A	HOH2069
A	HOH2070

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 230

Chain	Residue
E	TYR88
E	HIS104
A	TYR88
A	HIS104
C	TYR88
C	HIS104

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CO B 229

Chain	Residue
B	U5P227
B	ACP228

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO B 230

Chain	Residue
B	TYR88
B	HIS104
D	TYR88
D	HIS104
F	TYR88
F	HIS104

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO C 229

Chain	Residue
C	U5P227
C	ACP228
C	HOH2042

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 229

Chain	Residue
D	GLU182
D	U5P227
D	ACP228

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO E 229

Chain	Residue
E	GLU182
E	U5P227
E	ACP228

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 229

Chain	Residue
F	ARG48
F	THR180
F	TYR181
F	4TC227

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P A 227

Chain	Residue
A	GLY42
A	GLY43
A	ASP65
A	GLY68
A	ILE69
A	GLY112
A	PHE113
A	GLN114
A	PRO115
A	GLN117
A	SER118
A	THR119
A	VAL122
A	ACP228
A	CO229
A	HOH2001
A	HOH2065
A	HOH2070

site_id	BC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ACP A 228

Chain	Residue
A	LYS6
A	SER8
A	GLY9
A	LYS10
A	GLY43
A	GLY44
A	ARG48
A	THR139
A	ASN140
A	VAL141
A	GLY143
A	VAL144
A	TYR145
A	ASP148
A	PRO149
A	ILE169
A	GLU182
A	LEU183
A	U5P227
A	CO229
A	HOH2001
A	HOH2066
A	HOH2067
A	HOH2068
A	HOH2070

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE U5P B 227

Chain	Residue
B	GLY42
B	GLY43
B	ASP65
B	GLY68
B	ILE69
B	GLY112
B	PHE113
B	GLN114
B	PRO115
B	GLN117
B	SER118
B	THR119
B	VAL122
B	ACP228
B	CO229
B	HOH2066

site_id	BC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACP B 228

Chain	Residue
B	ASN140
B	GLY143
B	VAL144
B	TYR145
B	LYS147
B	ASP148
B	PRO149
B	ARG150
B	ILE169
B	GLU182
B	LEU183
B	U5P227
B	CO229
B	HOH2067
B	HOH2068
B	LYS6
B	SER8
B	GLY9
B	LYS10
B	GLY43
B	GLY44
B	ARG48
B	THR139

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE U5P C 227

Chain	Residue
C	GLY42
C	GLY43
C	ASP65
C	GLY68
C	ILE69
C	GLY112
C	PHE113
C	GLN114
C	PRO115
C	GLN117
C	THR119
C	VAL122
C	ACP228
C	CO229
C	HOH2037
C	HOH2038

site_id	BC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACP C 228

Chain	Residue
C	LYS6
C	SER8
C	GLY9
C	LYS10
C	GLY43
C	GLY44
C	ARG48
C	THR139
C	ASN140
C	GLY143
C	TYR145
C	LYS147
C	ASP148
C	PRO149
C	ARG150
C	ILE169
C	LEU170
C	LEU183
C	U5P227
C	CO229
C	HOH2039
C	HOH2040
C	HOH2041

site_id	BC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE U5P D 227

Chain	Residue
D	GLY42
D	GLY43
D	ASP65
D	GLY68
D	ILE69
D	GLY112
D	PHE113
D	GLN114
D	PRO115
D	GLN117
D	SER118
D	THR119
D	VAL122
D	ACP228
D	MG229
D	HOH2002
D	HOH2039

site_id	BC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ACP D 228

Chain	Residue
D	LYS6
D	SER8
D	GLY9
D	LYS10
D	GLY43
D	GLY44
D	ARG48
D	THR139
D	ASN140
D	GLY143
D	TYR145
D	LYS147
D	ASP148
D	PRO149
D	ARG150
D	ILE169
D	GLU182
D	LEU183
D	U5P227
D	MG229
D	HOH2002
D	HOH2040

site_id	BC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P E 227

Chain	Residue
E	GLY42
E	GLY43
E	ASP65
E	GLY68
E	ILE69
E	GLY112
E	PHE113
E	GLN114
E	PRO115
E	GLN117
E	SER118
E	THR119
E	VAL122
E	ACP228
E	CO229
E	HOH2002
E	HOH2045
E	HOH2046

site_id	BC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACP E 228

Chain	Residue
E	LYS6
E	SER8
E	GLY9
E	LYS10
E	GLY43
E	GLY44
E	ARG48
E	THR139
E	ASN140
E	GLY143
E	TYR145
E	LYS147
E	ASP148
E	PRO149
E	ARG150
E	GLU182
E	LEU183
E	U5P227
E	CO229
E	HOH2002
E	HOH2047

site_id	CC1
Number of Residues	40
Details	BINDING SITE FOR RESIDUE 4TC F 227

Chain	Residue
F	LYS6
F	SER8
F	GLY9
F	LYS10
F	GLY42
F	GLY43
F	GLY44
F	ARG48
F	ASP65
F	GLY68
F	ILE69
F	GLY112
F	PHE113
F	GLN114
F	PRO115
F	GLN117
F	SER118
F	THR119
F	VAL122
F	THR139
F	ASN140
F	VAL141
F	GLY143
F	VAL144
F	TYR145
F	LYS147
F	ASP148
F	PRO149
F	ARG150
F	ILE169
F	ALA178
F	GLY179
F	TYR181
F	GLU182
F	LEU183
F	MG229
F	HOH2052
F	HOH2068
F	HOH2069
F	HOH2070

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	BINDING:

Chain	Residue	Details
A	LYS6
B	ARG48
B	THR139
B	ASN140
B	TYR145
B	ASP148
C	LYS6
C	GLY44
C	ARG48
C	THR139
C	ASN140
A	GLY44
C	TYR145
C	ASP148
D	LYS6
D	GLY44
D	ARG48
D	THR139
D	ASN140
D	TYR145
D	ASP148
E	LYS6
A	ARG48
E	GLY44
E	ARG48
E	THR139
E	ASN140
E	TYR145
E	ASP148
F	LYS6
F	GLY44
F	ARG48
F	THR139
A	THR139
F	ASN140
F	TYR145
F	ASP148
A	ASN140
A	TYR145
A	ASP148
B	LYS6
B	GLY44

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:17297917

Chain	Residue	Details
A	GLY43
D	GLY43
D	ASP65
D	PHE113
E	GLY43
E	ASP65
E	PHE113
F	GLY43
F	ASP65
F	PHE113
A	ASP65
A	PHE113
B	GLY43
B	ASP65
B	PHE113
C	GLY43
C	ASP65
C	PHE113

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)