2J4J

Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP and AMPPCP to 2.1 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006225	biological_process	UDP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0033862	molecular_function	UMP kinase activity
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006225	biological_process	UDP biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0033862	molecular_function	UMP kinase activity
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046940	biological_process	nucleoside monophosphate phosphorylation
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006225	biological_process	UDP biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0033862	molecular_function	UMP kinase activity
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 229

Chain	Residue
A	GLU182
A	U5P227
A	ACP228
A	HOH2069
A	HOH2070

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 230

Chain	Residue
E	TYR88
E	HIS104
A	TYR88
A	HIS104
C	TYR88
C	HIS104

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CO B 229

Chain	Residue
B	U5P227
B	ACP228

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO B 230

Chain	Residue
B	TYR88
B	HIS104
D	TYR88
D	HIS104
F	TYR88
F	HIS104

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO C 229

Chain	Residue
C	U5P227
C	ACP228
C	HOH2042

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 229

Chain	Residue
D	GLU182
D	U5P227
D	ACP228

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO E 229

Chain	Residue
E	GLU182
E	U5P227
E	ACP228

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 229

Chain	Residue
F	ARG48
F	THR180
F	TYR181
F	4TC227

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P A 227

Chain	Residue
A	GLY42
A	GLY43
A	ASP65
A	GLY68
A	ILE69
A	GLY112
A	PHE113
A	GLN114
A	PRO115
A	GLN117
A	SER118
A	THR119
A	VAL122
A	ACP228
A	CO229
A	HOH2001
A	HOH2065
A	HOH2070

---

site_id	BC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ACP A 228

Chain	Residue
A	LYS6
A	SER8
A	GLY9
A	LYS10
A	GLY43
A	GLY44
A	ARG48
A	THR139
A	ASN140
A	VAL141
A	GLY143
A	VAL144
A	TYR145
A	ASP148
A	PRO149
A	ILE169
A	GLU182
A	LEU183
A	U5P227
A	CO229
A	HOH2001
A	HOH2066
A	HOH2067
A	HOH2068
A	HOH2070

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE U5P B 227

Chain	Residue
B	GLY42
B	GLY43
B	ASP65
B	GLY68
B	ILE69
B	GLY112
B	PHE113
B	GLN114
B	PRO115
B	GLN117
B	SER118
B	THR119
B	VAL122
B	ACP228
B	CO229
B	HOH2066

---

site_id	BC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACP B 228

Chain	Residue
B	ASN140
B	GLY143
B	VAL144
B	TYR145
B	LYS147
B	ASP148
B	PRO149
B	ARG150
B	ILE169
B	GLU182
B	LEU183
B	U5P227
B	CO229
B	HOH2067
B	HOH2068
B	LYS6
B	SER8
B	GLY9
B	LYS10
B	GLY43
B	GLY44
B	ARG48
B	THR139

---

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE U5P C 227

Chain	Residue
C	GLY42
C	GLY43
C	ASP65
C	GLY68
C	ILE69
C	GLY112
C	PHE113
C	GLN114
C	PRO115
C	GLN117
C	THR119
C	VAL122
C	ACP228
C	CO229
C	HOH2037
C	HOH2038

---

site_id	BC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACP C 228

Chain	Residue
C	LYS6
C	SER8
C	GLY9
C	LYS10
C	GLY43
C	GLY44
C	ARG48
C	THR139
C	ASN140
C	GLY143
C	TYR145
C	LYS147
C	ASP148
C	PRO149
C	ARG150
C	ILE169
C	LEU170
C	LEU183
C	U5P227
C	CO229
C	HOH2039
C	HOH2040
C	HOH2041

---

site_id	BC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE U5P D 227

Chain	Residue
D	GLY42
D	GLY43
D	ASP65
D	GLY68
D	ILE69
D	GLY112
D	PHE113
D	GLN114
D	PRO115
D	GLN117
D	SER118
D	THR119
D	VAL122
D	ACP228
D	MG229
D	HOH2002
D	HOH2039

---

site_id	BC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ACP D 228

Chain	Residue
D	LYS6
D	SER8
D	GLY9
D	LYS10
D	GLY43
D	GLY44
D	ARG48
D	THR139
D	ASN140
D	GLY143
D	TYR145
D	LYS147
D	ASP148
D	PRO149
D	ARG150
D	ILE169
D	GLU182
D	LEU183
D	U5P227
D	MG229
D	HOH2002
D	HOH2040

---

site_id	BC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE U5P E 227

Chain	Residue
E	GLY42
E	GLY43
E	ASP65
E	GLY68
E	ILE69
E	GLY112
E	PHE113
E	GLN114
E	PRO115
E	GLN117
E	SER118
E	THR119
E	VAL122
E	ACP228
E	CO229
E	HOH2002
E	HOH2045
E	HOH2046

---

site_id	BC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACP E 228

Chain	Residue
E	LYS6
E	SER8
E	GLY9
E	LYS10
E	GLY43
E	GLY44
E	ARG48
E	THR139
E	ASN140
E	GLY143
E	TYR145
E	LYS147
E	ASP148
E	PRO149
E	ARG150
E	GLU182
E	LEU183
E	U5P227
E	CO229
E	HOH2002
E	HOH2047

---

site_id	CC1
Number of Residues	40
Details	BINDING SITE FOR RESIDUE 4TC F 227

Chain	Residue
F	LYS6
F	SER8
F	GLY9
F	LYS10
F	GLY42
F	GLY43
F	GLY44
F	ARG48
F	ASP65
F	GLY68
F	ILE69
F	GLY112
F	PHE113
F	GLN114
F	PRO115
F	GLN117
F	SER118
F	THR119
F	VAL122
F	THR139
F	ASN140
F	VAL141
F	GLY143
F	VAL144
F	TYR145
F	LYS147
F	ASP148
F	PRO149
F	ARG150
F	ILE169
F	ALA178
F	GLY179
F	TYR181
F	GLU182
F	LEU183
F	MG229
F	HOH2052
F	HOH2068
F	HOH2069
F	HOH2070

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17297917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---