2J3S

Crystal structure of the human filamin A Ig domains 19 to 21

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0030036	biological_process	actin cytoskeleton organization
A	0051015	molecular_function	actin filament binding
B	0030036	biological_process	actin cytoskeleton organization
B	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A3330

Chain	Residue
A	GLY2244
A	GLY2245
A	PHE2259

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO A3331

Chain	Residue
A	ARG2146
A	ARG2148
A	GLY2269
A	GLY2270
A	LEU2271
A	PHE2311

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DIO A3332

Chain	Residue
A	GLU2258
A	SER2284
A	GLU2286
A	GLY2294
A	ALA2296

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B3330

Chain	Residue
A	GLY2234
B	THR2072

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO B3331

Chain	Residue
B	ARG2148
B	THR2263
B	GLY2269

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DIO B3332

Chain	Residue
B	SER2053
B	GLY2054

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	92
Details	Repeat: {"description":"Filamin 21"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25666618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26460884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8BTM8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---