2J3L
Prolyl-tRNA synthetase from Enterococcus faecalis complexed with a prolyl-adenylate analogue ('5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| A | 0140096 | molecular_function | catalytic activity, acting on a protein |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| B | 0140096 | molecular_function | catalytic activity, acting on a protein |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1566 |
| Chain | Residue |
| A | VAL272 |
| A | GLU273 |
| A | ARG276 |
| B | HIS246 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1567 |
| Chain | Residue |
| A | ARG151 |
| A | ASP219 |
| A | ARG447 |
| A | HOH2045 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A1568 |
| Chain | Residue |
| A | SER124 |
| A | ARG127 |
| A | ASN123 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1569 |
| Chain | Residue |
| A | THR88 |
| A | GLY203 |
| A | ARG417 |
| A | HOH2042 |
| A | HOH2083 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1570 |
| Chain | Residue |
| A | THR262 |
| A | ILE263 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1571 |
| Chain | Residue |
| A | LYS243 |
| A | ARG295 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1572 |
| Chain | Residue |
| A | LYS244 |
| A | HIS246 |
| A | GLU247 |
| B | SER245 |
| B | HIS246 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1573 |
| Chain | Residue |
| A | ARG193 |
| A | ALA194 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1574 |
| Chain | Residue |
| A | LYS205 |
| A | ASP420 |
| A | LYS434 |
| A | SER435 |
| A | HOH2071 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A1575 |
| Chain | Residue |
| A | ARG99 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1571 |
| Chain | Residue |
| B | THR262 |
| B | ILE263 |
| B | LYS279 |
| B | HOH2118 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1572 |
| Chain | Residue |
| A | LYS244 |
| A | HIS246 |
| B | VAL272 |
| B | GLU273 |
| B | ARG276 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1573 |
| Chain | Residue |
| B | ARG151 |
| B | GLU218 |
| B | ASP219 |
| B | ARG447 |
| B | HOH2119 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1574 |
| Chain | Residue |
| B | ILE122 |
| B | ASN123 |
| B | SER124 |
| B | ARG127 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1575 |
| Chain | Residue |
| B | THR88 |
| B | GLY203 |
| B | ARG417 |
| B | HOH2050 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1576 |
| Chain | Residue |
| A | ARG324 |
| B | ASP166 |
| B | GLU167 |
| B | LYS434 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1577 |
| Chain | Residue |
| B | ARG193 |
| B | ALA194 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1578 |
| Chain | Residue |
| B | GLU167 |
| B | LYS205 |
| B | GLY415 |
| B | THR416 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1579 |
| Chain | Residue |
| B | ARG48 |
| B | GLU502 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1580 |
| Chain | Residue |
| B | ARG144 |
| B | ARG151 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1581 |
| Chain | Residue |
| B | LYS243 |
| B | ARG295 |
| site_id | CC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE P5A A1576 |
| Chain | Residue |
| A | THR109 |
| A | GLU111 |
| A | ARG140 |
| A | GLU142 |
| A | GLY152 |
| A | PHE155 |
| A | MET157 |
| A | ASP159 |
| A | TYR161 |
| A | GLU407 |
| A | ILE408 |
| A | GLY409 |
| A | HIS410 |
| A | PHE412 |
| A | TYR441 |
| A | GLY442 |
| A | GLY444 |
| A | ARG447 |
| A | HOH2030 |
| A | HOH2084 |
| site_id | CC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE P5A B1582 |
| Chain | Residue |
| B | TYR161 |
| B | MET202 |
| B | GLU407 |
| B | ILE408 |
| B | GLY409 |
| B | HIS410 |
| B | PHE412 |
| B | TYR441 |
| B | GLY442 |
| B | GLY444 |
| B | ARG447 |
| B | HOH2044 |
| B | THR109 |
| B | GLU111 |
| B | ARG140 |
| B | GLU142 |
| B | GLY152 |
| B | PHE155 |
| B | MET157 |
| B | ASP159 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| A | ARG140 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| B | ARG140 |
