2J23

Cross-reactivity and crystal structure of Malassezia sympodialis Thioredoxin (Mala s 13), a member of a new pan-allergen family

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015035	molecular_function	protein-disulfide reductase activity
B	0015035	molecular_function	protein-disulfide reductase activity

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. VIdFWatWCGPCKmIgpvF

Chain	Residue	Details
A	VAL22-PHE40

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	208
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Contributes to redox potential value","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	GLY31
A	CYS30
A	PRO32
A	CYS33

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
B	GLY31
B	CYS30
B	PRO32
B	CYS33

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	CYS30
A	CYS33

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
B	CYS30
B	CYS33

---