2J23

Cross-reactivity and crystal structure of Malassezia sympodialis Thioredoxin (Mala s 13), a member of a new pan-allergen family

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015035	molecular_function	protein-disulfide reductase activity
B	0015035	molecular_function	protein-disulfide reductase activity

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. VIdFWatWCGPCKmIgpvF

Chain	Residue	Details
A	VAL22-PHE40

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P10599

Chain	Residue	Details
A	CYS30
A	CYS33
B	CYS30
B	CYS33

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Deprotonates C-terminal active site Cys => ECO:0000250|UniProtKB:P10599

Chain	Residue	Details
A	ASP24
B	ASP24

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Contributes to redox potential value => ECO:0000250|UniProtKB:P10599

Chain	Residue	Details
A	GLY31
A	PRO32
B	GLY31
B	PRO32

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	GLY31
A	CYS30
A	PRO32
A	CYS33

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
B	GLY31
B	CYS30
B	PRO32
B	CYS33

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	CYS30
A	CYS33

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
B	CYS30
B	CYS33

---