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2IZZ

Crystal structure of human pyrroline-5-carboxylate reductase

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0004735molecular_functionpyrroline-5-carboxylate reductase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006561biological_processproline biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0051881biological_processregulation of mitochondrial membrane potential
A0055129biological_processL-proline biosynthetic process
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B0004735molecular_functionpyrroline-5-carboxylate reductase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006561biological_processproline biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0051881biological_processregulation of mitochondrial membrane potential
B0055129biological_processL-proline biosynthetic process
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
C0004735molecular_functionpyrroline-5-carboxylate reductase activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0006561biological_processproline biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0051881biological_processregulation of mitochondrial membrane potential
C0055129biological_processL-proline biosynthetic process
C1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D0004735molecular_functionpyrroline-5-carboxylate reductase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0006561biological_processproline biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0051881biological_processregulation of mitochondrial membrane potential
D0055129biological_processL-proline biosynthetic process
D1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E0004735molecular_functionpyrroline-5-carboxylate reductase activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005759cellular_componentmitochondrial matrix
E0006561biological_processproline biosynthetic process
E0016491molecular_functionoxidoreductase activity
E0034599biological_processcellular response to oxidative stress
E0042802molecular_functionidentical protein binding
E0051881biological_processregulation of mitochondrial membrane potential
E0055129biological_processL-proline biosynthetic process
E1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
PDBデータベースに由来する情報
site_idAC1
残基数33
詳細BINDING SITE FOR RESIDUE NAD A 350
鎖名残基
AILE6
ALEU39
AASN56
AALA69
AVAL70
ALYS71
APRO72
AILE78
ACYS95
AALA96
AALA97
AGLY7
AMET121
ATHR122
ATHR124
AEDO1273
AHOH2026
AHOH2036
AHOH2146
AHOH2147
AHOH2148
AHOH2150
AALA8
AHOH2151
BASN230
BVAL231
BSER233
AGLY9
AGLN10
ALEU11
ASER33
ASER34
APRO35

site_idAC2
残基数5
詳細BINDING SITE FOR RESIDUE EDO A1272
鎖名残基
AVAL231
ATHR238
AHOH2152
BGLY175
BNAD350

site_idAC3
残基数5
詳細BINDING SITE FOR RESIDUE EDO A1273
鎖名残基
AGLY175
ANAD350
AHOH2153
BVAL231
BTHR238

site_idAC4
残基数6
詳細BINDING SITE FOR RESIDUE EDO A1274
鎖名残基
AASN230
ASER233
AHOH2113
AHOH2154
BLYS71
BNAD350

site_idAC5
残基数32
詳細BINDING SITE FOR RESIDUE NAD B 350
鎖名残基
AASN230
AVAL231
AEDO1272
AEDO1274
AHOH2117
BGLY7
BALA8
BGLY9
BGLN10
BLEU11
BSER34
BPRO35
BLEU39
BASN56
BALA69
BVAL70
BLYS71
BPRO72
BILE78
BCYS95
BALA96
BALA97
BMET121
BTHR122
BTHR124
BHOH2038
BHOH2161
BHOH2162
BHOH2163
BHOH2164
BHOH2165
BHOH2166

site_idAC6
残基数29
詳細BINDING SITE FOR RESIDUE NAD C 350
鎖名残基
CTHR124
CEDO1277
CHOH2121
CHOH2122
CHOH2123
CHOH2124
CHOH2125
CHOH2126
DASN230
DVAL231
DEDO1272
CILE6
CGLY7
CALA8
CGLY9
CGLN10
CLEU11
CSER34
CPRO35
CASN56
CALA69
CVAL70
CLYS71
CPRO72
CILE78
CCYS95
CALA96
CALA97
CTHR122

site_idAC7
残基数4
詳細BINDING SITE FOR RESIDUE EDO C1276
鎖名残基
CVAL231
CSER233
CTHR238
DNAD350

site_idAC8
残基数7
詳細BINDING SITE FOR RESIDUE EDO C1277
鎖名残基
CALA97
CTHR171
CGLY175
CNAD350
CHOH2127
DVAL231
DTHR238

site_idAC9
残基数26
詳細BINDING SITE FOR RESIDUE NAD D 350
鎖名残基
CASN230
CVAL231
CSER233
CEDO1276
DALA8
DGLY9
DGLN10
DLEU11
DSER33
DSER34
DPRO35
DLEU39
DASN56
DALA69
DVAL70
DLYS71
DPRO72
DCYS95
DALA96
DALA97
DTHR122
DTHR124
DHOH2122
DHOH2123
DHOH2125
DHOH2126

site_idBC1
残基数4
詳細BINDING SITE FOR RESIDUE EDO D1272
鎖名残基
CNAD350
DASN230
DSER233
DHOH2127

site_idBC2
残基数24
詳細BINDING SITE FOR RESIDUE NAD E 350
鎖名残基
EGLY7
EALA8
EGLY9
EGLN10
ELEU11
ESER34
EPRO35
ELEU39
EASN56
EALA69
EVAL70
ELYS71
EPRO72
ECYS95
EALA96
EALA97
ETHR122
ETHR124
EVAL231
EEDO1273
EHOH2117
EHOH2118
EHOH2119
EHOH2120

site_idBC3
残基数4
詳細BINDING SITE FOR RESIDUE EDO E1273
鎖名残基
ELYS71
EASN230
ESER233
ENAD350

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00521
残基数23
詳細P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE
鎖名残基詳細
APRO224-GLU246

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数25
詳細BINDING: BINDING => ECO:0000269|Ref.18
鎖名残基詳細
AILE6
BCYS95
CILE6
CSER34
CASN56
CALA69
CCYS95
DILE6
DSER34
DASN56
DALA69
ASER34
DCYS95
EILE6
ESER34
EASN56
EALA69
ECYS95
AASN56
AALA69
ACYS95
BILE6
BSER34
BASN56
BALA69

site_idSWS_FT_FI2
残基数5
詳細MOD_RES: N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330
鎖名残基詳細
ASER2
BSER2
CSER2
DSER2
ESER2

site_idSWS_FT_FI3
残基数5
詳細MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
鎖名残基詳細
ASER278
BSER278
CSER278
DSER278
ESER278

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件を2024-09-18に公開中

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