2IZZ
Crystal structure of human pyrroline-5-carboxylate reductase
GO(遺伝子オントロジー)由来の情報
鎖名 | GO(遺伝子オントロジー)id | 名前空間 | 内容 |
A | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006561 | biological_process | proline biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0042802 | molecular_function | identical protein binding |
A | 0051881 | biological_process | regulation of mitochondrial membrane potential |
A | 0055129 | biological_process | L-proline biosynthetic process |
A | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
B | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006561 | biological_process | proline biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0034599 | biological_process | cellular response to oxidative stress |
B | 0042802 | molecular_function | identical protein binding |
B | 0051881 | biological_process | regulation of mitochondrial membrane potential |
B | 0055129 | biological_process | L-proline biosynthetic process |
B | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
C | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0006561 | biological_process | proline biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0034599 | biological_process | cellular response to oxidative stress |
C | 0042802 | molecular_function | identical protein binding |
C | 0051881 | biological_process | regulation of mitochondrial membrane potential |
C | 0055129 | biological_process | L-proline biosynthetic process |
C | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
D | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0006561 | biological_process | proline biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0034599 | biological_process | cellular response to oxidative stress |
D | 0042802 | molecular_function | identical protein binding |
D | 0051881 | biological_process | regulation of mitochondrial membrane potential |
D | 0055129 | biological_process | L-proline biosynthetic process |
D | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
E | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0006561 | biological_process | proline biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0034599 | biological_process | cellular response to oxidative stress |
E | 0042802 | molecular_function | identical protein binding |
E | 0051881 | biological_process | regulation of mitochondrial membrane potential |
E | 0055129 | biological_process | L-proline biosynthetic process |
E | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
PDBデータベースに由来する情報
site_id | AC1 |
残基数 | 33 |
詳細 | BINDING SITE FOR RESIDUE NAD A 350 |
鎖名 | 残基 |
A | ILE6 |
A | LEU39 |
A | ASN56 |
A | ALA69 |
A | VAL70 |
A | LYS71 |
A | PRO72 |
A | ILE78 |
A | CYS95 |
A | ALA96 |
A | ALA97 |
A | GLY7 |
A | MET121 |
A | THR122 |
A | THR124 |
A | EDO1273 |
A | HOH2026 |
A | HOH2036 |
A | HOH2146 |
A | HOH2147 |
A | HOH2148 |
A | HOH2150 |
A | ALA8 |
A | HOH2151 |
B | ASN230 |
B | VAL231 |
B | SER233 |
A | GLY9 |
A | GLN10 |
A | LEU11 |
A | SER33 |
A | SER34 |
A | PRO35 |
site_id | AC2 |
残基数 | 5 |
詳細 | BINDING SITE FOR RESIDUE EDO A1272 |
鎖名 | 残基 |
A | VAL231 |
A | THR238 |
A | HOH2152 |
B | GLY175 |
B | NAD350 |
site_id | AC3 |
残基数 | 5 |
詳細 | BINDING SITE FOR RESIDUE EDO A1273 |
鎖名 | 残基 |
A | GLY175 |
A | NAD350 |
A | HOH2153 |
B | VAL231 |
B | THR238 |
site_id | AC4 |
残基数 | 6 |
詳細 | BINDING SITE FOR RESIDUE EDO A1274 |
鎖名 | 残基 |
A | ASN230 |
A | SER233 |
A | HOH2113 |
A | HOH2154 |
B | LYS71 |
B | NAD350 |
site_id | AC5 |
残基数 | 32 |
詳細 | BINDING SITE FOR RESIDUE NAD B 350 |
鎖名 | 残基 |
A | ASN230 |
A | VAL231 |
A | EDO1272 |
A | EDO1274 |
A | HOH2117 |
B | GLY7 |
B | ALA8 |
B | GLY9 |
B | GLN10 |
B | LEU11 |
B | SER34 |
B | PRO35 |
B | LEU39 |
B | ASN56 |
B | ALA69 |
B | VAL70 |
B | LYS71 |
B | PRO72 |
B | ILE78 |
B | CYS95 |
B | ALA96 |
B | ALA97 |
B | MET121 |
B | THR122 |
B | THR124 |
B | HOH2038 |
B | HOH2161 |
B | HOH2162 |
B | HOH2163 |
B | HOH2164 |
B | HOH2165 |
B | HOH2166 |
site_id | AC6 |
残基数 | 29 |
詳細 | BINDING SITE FOR RESIDUE NAD C 350 |
鎖名 | 残基 |
C | THR124 |
C | EDO1277 |
C | HOH2121 |
C | HOH2122 |
C | HOH2123 |
C | HOH2124 |
C | HOH2125 |
C | HOH2126 |
D | ASN230 |
D | VAL231 |
D | EDO1272 |
C | ILE6 |
C | GLY7 |
C | ALA8 |
C | GLY9 |
C | GLN10 |
C | LEU11 |
C | SER34 |
C | PRO35 |
C | ASN56 |
C | ALA69 |
C | VAL70 |
C | LYS71 |
C | PRO72 |
C | ILE78 |
C | CYS95 |
C | ALA96 |
C | ALA97 |
C | THR122 |
site_id | AC7 |
残基数 | 4 |
詳細 | BINDING SITE FOR RESIDUE EDO C1276 |
鎖名 | 残基 |
C | VAL231 |
C | SER233 |
C | THR238 |
D | NAD350 |
site_id | AC8 |
残基数 | 7 |
詳細 | BINDING SITE FOR RESIDUE EDO C1277 |
鎖名 | 残基 |
C | ALA97 |
C | THR171 |
C | GLY175 |
C | NAD350 |
C | HOH2127 |
D | VAL231 |
D | THR238 |
site_id | AC9 |
残基数 | 26 |
詳細 | BINDING SITE FOR RESIDUE NAD D 350 |
鎖名 | 残基 |
C | ASN230 |
C | VAL231 |
C | SER233 |
C | EDO1276 |
D | ALA8 |
D | GLY9 |
D | GLN10 |
D | LEU11 |
D | SER33 |
D | SER34 |
D | PRO35 |
D | LEU39 |
D | ASN56 |
D | ALA69 |
D | VAL70 |
D | LYS71 |
D | PRO72 |
D | CYS95 |
D | ALA96 |
D | ALA97 |
D | THR122 |
D | THR124 |
D | HOH2122 |
D | HOH2123 |
D | HOH2125 |
D | HOH2126 |
site_id | BC1 |
残基数 | 4 |
詳細 | BINDING SITE FOR RESIDUE EDO D1272 |
鎖名 | 残基 |
C | NAD350 |
D | ASN230 |
D | SER233 |
D | HOH2127 |
site_id | BC2 |
残基数 | 24 |
詳細 | BINDING SITE FOR RESIDUE NAD E 350 |
鎖名 | 残基 |
E | GLY7 |
E | ALA8 |
E | GLY9 |
E | GLN10 |
E | LEU11 |
E | SER34 |
E | PRO35 |
E | LEU39 |
E | ASN56 |
E | ALA69 |
E | VAL70 |
E | LYS71 |
E | PRO72 |
E | CYS95 |
E | ALA96 |
E | ALA97 |
E | THR122 |
E | THR124 |
E | VAL231 |
E | EDO1273 |
E | HOH2117 |
E | HOH2118 |
E | HOH2119 |
E | HOH2120 |
site_id | BC3 |
残基数 | 4 |
詳細 | BINDING SITE FOR RESIDUE EDO E1273 |
鎖名 | 残基 |
E | LYS71 |
E | ASN230 |
E | SER233 |
E | NAD350 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_id | PS00521 |
残基数 | 23 |
詳細 | P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE |
鎖名 | 残基 | 詳細 |
A | PRO224-GLU246 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
site_id | SWS_FT_FI1 |
残基数 | 25 |
詳細 | BINDING: BINDING => ECO:0000269|Ref.18 |
鎖名 | 残基 | 詳細 |
A | ILE6 | |
B | CYS95 | |
C | ILE6 | |
C | SER34 | |
C | ASN56 | |
C | ALA69 | |
C | CYS95 | |
D | ILE6 | |
D | SER34 | |
D | ASN56 | |
D | ALA69 | |
A | SER34 | |
D | CYS95 | |
E | ILE6 | |
E | SER34 | |
E | ASN56 | |
E | ALA69 | |
E | CYS95 | |
A | ASN56 | |
A | ALA69 | |
A | CYS95 | |
B | ILE6 | |
B | SER34 | |
B | ASN56 | |
B | ALA69 |
site_id | SWS_FT_FI2 |
残基数 | 5 |
詳細 | MOD_RES: N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 |
鎖名 | 残基 | 詳細 |
A | SER2 | |
B | SER2 | |
C | SER2 | |
D | SER2 | |
E | SER2 |
site_id | SWS_FT_FI3 |
残基数 | 5 |
詳細 | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
鎖名 | 残基 | 詳細 |
A | SER278 | |
B | SER278 | |
C | SER278 | |
D | SER278 | |
E | SER278 |