2IYY

Shikimate kinase from Mycobacterium tuberculosis in complex with shikimate-3-phosphate and SO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004765	molecular_function	shikimate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019632	biological_process	shikimate metabolic process
A	0019752	biological_process	carboxylic acid metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	LEU10
A	HOH2229
A	HOH2230
A	HOH2231
A	HOH2232
A	HOH2233
A	PRO11
A	GLY12
A	SER13
A	GLY14
A	LYS15
A	SER16
A	PO4204
A	HOH2020

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 204

Chain	Residue
A	PRO11
A	LYS15
A	ASP34
A	GLY80
A	S3P201
A	SO4202
A	HOH2233
A	HOH2234
A	HOH2235

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 205

Chain	Residue
A	THR17
A	ARG21
A	PRO155
A	MG213
A	HOH2236

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 206

Chain	Residue
A	ARG66
A	ALA90
A	ALA91
A	PRO123
A	ASP124
A	ARG125
A	HOH2140
A	HOH2142
A	HOH2174
A	HOH2237

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 207

Chain	Residue
A	ARG89
A	ARG142
A	HOH2238
A	HOH2239

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 208

Chain	Residue
A	ARG109
A	ARG153
A	ARG160
A	HIS161

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 209

Chain	Residue
A	ARG109
A	ARG110
A	ARG153
A	ASN154
A	ALA157
A	ARG160
A	HOH2208

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 210

Chain	Residue
A	ALA126
A	GLU127
A	ARG130
A	HOH2176
A	HOH2241
A	HOH2242

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 211

Chain	Residue
A	GLU38
A	SER44
A	ILE45
A	HOH2088
A	HOH2224

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 212

Chain	Residue
A	GLU56
A	ARG130
A	MET133
A	ALA134

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 213

Chain	Residue
A	ARG20
A	SO4205
A	HOH2236

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 214

Chain	Residue
A	ARG58
A	GLU61
A	GLU62
A	SER85

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 215

Chain	Residue
A	ARG20
A	LYS24
A	HOH2012
A	HOH2049

---

site_id	BC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE S3P A 201

Chain	Residue
A	PRO11
A	LYS15
A	ASP34
A	ARG58
A	GLY79
A	GLY80
A	GLY81
A	PRO118
A	LEU119
A	ARG136
A	PO4204
A	HOH2225
A	HOH2226
A	HOH2227
A	HOH2228
A	HOH2229
A	HOH2233
A	HOH2234
A	HOH2235

---

Functional Information from PROSITE/UniProt

site_id	PS01128
Number of Residues	26
Details	SHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV

Chain	Residue	Details
A	ARG58-VAL83

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"LID domain"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

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