2IYX

Shikimate kinase from Mycobacterium tuberculosis in complex with shikimate and SO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004765	molecular_function	shikimate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019632	biological_process	shikimate metabolic process
A	0019752	biological_process	carboxylic acid metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	LEU10
A	HOH2275
A	HOH2277
A	HOH2278
A	PRO11
A	GLY12
A	SER13
A	GLY14
A	LYS15
A	SER16
A	HOH2273
A	HOH2274

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	THR17
A	ARG21
A	PRO155
A	MG211
A	HOH2279

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 204

Chain	Residue
A	ARG66
A	ALA90
A	ALA91
A	PRO123
A	ASP124
A	ARG125
A	HOH2163
A	HOH2165
A	HOH2205
A	HOH2280

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 205

Chain	Residue
A	ARG89
A	ARG142
A	HOH2281
A	HOH2282
A	HOH2284

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 206

Chain	Residue
A	ARG109
A	ARG153
A	ALA157
A	ARG160
A	HIS161

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 207

Chain	Residue
A	ARG109
A	ARG110
A	ARG153
A	ASN154
A	ALA157
A	HOH2246
A	HOH2285

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 208

Chain	Residue
A	GLU127
A	ARG130
A	HOH2207
A	HOH2286
A	HOH2287

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 209

Chain	Residue
A	GLU38
A	ILE45
A	HOH2105
A	HOH2267

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 210

Chain	Residue
A	GLU56
A	ARG130
A	MET133
A	HOH2130

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 211

Chain	Residue
A	ARG20
A	SO4203
A	HOH2279

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 212

Chain	Residue
A	ARG58
A	GLU61
A	GLU62
A	SER85

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 213

Chain	Residue
A	ARG20
A	LYS24
A	HOH2013
A	HOH2060

---

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SKM A 201

Chain	Residue
A	ASP34
A	ARG58
A	GLY80
A	GLY81
A	LEU119
A	ARG136
A	HOH2020
A	HOH2139
A	HOH2197
A	HOH2269
A	HOH2271
A	HOH2272

---

Functional Information from PROSITE/UniProt

site_id	PS01128
Number of Residues	26
Details	SHIKIMATE_KINASE Shikimate kinase signature. RriEedvVraaladhdg...VLSlGGGaV

Chain	Residue	Details
A	ARG58-VAL83

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"LID domain"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

---