2IXJ

RmlC P aeruginosa native

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
A	0045226	biological_process	extracellular polysaccharide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SRT A1185

Chain	Residue
A	ARG62
A	HOH2067
A	HOH2085
A	HOH2086
A	HOH2087
A	HIS65
A	LYS74
A	ARG92
A	HIS121
A	TYR134
A	TRP140
A	GLU145
A	HOH2029

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17046787

Chain	Residue	Details
A	HIS65

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:17046787

Chain	Residue	Details
A	TYR134

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXK

Chain	Residue	Details
A	ARG26
A	GLU31

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:17046787, ECO:0007744|PDB:2IXH

Chain	Residue	Details
A	GLN50

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK

Chain	Residue	Details
A	ARG62

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site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK

Chain	Residue	Details
A	LYS74
A	HIS121

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXJ

Chain	Residue	Details
A	GLU145

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site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXK

Chain	Residue	Details
A	LYS170

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site_id	SWS_FT_FI9
Number of Residues	1
Details	SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000250|UniProtKB:Q5SFD1

Chain	Residue	Details
A	TRP140

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
A	HIS65
A	ASP171

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 329

Chain	Residue	Details
A	HIS65	proton acceptor, proton donor
A	LYS74	electrostatic stabiliser
A	TYR134	proton acceptor, proton donor, proton relay
A	ASP171	electrostatic stabiliser, increase acidity, increase basicity

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