2IXH
RmlC P aeruginosa with dTDP-rhamnose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| A | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TRH A1185 |
| Chain | Residue |
| A | PHE22 |
| A | TYR134 |
| A | TRP140 |
| A | LYS170 |
| A | HOH2229 |
| A | HOH2253 |
| A | HOH2281 |
| A | HOH2282 |
| A | HOH2283 |
| A | HOH2284 |
| A | HOH2285 |
| A | ARG26 |
| A | HOH2286 |
| A | HOH2287 |
| A | HOH2288 |
| A | PHE29 |
| A | GLU31 |
| A | GLN50 |
| A | ARG62 |
| A | HIS65 |
| A | LYS74 |
| A | HIS121 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TRH B1185 |
| Chain | Residue |
| B | PHE22 |
| B | ARG26 |
| B | PHE29 |
| B | GLU31 |
| B | GLN50 |
| B | ARG62 |
| B | HIS65 |
| B | LYS74 |
| B | HIS121 |
| B | TYR134 |
| B | TRP140 |
| B | LYS170 |
| B | HOH2272 |
| B | HOH2293 |
| B | HOH2294 |
| B | HOH2295 |
| B | HOH2296 |
| B | HOH2297 |
| B | HOH2298 |
| B | HOH2299 |
| B | HOH2300 |
| B | HOH2301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17046787 |
| Chain | Residue | Details |
| A | HIS65 | |
| B | HIS65 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17046787 |
| Chain | Residue | Details |
| A | TYR134 | |
| B | TYR134 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | ARG26 | |
| A | GLU31 | |
| B | ARG26 | |
| B | GLU31 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17046787, ECO:0007744|PDB:2IXH |
| Chain | Residue | Details |
| A | GLN50 | |
| B | GLN50 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | ARG62 | |
| B | ARG62 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | LYS74 | |
| A | HIS121 | |
| B | LYS74 | |
| B | HIS121 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXJ |
| Chain | Residue | Details |
| A | GLU145 | |
| B | GLU145 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | LYS170 | |
| B | LYS170 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000250|UniProtKB:Q5SFD1 |
| Chain | Residue | Details |
| A | TRP140 | |
| B | TRP140 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 329 |
| Chain | Residue | Details |
| A | HIS65 | proton acceptor, proton donor |
| A | LYS74 | electrostatic stabiliser |
| A | TYR134 | proton acceptor, proton donor, proton relay |
| A | ASP171 | electrostatic stabiliser, increase acidity, increase basicity |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 329 |
| Chain | Residue | Details |
| B | HIS65 | proton acceptor, proton donor |
| B | LYS74 | electrostatic stabiliser |
| B | TYR134 | proton acceptor, proton donor, proton relay |
| B | ASP171 | electrostatic stabiliser, increase acidity, increase basicity |
