2IXH

RmlC P aeruginosa with dTDP-rhamnose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000271	biological_process	polysaccharide biosynthetic process
A	0005829	cellular_component	cytosol
A	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
B	0000271	biological_process	polysaccharide biosynthetic process
B	0005829	cellular_component	cytosol
B	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0016853	molecular_function	isomerase activity
B	0019305	biological_process	dTDP-rhamnose biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TRH A1185

Chain	Residue
A	PHE22
A	TYR134
A	TRP140
A	LYS170
A	HOH2229
A	HOH2253
A	HOH2281
A	HOH2282
A	HOH2283
A	HOH2284
A	HOH2285
A	ARG26
A	HOH2286
A	HOH2287
A	HOH2288
A	PHE29
A	GLU31
A	GLN50
A	ARG62
A	HIS65
A	LYS74
A	HIS121

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TRH B1185

Chain	Residue
B	PHE22
B	ARG26
B	PHE29
B	GLU31
B	GLN50
B	ARG62
B	HIS65
B	LYS74
B	HIS121
B	TYR134
B	TRP140
B	LYS170
B	HOH2272
B	HOH2293
B	HOH2294
B	HOH2295
B	HOH2296
B	HOH2297
B	HOH2298
B	HOH2299
B	HOH2300
B	HOH2301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose","evidences":[{"source":"UniProtKB","id":"Q5SFD1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
A	HIS65
A	ASP171

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
B	HIS65
B	ASP171

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 329

Chain	Residue	Details
A	HIS65	proton acceptor, proton donor
A	LYS74	electrostatic stabiliser
A	TYR134	proton acceptor, proton donor, proton relay
A	ASP171	electrostatic stabiliser, increase acidity, increase basicity

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 329

Chain	Residue	Details
B	HIS65	proton acceptor, proton donor
B	LYS74	electrostatic stabiliser
B	TYR134	proton acceptor, proton donor, proton relay
B	ASP171	electrostatic stabiliser, increase acidity, increase basicity

---