2IXC
RmlC M. tuberculosis with dTDP-rhamnose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| A | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| C | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| D | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TRH A1199 |
| Chain | Residue |
| A | GLN47 |
| A | HOH2218 |
| A | HOH2251 |
| A | HOH2252 |
| A | HOH2253 |
| A | HOH2254 |
| A | HOH2255 |
| A | HOH2256 |
| A | HOH2257 |
| B | HIS19 |
| B | ARG23 |
| A | ASN49 |
| B | PHE26 |
| B | GLU28 |
| C | GLU90 |
| C | ARG181 |
| A | ARG59 |
| A | HIS62 |
| A | LYS72 |
| A | HIS119 |
| A | TYR132 |
| A | TYR138 |
| A | ARG170 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE TRH B1199 |
| Chain | Residue |
| A | PHE26 |
| A | GLU28 |
| B | GLN47 |
| B | ASN49 |
| B | ARG59 |
| B | HIS62 |
| B | LYS72 |
| B | HIS119 |
| B | TYR132 |
| B | TYR138 |
| B | GLU143 |
| B | ARG170 |
| B | ASP171 |
| B | HOH2068 |
| B | HOH2220 |
| B | HOH2294 |
| B | HOH2295 |
| B | HOH2296 |
| B | HOH2297 |
| B | HOH2298 |
| B | HOH2299 |
| B | HOH2300 |
| B | HOH2301 |
| B | HOH2302 |
| B | HOH2303 |
| B | HOH2304 |
| D | GLU90 |
| D | ARG181 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE TRH C1199 |
| Chain | Residue |
| A | GLU90 |
| A | ARG181 |
| C | GLN47 |
| C | ASN49 |
| C | ARG59 |
| C | HIS62 |
| C | LYS72 |
| C | HIS119 |
| C | TYR132 |
| C | TYR138 |
| C | ARG170 |
| C | HOH2213 |
| C | HOH2317 |
| C | HOH2318 |
| C | HOH2319 |
| C | HOH2320 |
| C | HOH2321 |
| C | HOH2322 |
| C | HOH2323 |
| C | HOH2324 |
| C | HOH2326 |
| C | HOH2327 |
| D | PHE26 |
| D | GLU28 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE TRH D1199 |
| Chain | Residue |
| D | HOH2274 |
| B | GLU90 |
| B | ARG181 |
| C | HIS19 |
| C | ARG23 |
| C | PHE26 |
| C | GLU28 |
| D | GLN47 |
| D | ASN49 |
| D | ARG59 |
| D | HIS62 |
| D | LYS72 |
| D | HIS119 |
| D | TYR132 |
| D | TYR138 |
| D | ARG170 |
| D | HOH2265 |
| D | HOH2266 |
| D | HOH2267 |
| D | HOH2268 |
| D | HOH2269 |
| D | HOH2270 |
| D | HOH2271 |
| D | HOH2272 |
| D | HOH2273 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17046787, ECO:0007744|PDB:2IXC |
| Chain | Residue | Details |
| A | HIS62 | |
| B | HIS62 | |
| C | HIS62 | |
| D | HIS62 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q9HU21 |
| Chain | Residue | Details |
| A | TYR132 | |
| B | TYR132 | |
| C | TYR132 | |
| D | TYR132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXC |
| Chain | Residue | Details |
| A | ARG23 | |
| D | ARG23 | |
| D | GLU28 | |
| D | ARG59 | |
| A | GLU28 | |
| A | ARG59 | |
| B | ARG23 | |
| B | GLU28 | |
| B | ARG59 | |
| C | ARG23 | |
| C | GLU28 | |
| C | ARG59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17046787, ECO:0007744|PDB:2IXC |
| Chain | Residue | Details |
| A | GLN47 | |
| B | GLN47 | |
| C | GLN47 | |
| D | GLN47 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000305|PubMed:12951098, ECO:0007744|PDB:1PM7 |
| Chain | Residue | Details |
| A | LYS72 | |
| B | LYS72 | |
| C | LYS72 | |
| D | LYS72 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000305|PubMed:12951098, ECO:0007744|PDB:1PM7, ECO:0007744|PDB:2IXC |
| Chain | Residue | Details |
| A | HIS119 | |
| B | HIS119 | |
| C | HIS119 | |
| D | HIS119 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9HU21 |
| Chain | Residue | Details |
| A | GLU143 | |
| A | ARG170 | |
| B | GLU143 | |
| B | ARG170 | |
| C | GLU143 | |
| C | ARG170 | |
| D | GLU143 | |
| D | ARG170 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000250|UniProtKB:Q5SFD1 |
| Chain | Residue | Details |
| A | TYR138 | |
| B | TYR138 | |
| C | TYR138 | |
| D | TYR138 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| A | HIS62 | |
| A | ASP171 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| B | HIS62 | |
| B | ASP171 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| C | HIS62 | |
| C | ASP171 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| D | HIS62 | |
| D | ASP171 |
