2IXC

RmlC M. tuberculosis with dTDP-rhamnose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000271	biological_process	polysaccharide biosynthetic process
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A	0016853	molecular_function	isomerase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
B	0000271	biological_process	polysaccharide biosynthetic process
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B	0016853	molecular_function	isomerase activity
B	0019305	biological_process	dTDP-rhamnose biosynthetic process
C	0000271	biological_process	polysaccharide biosynthetic process
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C	0016853	molecular_function	isomerase activity
C	0019305	biological_process	dTDP-rhamnose biosynthetic process
D	0000271	biological_process	polysaccharide biosynthetic process
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D	0016853	molecular_function	isomerase activity
D	0019305	biological_process	dTDP-rhamnose biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE TRH A1199

Chain	Residue
A	GLN47
A	HOH2218
A	HOH2251
A	HOH2252
A	HOH2253
A	HOH2254
A	HOH2255
A	HOH2256
A	HOH2257
B	HIS19
B	ARG23
A	ASN49
B	PHE26
B	GLU28
C	GLU90
C	ARG181
A	ARG59
A	HIS62
A	LYS72
A	HIS119
A	TYR132
A	TYR138
A	ARG170

---

site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE TRH B1199

Chain	Residue
A	PHE26
A	GLU28
B	GLN47
B	ASN49
B	ARG59
B	HIS62
B	LYS72
B	HIS119
B	TYR132
B	TYR138
B	GLU143
B	ARG170
B	ASP171
B	HOH2068
B	HOH2220
B	HOH2294
B	HOH2295
B	HOH2296
B	HOH2297
B	HOH2298
B	HOH2299
B	HOH2300
B	HOH2301
B	HOH2302
B	HOH2303
B	HOH2304
D	GLU90
D	ARG181

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE TRH C1199

Chain	Residue
A	GLU90
A	ARG181
C	GLN47
C	ASN49
C	ARG59
C	HIS62
C	LYS72
C	HIS119
C	TYR132
C	TYR138
C	ARG170
C	HOH2213
C	HOH2317
C	HOH2318
C	HOH2319
C	HOH2320
C	HOH2321
C	HOH2322
C	HOH2323
C	HOH2324
C	HOH2326
C	HOH2327
D	PHE26
D	GLU28

---

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE TRH D1199

Chain	Residue
D	HOH2274
B	GLU90
B	ARG181
C	HIS19
C	ARG23
C	PHE26
C	GLU28
D	GLN47
D	ASN49
D	ARG59
D	HIS62
D	LYS72
D	HIS119
D	TYR132
D	TYR138
D	ARG170
D	HOH2265
D	HOH2266
D	HOH2267
D	HOH2268
D	HOH2269
D	HOH2270
D	HOH2271
D	HOH2272
D	HOH2273

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2IXC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q9HU21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IXC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2IXC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12951098","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1PM7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12951098","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1PM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9HU21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose","evidences":[{"source":"UniProtKB","id":"Q5SFD1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
A	HIS62
A	ASP171

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
B	HIS62
B	ASP171

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
C	HIS62
C	ASP171

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
D	HIS62
D	ASP171

---