2IWZ
Human mitochondrial beta-ketoacyl ACP synthase complexed with hexanoic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0051790 | biological_process | short-chain fatty acid biosynthetic process |
| A | 0051792 | biological_process | medium-chain fatty acid biosynthetic process |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0051790 | biological_process | short-chain fatty acid biosynthetic process |
| B | 0051792 | biological_process | medium-chain fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NH4 A1461 |
| Chain | Residue |
| A | ASN346 |
| A | ALA347 |
| A | GLU394 |
| A | THR442 |
| A | ASN443 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NH4 B1461 |
| Chain | Residue |
| B | ASN443 |
| B | ASN346 |
| B | ALA347 |
| B | GLU394 |
| B | THR442 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 6NA A1460 |
| Chain | Residue |
| A | GLY153 |
| A | ALA208 |
| A | CYS209 |
| A | PHE248 |
| A | GLY446 |
| A | PHE447 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 6NA B1460 |
| Chain | Residue |
| B | GLY153 |
| B | ALA208 |
| B | CYS209 |
| B | ASP237 |
| B | PHE248 |
| B | GLY446 |
| B | PHE447 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGYGLSGDAGhItapdpegegalrcma...AALK |
| Chain | Residue | Details |
| A | LEU303-LYS333 |
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPNhaVStACTTGahAV |
| Chain | Residue | Details |
| A | GLY200-VAL216 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | CYS209 | |
| A | HIS348 | |
| A | HIS385 | |
| B | CYS209 | |
| B | HIS348 | |
| B | HIS385 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D404 |
| Chain | Residue | Details |
| A | LYS109 | |
| A | LYS174 | |
| B | LYS109 | |
| B | LYS174 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9D404 |
| Chain | Residue | Details |
| A | LYS113 | |
| B | LYS113 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | HIS348 | |
| A | CYS209 | |
| A | PHE447 | |
| A | HIS385 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | HIS348 | |
| B | CYS209 | |
| B | PHE447 | |
| B | HIS385 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | HIS348 | |
| A | PHE445 | |
| A | CYS209 | |
| A | PHE447 | |
| A | HIS385 | |
| A | LYS380 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | HIS348 | |
| B | PHE445 | |
| B | CYS209 | |
| B | PHE447 | |
| B | HIS385 | |
| B | LYS380 |
