2IWI
CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007346 | biological_process | regulation of mitotic cell cycle |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0009615 | biological_process | response to virus |
| A | 0010508 | biological_process | positive regulation of autophagy |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0050821 | biological_process | protein stabilization |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006915 | biological_process | apoptotic process |
| B | 0007346 | biological_process | regulation of mitotic cell cycle |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0009615 | biological_process | response to virus |
| B | 0010508 | biological_process | positive regulation of autophagy |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0050821 | biological_process | protein stabilization |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HB1 A 1289 |
| Chain | Residue |
| A | GLY39 |
| A | LEU170 |
| A | ILE181 |
| A | ASP182 |
| A | PHE43 |
| A | VAL46 |
| A | ILE100 |
| A | LEU116 |
| A | GLU117 |
| A | ARG118 |
| A | ASP124 |
| A | GLU167 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HB1 B 1288 |
| Chain | Residue |
| B | GLY39 |
| B | PHE43 |
| B | VAL46 |
| B | LEU116 |
| B | GLU117 |
| B | ARG118 |
| B | GLU167 |
| B | LEU170 |
| B | ILE181 |
| B | ASP182 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGTVFaGhrltdrlq..........VAIK |
| Chain | Residue | Details |
| A | LEU38-LYS61 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDIKdeNILI |
| Chain | Residue | Details |
| A | VAL159-ILE171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | GLU167 | |
| A | ASP163 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | GLU167 | |
| B | ASP163 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS165 | |
| A | ASP163 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS165 | |
| B | ASP163 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | THR200 | |
| A | LYS165 | |
| A | ASP163 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | THR200 | |
| B | LYS165 | |
| B | ASP163 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS165 | |
| A | ASN168 | |
| A | ASP163 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS165 | |
| B | ASN168 | |
| B | ASP163 |
