2IWI
CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006915 | biological_process | apoptotic process |
A | 0007346 | biological_process | regulation of mitotic cell cycle |
A | 0008285 | biological_process | negative regulation of cell population proliferation |
A | 0008637 | biological_process | apoptotic mitochondrial changes |
A | 0009615 | biological_process | response to virus |
A | 0010508 | biological_process | positive regulation of autophagy |
A | 0016236 | biological_process | macroautophagy |
A | 0016239 | biological_process | positive regulation of macroautophagy |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
A | 0050821 | biological_process | protein stabilization |
A | 0106310 | molecular_function | protein serine kinase activity |
B | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006468 | biological_process | protein phosphorylation |
B | 0006915 | biological_process | apoptotic process |
B | 0007346 | biological_process | regulation of mitotic cell cycle |
B | 0008285 | biological_process | negative regulation of cell population proliferation |
B | 0008637 | biological_process | apoptotic mitochondrial changes |
B | 0009615 | biological_process | response to virus |
B | 0010508 | biological_process | positive regulation of autophagy |
B | 0016236 | biological_process | macroautophagy |
B | 0016239 | biological_process | positive regulation of macroautophagy |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
B | 0050821 | biological_process | protein stabilization |
B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE HB1 A 1289 |
Chain | Residue |
A | GLY39 |
A | LEU170 |
A | ILE181 |
A | ASP182 |
A | PHE43 |
A | VAL46 |
A | ILE100 |
A | LEU116 |
A | GLU117 |
A | ARG118 |
A | ASP124 |
A | GLU167 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE HB1 B 1288 |
Chain | Residue |
B | GLY39 |
B | PHE43 |
B | VAL46 |
B | LEU116 |
B | GLU117 |
B | ARG118 |
B | GLU167 |
B | LEU170 |
B | ILE181 |
B | ASP182 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGTVFaGhrltdrlq..........VAIK |
Chain | Residue | Details |
A | LEU38-LYS61 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDIKdeNILI |
Chain | Residue | Details |
A | VAL159-ILE171 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP163 | |
B | ASP163 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU38 | |
A | LYS61 | |
B | LEU38 | |
B | LYS61 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | GLU167 | |
A | ASP163 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | GLU167 | |
B | ASP163 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS165 | |
A | ASP163 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS165 | |
B | ASP163 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | THR200 | |
A | LYS165 | |
A | ASP163 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | THR200 | |
B | LYS165 | |
B | ASP163 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS165 | |
A | ASN168 | |
A | ASP163 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS165 | |
B | ASN168 | |
B | ASP163 |