2IWH
Structure of yeast Elongation Factor 3 in complex with ADPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002182 | biological_process | cytoplasmic translational elongation |
| A | 0002184 | biological_process | cytoplasmic translational termination |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005840 | cellular_component | ribosome |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0006415 | biological_process | translational termination |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019843 | molecular_function | rRNA binding |
| A | 0022626 | cellular_component | cytosolic ribosome |
| A | 0043022 | molecular_function | ribosome binding |
| B | 0002182 | biological_process | cytoplasmic translational elongation |
| B | 0002184 | biological_process | cytoplasmic translational termination |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005840 | cellular_component | ribosome |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0006415 | biological_process | translational termination |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0019843 | molecular_function | rRNA binding |
| B | 0022626 | cellular_component | cytosolic ribosome |
| B | 0043022 | molecular_function | ribosome binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A2974 |
| Chain | Residue |
| A | SER544 |
| A | TRP547 |
| A | ASN577 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A2975 |
| Chain | Residue |
| A | LYS447 |
| A | GLN449 |
| A | LYS616 |
| A | ARG618 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A2976 |
| Chain | Residue |
| A | ASN586 |
| B | ARG871 |
| A | VAL582 |
| A | ASN583 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A2977 |
| Chain | Residue |
| A | ASN464 |
| A | GLY465 |
| A | CYS466 |
| A | GLY467 |
| A | LYS468 |
| A | SER469 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A2978 |
| Chain | Residue |
| A | TYR654 |
| A | GLU656 |
| A | GLY657 |
| B | THR518 |
| B | GLU520 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B2978 |
| Chain | Residue |
| B | THR259 |
| B | ILE300 |
| B | ALA301 |
| B | ASP302 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B2979 |
| Chain | Residue |
| B | SER544 |
| B | TRP547 |
| B | ASN577 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B2980 |
| Chain | Residue |
| B | GLY465 |
| B | CYS466 |
| B | GLY467 |
| B | LYS468 |
| B | SER469 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B2981 |
| Chain | Residue |
| B | PRO415 |
| B | VAL416 |
| B | GLY417 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B2982 |
| Chain | Residue |
| A | THR518 |
| B | TYR654 |
| B | GLU656 |
| B | GLY657 |
| B | LYS659 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B2983 |
| Chain | Residue |
| A | GLU520 |
| B | VAL658 |
| B | LYS659 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B2984 |
| Chain | Residue |
| B | THR625 |
| B | HIS890 |
| B | ARG892 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ANP A2973 |
| Chain | Residue |
| A | ILE41 |
| A | HIS43 |
| A | ASP44 |
| A | SER82 |
| A | THR391 |
| A | ILE392 |
| A | HIS395 |
| A | GLU396 |
| A | ASN702 |
| A | GLU921 |
| A | ASN924 |
| A | HIS950 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ANP B2977 |
| Chain | Residue |
| B | ILE41 |
| B | HIS43 |
| B | ASP44 |
| B | SER82 |
| B | THR391 |
| B | HIS395 |
| B | GLU396 |
| B | ASN702 |
| B | GLU921 |
| B | ASN924 |
| B | HIS950 |
| B | SER951 |
| B | GLU953 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGWKMKLALARAV |
| Chain | Residue | Details |
| A | LEU543-VAL557 | |
| A | LEU896-THR910 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | PRO463 | |
| A | PRO701 | |
| B | PRO463 | |
| B | PRO701 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:9298649, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ASP2 | |
| B | ASP2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:22522802 |
| Chain | Residue | Details |
| A | ALA187 | |
| A | ALA196 | |
| A | ILE789 | |
| B | ALA187 | |
| B | ALA196 | |
| B | ILE789 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | ASN642 | |
| A | GLY974 | |
| B | ASN642 | |
| B | GLY974 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | PRO972 | |
| B | PRO972 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | ASP350 | |
| A | ALA636 | |
| B | ASP350 | |
| B | ALA636 |
