2IW3
Elongation Factor 3 in complex with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002182 | biological_process | cytoplasmic translational elongation |
| A | 0002184 | biological_process | cytoplasmic translational termination |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005840 | cellular_component | ribosome |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0006415 | biological_process | translational termination |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019843 | molecular_function | rRNA binding |
| A | 0022626 | cellular_component | cytosolic ribosome |
| A | 0043022 | molecular_function | ribosome binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002182 | biological_process | cytoplasmic translational elongation |
| B | 0002184 | biological_process | cytoplasmic translational termination |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005840 | cellular_component | ribosome |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0006415 | biological_process | translational termination |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0019843 | molecular_function | rRNA binding |
| B | 0022626 | cellular_component | cytosolic ribosome |
| B | 0043022 | molecular_function | ribosome binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1974 |
| Chain | Residue |
| A | SER544 |
| A | TRP547 |
| A | ASN577 |
| A | HOH2412 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1975 |
| Chain | Residue |
| A | LYS447 |
| A | GLN449 |
| A | LYS616 |
| A | ARG618 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1976 |
| Chain | Residue |
| A | ASN583 |
| A | ASN586 |
| B | ARG871 |
| A | VAL582 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1977 |
| Chain | Residue |
| A | GLU728 |
| A | ASN729 |
| A | ARG802 |
| A | LYS804 |
| A | TYR809 |
| A | HOH2291 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1978 |
| Chain | Residue |
| A | GLY465 |
| A | CYS466 |
| A | GLY467 |
| A | LYS468 |
| A | SER469 |
| A | HOH2413 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B1978 |
| Chain | Residue |
| B | THR259 |
| B | ALA301 |
| B | ASP302 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1979 |
| Chain | Residue |
| B | GLU728 |
| B | ASN729 |
| B | ARG802 |
| B | TYR809 |
| B | GLU859 |
| B | HOH2405 |
| B | HOH2551 |
| B | HOH2552 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B1980 |
| Chain | Residue |
| B | SER544 |
| B | TRP547 |
| B | ASN577 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1981 |
| Chain | Residue |
| B | LYS447 |
| B | GLN449 |
| B | LYS616 |
| B | ARG618 |
| B | HOH2273 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1982 |
| Chain | Residue |
| A | ARG871 |
| B | VAL582 |
| B | ASN583 |
| B | ASN586 |
| B | HOH2332 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1983 |
| Chain | Residue |
| B | HIS131 |
| B | ASN134 |
| B | LYS966 |
| B | HOH2553 |
| B | HOH2554 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B1984 |
| Chain | Residue |
| B | GLY465 |
| B | CYS466 |
| B | GLY467 |
| B | LYS468 |
| B | SER469 |
| B | HOH2284 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B1985 |
| Chain | Residue |
| B | SER544 |
| B | GLY545 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP A1973 |
| Chain | Residue |
| A | ILE41 |
| A | GLU42 |
| A | HIS43 |
| A | ASP44 |
| A | SER82 |
| A | PRO388 |
| A | THR391 |
| A | ILE392 |
| A | HIS395 |
| A | GLU396 |
| A | ASN702 |
| A | GLU921 |
| A | ASN924 |
| A | HIS950 |
| A | HOH2016 |
| A | HOH2411 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP B1977 |
| Chain | Residue |
| B | ILE41 |
| B | GLU42 |
| B | HIS43 |
| B | ASP44 |
| B | SER82 |
| B | THR391 |
| B | ILE392 |
| B | HIS395 |
| B | GLU396 |
| B | ASN702 |
| B | GLU921 |
| B | ASN924 |
| B | HIS950 |
| B | HOH2250 |
| B | HOH2393 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGWKMKLALARAV |
| Chain | Residue | Details |
| A | LEU543-VAL557 | |
| A | LEU896-THR910 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"HEAT 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16929303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IW3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IWH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16929303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"9298649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"22522802","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
