Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2IUB

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport
F	0000287	molecular_function	magnesium ion binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006824	biological_process	cobalt ion transport
F	0015087	molecular_function	cobalt ion transmembrane transporter activity
F	0015095	molecular_function	magnesium ion transmembrane transporter activity
F	0015693	biological_process	magnesium ion transport
F	0016020	cellular_component	membrane
F	0030001	biological_process	metal ion transport
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0046873	molecular_function	metal ion transmembrane transporter activity
F	0050897	molecular_function	cobalt ion binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
F	1903830	biological_process	magnesium ion transmembrane transport
G	0000287	molecular_function	magnesium ion binding
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006824	biological_process	cobalt ion transport
G	0015087	molecular_function	cobalt ion transmembrane transporter activity
G	0015095	molecular_function	magnesium ion transmembrane transporter activity
G	0015693	biological_process	magnesium ion transport
G	0016020	cellular_component	membrane
G	0030001	biological_process	metal ion transport
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0046873	molecular_function	metal ion transmembrane transporter activity
G	0050897	molecular_function	cobalt ion binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport
G	1903830	biological_process	magnesium ion transmembrane transport
H	0000287	molecular_function	magnesium ion binding
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006824	biological_process	cobalt ion transport
H	0015087	molecular_function	cobalt ion transmembrane transporter activity
H	0015095	molecular_function	magnesium ion transmembrane transporter activity
H	0015693	biological_process	magnesium ion transport
H	0016020	cellular_component	membrane
H	0030001	biological_process	metal ion transport
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0046873	molecular_function	metal ion transmembrane transporter activity
H	0050897	molecular_function	cobalt ion binding
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport
H	1903830	biological_process	magnesium ion transmembrane transport
I	0000287	molecular_function	magnesium ion binding
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006824	biological_process	cobalt ion transport
I	0015087	molecular_function	cobalt ion transmembrane transporter activity
I	0015095	molecular_function	magnesium ion transmembrane transporter activity
I	0015693	biological_process	magnesium ion transport
I	0016020	cellular_component	membrane
I	0030001	biological_process	metal ion transport
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0046873	molecular_function	metal ion transmembrane transporter activity
I	0050897	molecular_function	cobalt ion binding
I	0051260	biological_process	protein homooligomerization
I	0055085	biological_process	transmembrane transport
I	1903830	biological_process	magnesium ion transmembrane transport
J	0000287	molecular_function	magnesium ion binding
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006824	biological_process	cobalt ion transport
J	0015087	molecular_function	cobalt ion transmembrane transporter activity
J	0015095	molecular_function	magnesium ion transmembrane transporter activity
J	0015693	biological_process	magnesium ion transport
J	0016020	cellular_component	membrane
J	0030001	biological_process	metal ion transport
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0046873	molecular_function	metal ion transmembrane transporter activity
J	0050897	molecular_function	cobalt ion binding
J	0051260	biological_process	protein homooligomerization
J	0055085	biological_process	transmembrane transport
J	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A1351

Chain	Residue
A	ASP253
A	HIS257
A	HOH2002
B	ASP89

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A1352

Chain	Residue
A	ASP175
B	LEU12
B	HOH2001

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B1351

Chain	Residue
C	LEU12
B	ASP175
B	HOH2002

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C1350

Chain	Residue
B	ASP253
B	HOH2003
C	GLU88
C	ASP89

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C1351

Chain	Residue
C	ASP253
E	ASP89

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D1352

Chain	Residue
D	ASP277
E	ASP277

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D1353

Chain	Residue
D	ASP89
E	ASP253

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D1354

Chain	Residue
D	ASP179

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D1355

Chain	Residue
D	LEU12
D	PRO13
D	GLU88
E	HOH2001

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D1356

Chain	Residue
A	ASP89
D	ASP253

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F1350

Chain	Residue
F	PRO14
F	GLU88
I	HOH2001
I	HOH2002

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG F1352

Chain	Residue
I	LEU12

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG F1353

Chain	Residue
F	ASP89
F	HOH2001
I	ASP253

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G1352

Chain	Residue
G	ASP253
H	ASP89
H	HOH2001

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG G1353

Chain	Residue
F	ASP253
G	ASP89

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG G1354

Chain	Residue
F	ASP179

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG J1350

Chain	Residue
I	ASP89
J	ASP253

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG J1351

Chain	Residue
H	ASP253
J	ASP89

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG J1352

Chain	Residue
H	ASP175
H	HOH2002

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D1350

Chain	Residue
D	ILE160
D	ILE161
D	TYR168

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A1350

Chain	Residue
A	ILE160
A	ILE161
A	TYR168
B	PRO14

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B1350

Chain	Residue
B	ILE160
B	TYR168

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D1351

Chain	Residue
D	PRO13
E	ILE160
E	ILE161
E	TYR168

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G1350

Chain	Residue
G	ILE160
G	ILE161
G	TYR168

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F1351

Chain	Residue
I	PRO14
J	ILE160
J	TYR168

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G1351

Chain	Residue
H	ILE160
H	ILE161
H	TYR168

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	470
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Site: {"description":"Essential for ion permeation","evidences":[{"source":"PubMed","id":"23091000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Site: {"description":"Important for closing the ion permeation pathway in the closed state","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18276588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Site: {"description":"Threonine that confers selectivity for Co(2+) transport","evidences":[{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	200
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23112165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26871634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Motif: {"description":"Probable selectivity filter","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23781956","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)