2IRY
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with dGTP and Manganese.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1100 |
| Chain | Residue |
| A | ASP140 |
| A | ASP142 |
| A | DGT1102 |
| A | HOH1397 |
| A | HOH1412 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 1101 |
| Chain | Residue |
| B | HOH1394 |
| B | ASP140 |
| B | ASP142 |
| B | DGT1103 |
| B | HOH1387 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DGT A 1102 |
| Chain | Residue |
| A | PHE67 |
| A | LYS69 |
| A | ASP140 |
| A | ASP142 |
| A | SER175 |
| A | SER177 |
| A | LYS178 |
| A | GLY179 |
| A | HIS181 |
| A | GLN233 |
| A | THR239 |
| A | ARG247 |
| A | MN1100 |
| A | HOH1396 |
| A | HOH1397 |
| A | HOH1400 |
| A | HOH1401 |
| A | HOH1404 |
| A | HOH1412 |
| A | HOH1420 |
| A | HOH1426 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DGT B 1103 |
| Chain | Residue |
| B | ASP140 |
| B | ASP142 |
| B | SER175 |
| B | SER177 |
| B | LYS178 |
| B | GLY179 |
| B | HIS181 |
| B | ILE241 |
| B | ARG247 |
| B | MN1101 |
| B | HOH1387 |
| B | HOH1391 |
| B | HOH1394 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 62 |
| Details | DNA_BIND: Interaction with target DNA |
| Chain | Residue | Details |
| A | ASN16-LYS19 | |
| A | ASP230-LYS238 | |
| B | ASN16-LYS19 | |
| B | LYS29 | |
| B | ARG56-PRO58 | |
| B | PHE66-GLN70 | |
| B | SER74 | |
| B | HIS86-THR91 | |
| B | GLN107 | |
| B | ASP140 | |
| B | MET218-ARG223 | |
| A | LYS29 | |
| B | ASP230-LYS238 | |
| A | ARG56-PRO58 | |
| A | PHE66-GLN70 | |
| A | SER74 | |
| A | HIS86-THR91 | |
| A | GLN107 | |
| A | ASP140 | |
| A | MET218-ARG223 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17174332 |
| Chain | Residue | Details |
| A | LYS55 | |
| B | LYS55 | |
| B | HIS114 | |
| B | ASP140 | |
| B | ASP142 | |
| B | SER175 | |
| B | ASP230 | |
| B | GLN233 | |
| B | THR239 | |
| B | ARG247 | |
| A | HIS114 | |
| A | ASP140 | |
| A | ASP142 | |
| A | SER175 | |
| A | ASP230 | |
| A | GLN233 | |
| A | THR239 | |
| A | ARG247 |
