2IRY
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with dGTP and Manganese.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1100 |
| Chain | Residue |
| A | ASP140 |
| A | ASP142 |
| A | DGT1102 |
| A | HOH1397 |
| A | HOH1412 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 1101 |
| Chain | Residue |
| B | HOH1394 |
| B | ASP140 |
| B | ASP142 |
| B | DGT1103 |
| B | HOH1387 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DGT A 1102 |
| Chain | Residue |
| A | PHE67 |
| A | LYS69 |
| A | ASP140 |
| A | ASP142 |
| A | SER175 |
| A | SER177 |
| A | LYS178 |
| A | GLY179 |
| A | HIS181 |
| A | GLN233 |
| A | THR239 |
| A | ARG247 |
| A | MN1100 |
| A | HOH1396 |
| A | HOH1397 |
| A | HOH1400 |
| A | HOH1401 |
| A | HOH1404 |
| A | HOH1412 |
| A | HOH1420 |
| A | HOH1426 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DGT B 1103 |
| Chain | Residue |
| B | ASP140 |
| B | ASP142 |
| B | SER175 |
| B | SER177 |
| B | LYS178 |
| B | GLY179 |
| B | HIS181 |
| B | ILE241 |
| B | ARG247 |
| B | MN1101 |
| B | HOH1387 |
| B | HOH1391 |
| B | HOH1394 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 62 |
| Details | DNA binding: {"description":"Interaction with target DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 504 |
| Details | Region: {"description":"DNA repair polymerase domain (Pol); interacts with Ku"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17174332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
