2IRX
Crystal Structure of the Polymerase Domain from Mycobacterium tuberculosis Ligase D with GTP and Manganese.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 304 |
| Chain | Residue |
| A | ASP140 |
| A | ASP142 |
| A | GTP305 |
| A | HOH583 |
| A | HOH584 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GTP A 305 |
| Chain | Residue |
| A | ASP142 |
| A | SER175 |
| A | SER177 |
| A | LYS178 |
| A | GLY179 |
| A | HIS181 |
| A | GLN233 |
| A | THR239 |
| A | ARG247 |
| A | ARG249 |
| A | MN304 |
| A | HOH431 |
| A | HOH475 |
| A | HOH481 |
| A | HOH580 |
| A | HOH581 |
| A | HOH582 |
| A | HOH584 |
| A | HOH585 |
| A | HOH586 |
| A | HOH591 |
| A | HOH593 |
| A | HOH597 |
| A | HOH617 |
| A | LYS55 |
| A | PHE67 |
| A | HIS114 |
| A | ASP140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 31 |
| Details | DNA_BIND: Interaction with target DNA |
| Chain | Residue | Details |
| A | ASN16-LYS19 | |
| A | ASP230-LYS238 | |
| A | LYS29 | |
| A | ARG56-PRO58 | |
| A | PHE66-GLN70 | |
| A | SER74 | |
| A | HIS86-THR91 | |
| A | GLN107 | |
| A | ASP140 | |
| A | MET218-ARG223 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17174332 |
| Chain | Residue | Details |
| A | LYS55 | |
| A | HIS114 | |
| A | ASP140 | |
| A | ASP142 | |
| A | SER175 | |
| A | ASP230 | |
| A | GLN233 | |
| A | THR239 | |
| A | ARG247 |
