2IRV
Crystal structure of GlpG, a rhomboid intramembrane serine protease
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 5156 |
| Chain | Residue |
| B | HOH14 |
| B | TRP212 |
| B | ARG227 |
| B | GLY228 |
| B | ILE230 |
| B | LDA3847 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LDA B 3834 |
| Chain | Residue |
| B | ILE113 |
| B | LEU114 |
| A | LDA3842 |
| B | HOH69 |
| B | VAL106 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LDA B 3835 |
| Chain | Residue |
| A | VAL106 |
| B | TRP98 |
| B | ILE102 |
| B | LDA3836 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LDA B 3836 |
| Chain | Residue |
| A | LDA3845 |
| B | PRO95 |
| B | ILE102 |
| B | LDA3835 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LDA B 3837 |
| Chain | Residue |
| B | MET101 |
| B | PHE108 |
| B | LEU148 |
| B | LEU155 |
| B | LEU156 |
| B | TRP159 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LDA B 3838 |
| Chain | Residue |
| B | VAL96 |
| B | SER171 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LDA B 3839 |
| Chain | Residue |
| A | LDA3845 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LDA B 3840 |
| Chain | Residue |
| B | TRP241 |
| B | LMT3888 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LDA B 3841 |
| Chain | Residue |
| B | HOH61 |
| B | TRP241 |
| B | PHE242 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LDA A 3842 |
| Chain | Residue |
| A | GLY94 |
| A | PRO95 |
| A | TRP98 |
| A | VAL99 |
| B | LDA3834 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LDA B 3843 |
| Chain | Residue |
| B | LDA3844 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LDA B 3844 |
| Chain | Residue |
| B | LDA3843 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LDA A 3845 |
| Chain | Residue |
| B | LDA3836 |
| B | LDA3839 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LDA B 3847 |
| Chain | Residue |
| A | PHE242 |
| B | TRP212 |
| B | ILE230 |
| B | ILE231 |
| B | PO45156 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LDA A 3850 |
| Chain | Residue |
| A | TRP159 |
| A | TYR160 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMT B 3888 |
| Chain | Residue |
| B | HOH32 |
| B | HOH47 |
| B | HOH63 |
| B | LEU184 |
| B | PHE192 |
| B | SER193 |
| B | SER248 |
| B | MET249 |
| B | GLY252 |
| B | ALA256 |
| B | LDA3840 |
| site_id | BC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PGV B 5136 |
| Chain | Residue |
| B | HOH18 |
| B | HOH78 |
| B | HIS150 |
| B | PHE153 |
| B | ASN154 |
| B | TRP157 |
| B | SER201 |
| B | TYR205 |
| B | PHE232 |
| B | TRP236 |
| B | HIS254 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGV B 5138 |
| Chain | Residue |
| B | LEU229 |
| B | PHE232 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PGV B 5139 |
| Chain | Residue |
| B | TRP236 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 57 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"17051161","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17099694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17190827","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17277078","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"17051161","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17099694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17190827","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17277078","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
