2IPU

PFA1 Fab fragment complexed with Abeta 1-8 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0005576	cellular_component	extracellular region
K	0005886	cellular_component	plasma membrane
K	0019814	cellular_component	immunoglobulin complex
K	0046872	molecular_function	metal ion binding
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACM L 1219

Chain	Residue
H	VAL127
H	CYS128
L	PRO118
L	ASN209
L	GLU212
L	CYS213

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACM H 1138

Chain	Residue
K	ASP60
L	GLU212
L	CYS213
H	CYS128
H	GLY214
H	PRO215

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACM K 1219

Chain	Residue
G	VAL127
K	PRO118
K	ASN209
K	GLU212
K	CYS213

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL L 907

Chain	Residue
H	THR176
H	SER178
L	LEU159
L	SER175
L	SER176
L	THR177

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL L 909

Chain	Residue
L	PRO59
L	ARG61
L	PHE62
L	GLU81
L	ASP82

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL L 911

Chain	Residue
L	SER121
L	GLU122
L	THR125

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL K 901

Chain	Residue
K	LEU37
K	LYS45
K	PRO59
K	PHE62
K	GLU81
K	ASP82

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL K 903

Chain	Residue
H	ALA201
H	SER202
K	VAL51
K	GLY66
L	ARG187

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL K 905

Chain	Residue
G	ALA201
G	SER202
G	SER203
K	ARG187
L	GLY66

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by ACE","evidences":[{"source":"PubMed","id":"11604391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16154999","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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